SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kc1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P6K_B_MTLB871_0 (NITRIC-OXIDE SYNTHASE, BRAIN)	5kc1	AUTOPHAGY-RELATED PROTEIN 38 (Saccharomyces cerevisiae)	4 / 8	ARG C 137 ASN C 141 GLN C 139 PHE C 140	NO3 C 302 ( 3.4A) NA C 301 (-4.3A) None None	1.33A	1p6kB-5kc1C: undetectable	1p6kB-5kc1C: 19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RS6_B_MTLB871_0 (NITRIC-OXIDE SYNTHASE, BRAIN)	5kc1	AUTOPHAGY-RELATED PROTEIN 38 (Saccharomyces cerevisiae)	4 / 8	ARG C 137 ASN C 141 GLN C 139 PHE C 140	NO3 C 302 ( 3.4A) NA C 301 (-4.3A) None None	1.32A	1rs6B-5kc1C: undetectable	1rs6B-5kc1C: 19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RS7_B_MTLB871_0 (NITRIC-OXIDE SYNTHASE, BRAIN)	5kc1	AUTOPHAGY-RELATED PROTEIN 38 (Saccharomyces cerevisiae)	4 / 8	ARG C 137 ASN C 141 GLN C 139 PHE C 140	NO3 C 302 ( 3.4A) NA C 301 (-4.3A) None None	1.31A	1rs7B-5kc1C: undetectable	1rs7B-5kc1C: 19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZZQ_B_MTLB871_0 (NITRIC-OXIDE SYNTHASE, BRAIN)	5kc1	AUTOPHAGY-RELATED PROTEIN 38 (Saccharomyces cerevisiae)	4 / 8	ARG C 137 ASN C 141 GLN C 139 PHE C 140	NO3 C 302 ( 3.4A) NA C 301 (-4.3A) None None	1.31A	1zzqB-5kc1C: undetectable	1zzqB-5kc1C: 19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MK4_B_CHDB504_0 (FERROCHELATASE, MITOCHONDRIAL)	5kc1	AUTOPHAGY-RELATED PROTEIN 38 (Saccharomyces cerevisiae)	3 / 3	LEU C 130 ILE C 134 ARG C 137	None NO3 C 302 (-4.5A) NO3 C 302 ( 3.4A)	0.55A	4mk4B-5kc1C: undetectable	4mk4B-5kc1C: 21.67

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1P6K_B_MTLB871_0","NITRIC-OXIDE SYNTHASE, BRAIN","5kc1","AUTOPHAGY-RELATED PROTEIN 38","Saccharomyces cerevisiae",4,"ARG C 137;ASN C 141;GLN C 139;PHE C 140","NO3 C 302 ( 3.4A); NA C 301 (-4.3A);None;None","1.33A","1p6kB-5kc1C:undetectable","1p6kB-5kc1C:19.23"],["1RS6_B_MTLB871_0","NITRIC-OXIDE SYNTHASE, BRAIN","5kc1","AUTOPHAGY-RELATED PROTEIN 38","Saccharomyces cerevisiae",4,"ARG C 137;ASN C 141;GLN C 139;PHE C 140","NO3 C 302 ( 3.4A); NA C 301 (-4.3A);None;None","1.32A","1rs6B-5kc1C:undetectable","1rs6B-5kc1C:19.23"],["1RS7_B_MTLB871_0","NITRIC-OXIDE SYNTHASE, BRAIN","5kc1","AUTOPHAGY-RELATED PROTEIN 38","Saccharomyces cerevisiae",4,"ARG C 137;ASN C 141;GLN C 139;PHE C 140","NO3 C 302 ( 3.4A); NA C 301 (-4.3A);None;None","1.31A","1rs7B-5kc1C:undetectable","1rs7B-5kc1C:19.23"],["1ZZQ_B_MTLB871_0","NITRIC-OXIDE SYNTHASE, BRAIN","5kc1","AUTOPHAGY-RELATED PROTEIN 38","Saccharomyces cerevisiae",4,"ARG C 137;ASN C 141;GLN C 139;PHE C 140","NO3 C 302 ( 3.4A); NA C 301 (-4.3A);None;None","1.31A","1zzqB-5kc1C:undetectable","1zzqB-5kc1C:19.05"],["4MK4_B_CHDB504_0","FERROCHELATASE, MITOCHONDRIAL","5kc1","AUTOPHAGY-RELATED PROTEIN 38","Saccharomyces cerevisiae",3,"LEU C 130;ILE C 134;ARG C 137","None;NO3 C 302 (-4.5A);NO3 C 302 ( 3.4A)","0.55A","4mk4B-5kc1C:undetectable","4mk4B-5kc1C:21.67"]]