SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kci'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJ8_C_AZZC1211_1
(DEOXYNUCLEOSIDE
KINASE)		 5kci UNCHARACTERIZED
PROTEIN YPL067C
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 190
VAL A 169
LEU A 134
PHE A 133
ALA A  88
 None
None
None
None
ZN  A 201 ( 4.0A)
 1.46A 2jj8C-5kciA:
undetectable		 2jj8C-5kciA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 5kci UNCHARACTERIZED
PROTEIN YPL067C
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 143
PHE A 195
VAL A 187
THR A 186
LEU A 140
 None
 1.11A 2m9qA-5kciA:
undetectable		 2m9qA-5kciA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 5kci UNCHARACTERIZED
PROTEIN YPL067C
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 173
TYR A 178
HIS A 148
VAL A 149
 None
 1.29A 3lb3B-5kciA:
undetectable		 3lb3B-5kciA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5kci UNCHARACTERIZED
PROTEIN YPL067C
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 190
THR A 186
VAL A 106
ASP A  93
 None
 1.13A 4iaqA-5kciA:
undetectable		 4iaqA-5kciA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 5kci UNCHARACTERIZED
PROTEIN YPL067C
(Saccharomyces
cerevisiae) 		5 / 11 TYR A  96
HIS A 168
HIS A 166
TRP A 108
ASN A  92
 None
SO4  A 203 (-4.0A)
SO4  A 203 (-3.9A)
GOL  A 202 ( 4.3A)
None
 1.19A 4ir0A-5kciA:
undetectable
4ir0B-5kciA:
undetectable		 4ir0A-5kciA:
24.64
4ir0B-5kciA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 5kci UNCHARACTERIZED
PROTEIN YPL067C
(Saccharomyces
cerevisiae) 		5 / 8 ASN A 154
GLN A 159
SER A 160
HIS A 166
HIS A 168
 SO4  A 203 (-3.9A)
None
SO4  A 203 (-4.4A)
SO4  A 203 (-3.9A)
SO4  A 203 (-4.0A)
 0.87A 5km8A-5kciA:
3.6
5km8B-5kciA:
4.4		 5km8A-5kciA:
23.56
5km8B-5kciA:
23.56