SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kca'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_A_T3A1_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 12 ILE A 690
ILE A 694
LEU A 713
ILE A 655
PHE A 698
None
1.01A 1bsxA-5kcaA:
undetectable
1bsxA-5kcaA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BSX_B_T3B2_1
(PROTEIN (THYROID
HORMONE RECEPTOR
BETA))
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 12 ILE A 690
ILE A 694
LEU A 713
ILE A 655
PHE A 698
None
1.01A 1bsxB-5kcaA:
undetectable
1bsxB-5kcaA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 7 PHE A 258
ALA A 283
ILE A 226
ILE A 269
None
0.99A 1oniD-5kcaA:
undetectable
1oniF-5kcaA:
undetectable
1oniD-5kcaA:
11.13
1oniF-5kcaA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 7 PHE A 400
ALA A 425
ILE A 368
ILE A 411
None
0.99A 1oniD-5kcaA:
undetectable
1oniF-5kcaA:
undetectable
1oniD-5kcaA:
11.13
1oniF-5kcaA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 12 ILE A 747
ILE A 717
LEU A 671
ILE A 664
PHE A 654
None
1.14A 1xzxX-5kcaA:
undetectable
1xzxX-5kcaA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 8 LEU A 839
GLU A 215
HIS A 834
ALA A 837
None
0.96A 2bnnA-5kcaA:
2.2
2bnnB-5kcaA:
undetectable
2bnnA-5kcaA:
12.27
2bnnB-5kcaA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 12 ILE A 690
ILE A 694
LEU A 713
ILE A 655
PHE A 698
None
1.10A 2h79A-5kcaA:
undetectable
2h79A-5kcaA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 6 ARG A 715
PHE A 654
ILE A 717
PHE A 670
None
0.98A 2qeiA-5kcaA:
undetectable
2qeiA-5kcaA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 8 SER A 140
PHE A 142
VAL A 261
ASN A 213
None
1.01A 2wekA-5kcaA:
3.5
2wekA-5kcaA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 8 SER A 140
PHE A 142
VAL A 261
ASN A 213
None
1.03A 2wekB-5kcaA:
3.6
2wekB-5kcaA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YJA_B_ESTB1550_1
(ESTROGEN RECEPTOR)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 12 ALA A 564
LEU A 591
LEU A 594
ILE A 576
GLY A 516
None
1.20A 2yjaB-5kcaA:
undetectable
2yjaB-5kcaA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 12 ILE A 690
ILE A 694
LEU A 713
ILE A 655
PHE A 698
None
1.04A 3gwsX-5kcaA:
undetectable
3gwsX-5kcaA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 12 ILE A 791
VAL A 817
PHE A 530
VAL A 529
ILE A 605
None
1.17A 3iw1A-5kcaA:
undetectable
3iw1A-5kcaA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 12 LEU A 415
PHE A 398
ILE A 443
PHE A  64
SER A 154
None
1.22A 3ko0K-5kcaA:
undetectable
3ko0L-5kcaA:
undetectable
3ko0S-5kcaA:
undetectable
3ko0T-5kcaA:
undetectable
3ko0K-5kcaA:
7.91
3ko0L-5kcaA:
7.91
3ko0S-5kcaA:
7.91
3ko0T-5kcaA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 6 LEU A 415
PHE A 398
ILE A 443
PHE A  64
None
1.02A 3ko0S-5kcaA:
undetectable
3ko0S-5kcaA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEK_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 12 ARG A 786
GLY A 787
ASN A 788
ASN A 822
TYR A 814
None
1.18A 3mekA-5kcaA:
undetectable
3mekA-5kcaA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 12 THR A 184
ALA A 141
GLY A 440
HIS A 259
SER A 296
None
1.17A 3mg02-5kcaA:
undetectable
3mg0V-5kcaA:
undetectable
3mg02-5kcaA:
14.68
3mg0V-5kcaA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 6 GLY A 144
THR A 126
GLU A 151
ASP A 147
None
1.04A 3ps9A-5kcaA:
3.1
3ps9A-5kcaA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QWP_A_SAMA510_0
(SET AND MYND
DOMAIN-CONTAINING
PROTEIN 3)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 12 ARG A 786
GLY A 787
ASN A 788
ASN A 822
TYR A 814
None
1.19A 3qwpA-5kcaA:
undetectable
3qwpA-5kcaA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 6 LEU A 671
VAL A 674
MET A 679
PHE A 654
None
1.04A 3soaA-5kcaA:
undetectable
3soaA-5kcaA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 9 LEU A 820
ALA A 533
ASP A 536
ILE A 791
LEU A 819
None
0.99A 3u7sA-5kcaA:
undetectable
3u7sA-5kcaA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 12 ILE A 747
ILE A 717
LEU A 671
ILE A 664
PHE A 654
None
1.08A 3uvvA-5kcaA:
undetectable
3uvvA-5kcaA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 7 THR A 103
ASN A 134
LEU A 133
PHE A 185
None
1.38A 4awuA-5kcaA:
undetectable
4awuA-5kcaA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 7 THR A 245
ASN A 276
LEU A 275
PHE A 327
None
1.37A 4awuA-5kcaA:
undetectable
4awuA-5kcaA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 8 SER A 186
PHE A 185
THR A 103
PHE A 188
None
1.02A 4drjB-5kcaA:
undetectable
4drjB-5kcaA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 8 SER A 328
PHE A 327
THR A 245
PHE A 330
None
1.03A 4drjB-5kcaA:
undetectable
4drjB-5kcaA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 8 SER A 470
PHE A 469
THR A 387
PHE A 472
None
1.06A 4drjB-5kcaA:
undetectable
4drjB-5kcaA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 6 PHE A 114
ALA A 167
ALA A 106
PRO A 107
None
1.04A 4dtzB-5kcaA:
undetectable
4dtzB-5kcaA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 6 PHE A 256
ALA A 309
ALA A 248
PRO A 249
None
1.05A 4dtzB-5kcaA:
undetectable
4dtzB-5kcaA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 12 LEU A 455
ILE A 368
ILE A 411
ALA A 427
GLY A 440
None
1.10A 4enhA-5kcaA:
undetectable
4enhA-5kcaA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 7 ASP A 289
ASP A 287
GLU A 151
ASP A 431
None
1.19A 4fexB-5kcaA:
undetectable
4fexB-5kcaA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 8 ASP A 289
ASP A 287
GLU A 151
ASP A 431
None
1.17A 4gkhB-5kcaA:
undetectable
4gkhB-5kcaA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 8 ASP A 289
ASP A 287
GLU A 151
ASP A 431
None
1.20A 4gkiC-5kcaA:
undetectable
4gkiC-5kcaA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 5 ASN A 822
LEU A 819
SER A 865
ASN A 881
None
1.30A 4n09C-5kcaA:
undetectable
4n09C-5kcaA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 12 THR A 629
GLY A 877
ASN A 876
HIS A 602
SER A 581
None
1.22A 4pooB-5kcaA:
2.7
4pooB-5kcaA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 12 HIS A 259
SER A 296
THR A 184
ALA A 141
GLY A 440
None
1.19A 4qvnV-5kcaA:
undetectable
4qvnb-5kcaA:
undetectable
4qvnV-5kcaA:
14.24
4qvnb-5kcaA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 12 HIS A 401
SER A 438
THR A 326
ALA A 283
GLY A 156
None
1.16A 4qvnV-5kcaA:
undetectable
4qvnb-5kcaA:
undetectable
4qvnV-5kcaA:
14.24
4qvnb-5kcaA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 12 HIS A 259
SER A 296
THR A 184
ALA A 141
GLY A 440
None
1.18A 4qvnH-5kcaA:
undetectable
4qvnN-5kcaA:
undetectable
4qvnH-5kcaA:
14.24
4qvnN-5kcaA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 12 HIS A 401
SER A 438
THR A 326
ALA A 283
GLY A 156
None
1.15A 4qvnH-5kcaA:
undetectable
4qvnN-5kcaA:
undetectable
4qvnH-5kcaA:
14.24
4qvnN-5kcaA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 8 ASP A 145
GLU A 547
ILE A 512
TYR A 324
None
1.03A 4xjeA-5kcaA:
undetectable
4xjeA-5kcaA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
3 / 3 THR A 212
HIS A 599
LEU A 839
None
0.57A 5axdA-5kcaA:
4.1
5axdA-5kcaA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CCM_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 12 ARG A 786
GLY A 787
ASN A 788
ASN A 822
TYR A 814
None
1.22A 5ccmA-5kcaA:
undetectable
5ccmA-5kcaA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 8 ASP A 145
GLU A 547
ILE A 512
TYR A 324
None
0.96A 5cfsA-5kcaA:
undetectable
5cfsA-5kcaA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FQD_E_LVYE1438_1
(PROTEIN CEREBLON
CASEIN KINASE I
ISOFORM ALPHA)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 12 ASN A 115
HIS A 117
SER A 183
PHE A  86
ILE A 139
None
1.43A 5fqdE-5kcaA:
undetectable
5fqdF-5kcaA:
undetectable
5fqdE-5kcaA:
18.16
5fqdF-5kcaA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 4 LEU A 630
MET A 855
ILE A 605
LEU A 820
None
1.41A 5nfpA-5kcaA:
undetectable
5nfpA-5kcaA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 6 VAL A 261
TYR A 324
ASN A 213
ILE A 512
None
0.93A 5pbeA-5kcaA:
undetectable
5pbeA-5kcaA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UPD_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 11 ARG A 786
GLY A 787
ASN A 540
TYR A 814
LEU A 818
None
1.44A 5updA-5kcaA:
undetectable
5updA-5kcaA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V37_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 12 ARG A 786
GLY A 787
ASN A 788
ASN A 822
TYR A 814
None
1.43A 5v37A-5kcaA:
undetectable
5v37A-5kcaA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 6 ILE A 745
ILE A 664
LEU A 671
PHE A 670
None
1.00A 5vkqA-5kcaA:
undetectable
5vkqB-5kcaA:
undetectable
5vkqA-5kcaA:
19.13
5vkqB-5kcaA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 6 ILE A 745
ILE A 664
LEU A 671
PHE A 670
None
0.98A 5vkqA-5kcaA:
undetectable
5vkqD-5kcaA:
undetectable
5vkqA-5kcaA:
19.13
5vkqD-5kcaA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXG_A_SAMA502_0
(SMYD3)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 12 ARG A 786
GLY A 787
ASN A 788
ASN A 822
TYR A 814
None
1.30A 5xxgA-5kcaA:
undetectable
5xxgA-5kcaA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXJ_A_SAMA505_0
(SMYD3)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 12 ARG A 786
GLY A 787
ASN A 788
ASN A 822
TYR A 814
None
1.20A 5xxjA-5kcaA:
undetectable
5xxjA-5kcaA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CEN_A_SAMA1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 11 ARG A 786
GLY A 787
ASN A 540
TYR A 814
LEU A 818
None
1.39A 6cenA-5kcaA:
undetectable
6cenA-5kcaA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 4 ILE A 813
LEU A 820
HIS A 602
ALA A 578
None
0.86A 6ck2C-5kcaA:
undetectable
6ck2D-5kcaA:
undetectable
6ck2C-5kcaA:
2.58
6ck2D-5kcaA:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_ACTA405_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
4 / 6 PRO A 777
GLN A 782
ARG A 783
ILE A 780
None
1.46A 6ef6A-5kcaA:
undetectable
6ef6A-5kcaA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 12 HIS A 259
SER A 296
THR A 184
ALA A 141
GLY A 440
None
1.22A 6hwdV-5kcaA:
undetectable
6hwdb-5kcaA:
undetectable
6hwdV-5kcaA:
9.55
6hwdb-5kcaA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 12 HIS A 401
SER A 438
THR A 326
ALA A 283
GLY A 156
None
1.19A 6hwdV-5kcaA:
undetectable
6hwdb-5kcaA:
undetectable
6hwdV-5kcaA:
9.55
6hwdb-5kcaA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 12 HIS A 259
SER A 296
THR A 184
ALA A 141
GLY A 440
None
1.23A 6hwdH-5kcaA:
undetectable
6hwdN-5kcaA:
undetectable
6hwdH-5kcaA:
9.55
6hwdN-5kcaA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo
sapiens)
5 / 12 HIS A 401
SER A 438
THR A 326
ALA A 283
GLY A 156
None
1.20A 6hwdH-5kcaA:
undetectable
6hwdN-5kcaA:
undetectable
6hwdH-5kcaA:
9.55
6hwdN-5kcaA:
6.91