SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kd0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 5kd0 AROMATIC
PRENYLTRANSFERASE
(Aspergillus
terreus) 		5 / 10 GLU A 337
ALA A 227
LEU A 231
ALA A 330
LEU A 265
 None
 1.33A 1ie4A-5kd0A:
undetectable
1ie4C-5kd0A:
undetectable		 1ie4A-5kd0A:
15.18
1ie4C-5kd0A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 5kd0 AROMATIC
PRENYLTRANSFERASE
(Aspergillus
terreus) 		4 / 8 MET A 274
PHE A 325
PHE A 345
ILE A 327
 None
 1.11A 1pnlA-5kd0A:
undetectable
1pnlB-5kd0A:
undetectable		 1pnlA-5kd0A:
18.64
1pnlB-5kd0A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5kd0 AROMATIC
PRENYLTRANSFERASE
(Aspergillus
terreus) 		4 / 7 LEU A 265
VAL A 255
GLY A 254
VAL A 152
 None
 0.66A 1t88A-5kd0A:
undetectable		 1t88A-5kd0A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5kd0 AROMATIC
PRENYLTRANSFERASE
(Aspergillus
terreus) 		4 / 8 LEU A 265
VAL A 255
GLY A 254
VAL A 152
 None
 0.70A 2a1oA-5kd0A:
undetectable		 2a1oA-5kd0A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 5kd0 AROMATIC
PRENYLTRANSFERASE
(Aspergillus
terreus) 		4 / 5 LEU A  42
LEU A 105
ILE A  92
ALA A  35
 None
 0.74A 2i2zA-5kd0A:
undetectable		 2i2zA-5kd0A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZQ9_A_CLSA11_1
(BETA-LACTAMASE
TOHO-1)		 5kd0 AROMATIC
PRENYLTRANSFERASE
(Aspergillus
terreus) 		4 / 4 GLU A 378
ARG A 374
ASN A 373
ASP A 370
 None
 1.17A 2zq9A-5kd0A:
undetectable		 2zq9A-5kd0A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5kd0 AROMATIC
PRENYLTRANSFERASE
(Aspergillus
terreus) 		3 / 3 ARG A 104
ASP A 182
ASP A 179
 GST  A 502 ( 3.4A)
None
GST  A 502 ( 4.4A)
 0.72A 3jayA-5kd0A:
undetectable		 3jayA-5kd0A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5kd0 AROMATIC
PRENYLTRANSFERASE
(Aspergillus
terreus) 		3 / 3 ARG A 104
ASP A 182
ASP A 179
 GST  A 502 ( 3.4A)
None
GST  A 502 ( 4.4A)
 0.88A 3jb2A-5kd0A:
undetectable		 3jb2A-5kd0A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 5kd0 AROMATIC
PRENYLTRANSFERASE
(Aspergillus
terreus) 		3 / 3 TYR A 402
GLY A 407
PRO A 408
 None
 0.68A 4qwpA-5kd0A:
undetectable		 4qwpA-5kd0A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 5kd0 AROMATIC
PRENYLTRANSFERASE
(Aspergillus
terreus) 		4 / 7 LEU A 359
LEU A 308
ASN A 351
ILE A 350
 None
 0.86A 4rmjA-5kd0A:
undetectable		 4rmjA-5kd0A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 5kd0 AROMATIC
PRENYLTRANSFERASE
(Aspergillus
terreus) 		5 / 9 LEU A 121
ASN A 172
ILE A 253
GLY A 251
ILE A 173
 None
 1.10A 5kqxB-5kd0A:
undetectable		 5kqxB-5kd0A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KXI_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 5kd0 AROMATIC
PRENYLTRANSFERASE
(Aspergillus
terreus) 		4 / 8 TYR A  59
THR A  37
CYH A 103
LEU A  42
 None
 1.48A 5kxiD-5kd0A:
undetectable
5kxiE-5kd0A:
undetectable		 5kxiD-5kd0A:
21.83
5kxiE-5kd0A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 5kd0 AROMATIC
PRENYLTRANSFERASE
(Aspergillus
terreus) 		4 / 8 GLN A 108
GLY A 106
ILE A  63
TRP A  30
 None
XBU  A 501 (-3.5A)
None
None
 0.91A 5vlmH-5kd0A:
undetectable		 5vlmH-5kd0A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 5kd0 AROMATIC
PRENYLTRANSFERASE
(Aspergillus
terreus) 		4 / 5 ASN A 411
VAL A 416
LEU A  90
SER A 177
 GST  A 502 (-3.7A)
None
None
XBU  A 501 (-2.7A)
 1.24A 6a7pA-5kd0A:
undetectable		 6a7pA-5kd0A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 5kd0 AROMATIC
PRENYLTRANSFERASE
(Aspergillus
terreus) 		4 / 8 TYR A  59
THR A  37
CYH A 103
LEU A  42
 None
 1.38A 6cnjD-5kd0A:
undetectable
6cnjE-5kd0A:
undetectable		 6cnjD-5kd0A:
12.83
6cnjE-5kd0A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA810_0
(UNCHARACTERIZED
PROTEIN)		 5kd0 AROMATIC
PRENYLTRANSFERASE
(Aspergillus
terreus) 		4 / 6 TYR A 414
TYR A 375
GLU A 378
LYS A 382
 None
 1.06A 6d8pA-5kd0A:
undetectable		 6d8pA-5kd0A:
20.42