SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kck'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5kck ANTHRANILATE
SYNTHASE COMPONENT I
(Streptococcus
pneumoniae) 		4 / 4 TYR A  73
LEU A  72
LEU A 395
HIS A  77
 None
 1.46A 2x7hB-5kckA:
undetectable		 2x7hB-5kckA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 5kck ANTHRANILATE
SYNTHASE COMPONENT I
(Streptococcus
pneumoniae) 		5 / 12 GLY A 115
PHE A  94
ILE A 250
TYR A 418
ILE A 411
 None
 1.08A 3pwwA-5kckA:
undetectable		 3pwwA-5kckA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5kck ANTHRANILATE
SYNTHASE COMPONENT I
(Streptococcus
pneumoniae) 		5 / 11 GLY A 386
ASP A  98
ALA A 389
GLU A 381
VAL A 365
 None
 1.24A 5hw4B-5kckA:
undetectable		 5hw4B-5kckA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 5kck ANTHRANILATE
SYNTHASE COMPONENT I
(Streptococcus
pneumoniae) 		5 / 12 GLY A 386
ASP A  98
ALA A 389
GLU A 381
VAL A 365
 None
 1.19A 5hw4C-5kckA:
undetectable		 5hw4C-5kckA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 5kck ANTHRANILATE
SYNTHASE COMPONENT I
(Streptococcus
pneumoniae) 		4 / 5 THR A 359
THR A 351
HIS A  77
LEU A 395
 None
 1.27A 5utuH-5kckA:
undetectable		 5utuH-5kckA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 5kck ANTHRANILATE
SYNTHASE COMPONENT I
(Streptococcus
pneumoniae) 		4 / 7 GLU A 383
GLY A 386
TYR A  97
TYR A 388
 None
 0.94A 5uxdA-5kckA:
undetectable		 5uxdA-5kckA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 5kck ANTHRANILATE
SYNTHASE COMPONENT I
(Streptococcus
pneumoniae) 		4 / 5 HIS A  81
SER A  83
GLY A  88
TYR A 127
 None
 1.25A 5yodD-5kckA:
undetectable		 5yodD-5kckA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 5kck ANTHRANILATE
SYNTHASE COMPONENT I
(Streptococcus
pneumoniae) 		4 / 5 HIS A  81
SER A  83
GLY A  88
TYR A 127
 None
 1.35A 5yodH-5kckA:
undetectable		 5yodH-5kckA:
20.27