SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kc8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens) 		5 / 12 ILE A 204
ILE A 208
LEU A 227
ILE A 169
PHE A 212
 None
 1.07A 1bsxA-5kc8A:
undetectable		 1bsxA-5kc8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))		 5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens) 		5 / 12 ILE A 204
ILE A 208
LEU A 227
ILE A 169
PHE A 212
 None
 1.07A 1bsxB-5kc8A:
undetectable		 1bsxB-5kc8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens) 		5 / 12 ILE A 204
LEU A 232
PHE A 242
ILE A 169
LEU A 227
 None
 1.29A 1rh3A-5kc8A:
2.5		 1rh3A-5kc8A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens) 		3 / 3 ARG A 276
ARG A 275
ILE A 278
 None
 0.79A 1uobA-5kc8A:
undetectable		 1uobA-5kc8A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens) 		4 / 6 PHE A  44
VAL A 331
LEU A 334
SER A  25
 None
 0.86A 1wrlB-5kc8A:
undetectable		 1wrlB-5kc8A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens) 		5 / 12 ILE A 204
ILE A 208
LEU A 227
ILE A 169
PHE A 212
 None
 1.10A 1xzxX-5kc8A:
undetectable		 1xzxX-5kc8A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens) 		5 / 12 ILE A 261
ILE A 231
LEU A 185
ILE A 178
PHE A 168
 None
 1.15A 1xzxX-5kc8A:
undetectable		 1xzxX-5kc8A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens) 		4 / 5 ASN A 203
ALA A 237
LEU A 232
THR A 249
 None
 0.96A 3dl9A-5kc8A:
undetectable		 3dl9A-5kc8A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens) 		5 / 12 ILE A 204
ILE A 208
LEU A 227
ILE A 169
PHE A 212
 None
 1.08A 3gwsX-5kc8A:
undetectable		 3gwsX-5kc8A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens) 		5 / 10 SER A 354
LEU A  93
ILE A  90
SER A 352
GLY A  89
 None
 1.35A 3ijxB-5kc8A:
undetectable
3ijxD-5kc8A:
undetectable		 3ijxB-5kc8A:
19.63
3ijxD-5kc8A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens) 		5 / 10 ILE A  90
SER A 352
GLY A  89
SER A 354
LEU A  93
 None
 1.24A 3ik6B-5kc8A:
undetectable
3ik6E-5kc8A:
undetectable		 3ik6B-5kc8A:
19.63
3ik6E-5kc8A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens) 		5 / 10 SER A 354
LEU A  93
ILE A  90
SER A 352
GLY A  89
 None
 1.38A 3iluB-5kc8A:
undetectable
3iluE-5kc8A:
undetectable		 3iluB-5kc8A:
19.63
3iluE-5kc8A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens) 		5 / 11 ILE A  90
SER A 352
GLY A  89
SER A 354
LEU A  93
 None
 1.33A 3iluB-5kc8A:
undetectable
3iluE-5kc8A:
undetectable		 3iluB-5kc8A:
19.63
3iluE-5kc8A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens) 		5 / 12 ILE A 305
VAL A 331
PHE A  44
VAL A  43
ILE A 119
 None
 1.15A 3iw1A-5kc8A:
undetectable		 3iw1A-5kc8A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEK_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens) 		5 / 12 ARG A 300
GLY A 301
ASN A 302
ASN A 336
TYR A 328
 None
 1.15A 3mekA-5kc8A:
undetectable		 3mekA-5kc8A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWP_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)		 5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens) 		5 / 12 ARG A 300
GLY A 301
ASN A 302
ASN A 336
TYR A 328
 None
 1.14A 3qwpA-5kc8A:
undetectable		 3qwpA-5kc8A:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens) 		4 / 6 LEU A 185
VAL A 188
MET A 193
PHE A 168
 None
 1.04A 3soaA-5kc8A:
undetectable		 3soaA-5kc8A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens) 		5 / 9 LEU A 334
ALA A  47
ASP A  50
ILE A 305
LEU A 333
 None
 0.99A 3u7sA-5kc8A:
undetectable		 3u7sA-5kc8A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens) 		5 / 12 ILE A 259
ALA A 230
ILE A 181
LEU A 152
ILE A 156
 None
 1.07A 4pthA-5kc8A:
undetectable		 4pthA-5kc8A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCM_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens) 		5 / 12 ARG A 300
GLY A 301
ASN A 302
ASN A 336
TYR A 328
 None
 1.19A 5ccmA-5kc8A:
undetectable		 5ccmA-5kc8A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens) 		4 / 4 LEU A 144
MET A 369
ILE A 119
LEU A 334
 None
 1.37A 5nfpA-5kc8A:
undetectable		 5nfpA-5kc8A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens) 		4 / 6 ILE A 259
ILE A 178
LEU A 185
PHE A 184
 None
 0.99A 5vkqA-5kc8A:
undetectable
5vkqB-5kc8A:
undetectable		 5vkqA-5kc8A:
12.35
5vkqB-5kc8A:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens) 		4 / 6 ILE A 259
ILE A 178
LEU A 185
PHE A 184
 None
 0.98A 5vkqA-5kc8A:
undetectable
5vkqD-5kc8A:
undetectable		 5vkqA-5kc8A:
12.35
5vkqD-5kc8A:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXG_A_SAMA502_0
(SMYD3)		 5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens) 		5 / 12 ARG A 300
GLY A 301
ASN A 302
ASN A 336
TYR A 328
 None
 1.26A 5xxgA-5kc8A:
undetectable		 5xxgA-5kc8A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXJ_A_SAMA505_0
(SMYD3)		 5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens) 		5 / 12 ARG A 300
GLY A 301
ASN A 302
ASN A 336
TYR A 328
 None
 1.16A 5xxjA-5kc8A:
undetectable		 5xxjA-5kc8A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2
(Homo
sapiens) 		4 / 4 ILE A 327
LEU A 334
HIS A 116
ALA A  92
 None
 0.83A 6ck2C-5kc8A:
undetectable
6ck2D-5kc8A:
undetectable		 6ck2C-5kc8A:
8.20
6ck2D-5kc8A:
7.04