SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kc9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1
(Mus
musculus) 		4 / 7 THR A 106
SER A 104
TYR A 139
TRP A 359
 None
 1.37A 1eiiA-5kc9A:
0.9		 1eiiA-5kc9A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1
(Mus
musculus) 		4 / 8 SER A 319
ARG A 144
ASN A 320
ASP A  37
 None
 1.31A 1zzuA-5kc9A:
undetectable		 1zzuA-5kc9A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1
(Mus
musculus) 		4 / 8 ALA A 185
VAL A 157
THR A 158
LYS A 164
 PG4  A 523 ( 4.0A)
None
None
None
 1.20A 2kotB-5kc9A:
undetectable		 2kotB-5kc9A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1
(Mus
musculus) 		5 / 12 THR A 356
ASN A 350
VAL A  76
ALA A  79
ALA A 108
 None
 1.13A 3dl9B-5kc9A:
undetectable		 3dl9B-5kc9A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1
(Mus
musculus) 		3 / 3 GLU A 172
GLU A  31
ASN A  70
 None
 0.87A 3lp9B-5kc9A:
undetectable
3lp9D-5kc9A:
undetectable		 3lp9B-5kc9A:
19.65
3lp9D-5kc9A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1
(Mus
musculus) 		4 / 5 THR A  61
ILE A  24
LYS A  59
GLU A  58
 None
 1.29A 4ac9C-5kc9A:
5.9		 4ac9C-5kc9A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1
(Mus
musculus) 		4 / 5 THR A  61
ILE A  24
LYS A  59
GLU A  58
 None
 1.29A 4acaC-5kc9A:
5.8		 4acaC-5kc9A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1
(Mus
musculus) 		4 / 5 THR A  61
ILE A  24
LYS A  59
GLU A  58
 None
 1.26A 4acbC-5kc9A:
2.8		 4acbC-5kc9A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1
(Mus
musculus) 		4 / 7 LEU A 323
ASP A  37
SER A  93
GLU A 261
 None
 1.16A 4aq7A-5kc9A:
undetectable		 4aq7A-5kc9A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1
(Mus
musculus) 		4 / 6 PHE A 334
MET A 365
ILE A  24
VAL A  91
 None
 1.05A 4mk4B-5kc9A:
undetectable		 4mk4B-5kc9A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1
(Mus
musculus) 		4 / 6 TRP A 343
GLY A  86
ILE A  26
PHE A 334
 None
 1.03A 4qogA-5kc9A:
4.3
4qogB-5kc9A:
2.4		 4qogA-5kc9A:
19.91
4qogB-5kc9A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1
(Mus
musculus) 		3 / 3 PHE A  41
THR A 106
LEU A 330
 None
 0.57A 4qztA-5kc9A:
undetectable		 4qztA-5kc9A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1
(Mus
musculus) 		3 / 3 ILE A 262
MET A 315
ASP A 264
 None
None
EDO  A 503 ( 3.8A)
 0.78A 5h2uA-5kc9A:
undetectable		 5h2uA-5kc9A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1
(Mus
musculus) 		4 / 5 LEU A 316
TYR A 324
LEU A 313
TYR A 312
 None
None
EDO  A 511 (-4.6A)
None
 1.20A 5ki6A-5kc9A:
6.8		 5ki6A-5kc9A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1
(Mus
musculus) 		4 / 8 LEU A 270
LEU A 231
ILE A 318
GLN A 283
 BU1  A 520 (-4.1A)
None
None
None
 1.04A 5ljbA-5kc9A:
undetectable		 5ljbA-5kc9A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1
(Mus
musculus) 		5 / 12 VAL A 256
LEU A 154
PHE A 165
LEU A 190
VAL A 192
 None
None
None
None
PG4  A 523 (-3.7A)
 1.26A 6a93B-5kc9A:
undetectable		 6a93B-5kc9A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_A_STIA603_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1
(Mus
musculus) 		4 / 5 LEU A 321
TYR A 322
ILE A 396
GLY A 379
 CL  A 518 ( 4.9A)
None
None
None
 1.09A 6hd6A-5kc9A:
undetectable		 6hd6A-5kc9A:
11.20