SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kd5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLU A 813
ILE A 838
ALA A 619
TYR A 623
ARG A 815
 None
 1.13A 1ki7A-5kd5A:
undetectable		 1ki7A-5kd5A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 PHE A 449
TYR A 333
PRO A 357
 None
 1.16A 1mcnA-5kd5A:
undetectable
1mcnB-5kd5A:
undetectable
1mcnP-5kd5A:
undetectable		 1mcnA-5kd5A:
18.05
1mcnB-5kd5A:
18.05
1mcnP-5kd5A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 758
ASP A 641
ASN A 631
 None
 0.92A 1nbhA-5kd5A:
undetectable		 1nbhA-5kd5A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 758
ASP A 641
ASN A 631
 None
 0.89A 1nbhD-5kd5A:
undetectable		 1nbhD-5kd5A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 SER A 617
GLN A 627
ASN A 613
ASP A 641
 EDO  A 903 ( 4.3A)
None
EDO  A 903 (-4.1A)
None
 1.36A 1rs6A-5kd5A:
undetectable		 1rs6A-5kd5A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UHO_A_VDNA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 10 ALA A 751
PHE A 752
MET A 709
GLY A 711
PHE A 707
 None
 1.38A 1uhoA-5kd5A:
undetectable		 1uhoA-5kd5A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 GLU A 591
HIS A 574
HIS A 578
GLU A 575
 ZN  A 901 ( 2.3A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.2A)
EDO  A 904 (-2.4A)
 0.82A 1v7zA-5kd5A:
undetectable		 1v7zA-5kd5A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 GLU A 591
HIS A 574
HIS A 578
GLU A 575
 ZN  A 901 ( 2.3A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.2A)
EDO  A 904 (-2.4A)
 0.83A 1v7zB-5kd5A:
undetectable		 1v7zB-5kd5A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 GLU A 591
HIS A 574
HIS A 578
GLU A 575
 ZN  A 901 ( 2.3A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.2A)
EDO  A 904 (-2.4A)
 0.84A 1v7zC-5kd5A:
undetectable		 1v7zC-5kd5A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 GLU A 591
HIS A 574
HIS A 578
GLU A 575
 ZN  A 901 ( 2.3A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.2A)
EDO  A 904 (-2.4A)
 0.85A 1v7zD-5kd5A:
undetectable		 1v7zD-5kd5A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 GLU A 591
HIS A 574
HIS A 578
GLU A 575
 ZN  A 901 ( 2.3A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.2A)
EDO  A 904 (-2.4A)
 0.85A 1v7zE-5kd5A:
undetectable		 1v7zE-5kd5A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 GLU A 591
HIS A 574
HIS A 578
GLU A 575
 ZN  A 901 ( 2.3A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.2A)
EDO  A 904 (-2.4A)
 0.84A 1v7zF-5kd5A:
undetectable		 1v7zF-5kd5A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A 518
GLU A 478
TYR A 351
 None
 0.82A 1wsvA-5kd5A:
undetectable		 1wsvA-5kd5A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 SER A 617
GLN A 627
ASN A 613
ASP A 641
 EDO  A 903 ( 4.3A)
None
EDO  A 903 (-4.1A)
None
 1.34A 1zzqA-5kd5A:
undetectable		 1zzqA-5kd5A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 TYR A 656
CYH A 659
TYR A 661
ILE A 755
 None
 1.12A 2xz5A-5kd5A:
undetectable
2xz5B-5kd5A:
undetectable		 2xz5A-5kd5A:
17.56
2xz5B-5kd5A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 TYR A 656
CYH A 659
TYR A 661
ILE A 755
 None
 1.17A 2xz5B-5kd5A:
undetectable
2xz5E-5kd5A:
undetectable		 2xz5B-5kd5A:
17.56
2xz5E-5kd5A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 ILE A 755
TYR A 656
CYH A 659
TYR A 661
 None
 1.14A 2xz5A-5kd5A:
undetectable
2xz5C-5kd5A:
undetectable		 2xz5A-5kd5A:
17.56
2xz5C-5kd5A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 ILE A 755
TYR A 656
CYH A 659
TYR A 661
 None
 1.13A 2xz5C-5kd5A:
undetectable
2xz5D-5kd5A:
undetectable		 2xz5C-5kd5A:
17.56
2xz5D-5kd5A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 ILE A 755
TYR A 656
CYH A 659
TYR A 661
 None
 1.14A 2xz5D-5kd5A:
undetectable
2xz5E-5kd5A:
undetectable		 2xz5D-5kd5A:
17.56
2xz5E-5kd5A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 GLU A 591
HIS A 574
HIS A 578
GLU A 575
 ZN  A 901 ( 2.3A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.2A)
EDO  A 904 (-2.4A)
 0.83A 3a6jA-5kd5A:
undetectable		 3a6jA-5kd5A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 GLU A 591
HIS A 574
HIS A 578
GLU A 575
 ZN  A 901 ( 2.3A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.2A)
EDO  A 904 (-2.4A)
 0.80A 3a6jB-5kd5A:
undetectable		 3a6jB-5kd5A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 GLU A 591
HIS A 574
HIS A 578
GLU A 575
 ZN  A 901 ( 2.3A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.2A)
EDO  A 904 (-2.4A)
 0.80A 3a6jC-5kd5A:
undetectable		 3a6jC-5kd5A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 GLU A 591
HIS A 574
HIS A 578
GLU A 575
 ZN  A 901 ( 2.3A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.2A)
EDO  A 904 (-2.4A)
 0.83A 3a6jE-5kd5A:
undetectable		 3a6jE-5kd5A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 GLU A 591
HIS A 574
HIS A 578
GLU A 575
 ZN  A 901 ( 2.3A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.2A)
EDO  A 904 (-2.4A)
 0.81A 3a6jF-5kd5A:
undetectable		 3a6jF-5kd5A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ARG A 611
GLU A 756
ASP A 775
 None
 0.88A 3g2oA-5kd5A:
undetectable		 3g2oA-5kd5A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 HIS A 574
GLU A 575
HIS A 578
 ZN  A 901 ( 3.3A)
EDO  A 904 (-2.4A)
ZN  A 901 ( 3.2A)
 0.22A 3kecB-5kd5A:
undetectable		 3kecB-5kd5A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 ASP A 353
ASN A 424
SER A 398
 None
 0.98A 3lslA-5kd5A:
undetectable
3lslD-5kd5A:
undetectable		 3lslA-5kd5A:
19.43
3lslD-5kd5A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 SER A 398
ASP A 353
ASN A 424
 None
 0.95A 3lslA-5kd5A:
undetectable
3lslD-5kd5A:
undetectable		 3lslA-5kd5A:
19.43
3lslD-5kd5A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 GLN A 418
TYR A 483
GLN A 545
ILE A 532
 None
 0.94A 3peoG-5kd5A:
undetectable		 3peoG-5kd5A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 10 ALA A 628
PHE A 712
SER A 589
SER A 592
TYR A 728
 None
 1.10A 3qgtB-5kd5A:
undetectable		 3qgtB-5kd5A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 SER A 696
ALA A 699
LEU A 652
ILE A 584
PHE A 712
 None
 1.27A 3qt0A-5kd5A:
undetectable		 3qt0A-5kd5A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_C_BEZC264_0
(ECHA1_1)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 ALA A 811
GLU A 813
ALA A 751
MET A 709
 None
 1.21A 3r9tC-5kd5A:
undetectable		 3r9tC-5kd5A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 12 LYS A 844
LEU A 845
ALA A 794
ILE A 792
ILE A 803
 None
 1.08A 3ut5B-5kd5A:
undetectable		 3ut5B-5kd5A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 LYS A 460
GLU A 463
TRP A 324
 None
 1.48A 3v4tH-5kd5A:
undetectable		 3v4tH-5kd5A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 TYR A 768
ARG A 758
ASP A 567
GLU A 575
 None
None
None
EDO  A 904 (-2.4A)
 1.47A 4azvA-5kd5A:
undetectable		 4azvA-5kd5A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_2
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 PHE A 420
PHE A 530
TRP A 386
GLN A 383
 None
 1.43A 4b9zA-5kd5A:
0.0		 4b9zA-5kd5A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 HIS A 574
HIS A 578
TYR A 723
GLU A 591
 ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.2A)
None
ZN  A 901 ( 2.3A)
 0.94A 4pahA-5kd5A:
undetectable		 4pahA-5kd5A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB203_1
(CALMODULIN)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A 652
MET A 648
ALA A 698
MET A 673
 None
 0.82A 4rjdB-5kd5A:
undetectable		 4rjdB-5kd5A:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 8 PHE A 713
PHE A 691
TRP A 629
TYR A 728
 None
 1.49A 4v2zC-5kd5A:
undetectable		 4v2zC-5kd5A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		3 / 3 SER A 589
SER A 592
PHE A 712
 None
 0.93A 5mugA-5kd5A:
undetectable		 5mugA-5kd5A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 4 HIS A 574
HIS A 578
TYR A 723
GLU A 591
 ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.2A)
None
ZN  A 901 ( 2.3A)
 0.91A 5pahA-5kd5A:
undetectable		 5pahA-5kd5A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_B_SAMB201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 10 ILE A 435
ILE A 439
LEU A 404
HIS A 438
VAL A 370
 None
 1.09A 5twjB-5kd5A:
undetectable		 5twjB-5kd5A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 ASP A 505
ILE A 556
PHE A 484
ASN A 527
 None
 1.21A 6a93B-5kd5A:
undetectable		 6a93B-5kd5A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		5 / 9 THR A 358
GLY A 359
GLY A 448
TYR A 333
HIS A 455
 None
 1.37A 6gnfA-5kd5A:
undetectable		 6gnfA-5kd5A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 5 VAL A 362
PHE A 482
MET A 481
GLY A 477
 None
 1.33A 6hd4A-5kd5A:
undetectable		 6hd4A-5kd5A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 5kd5 METALLOPEPTIDASE
(Bacteroides
thetaiotaomicron) 		4 / 6 HIS A 574
HIS A 578
TYR A 723
GLU A 591
 ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.2A)
None
ZN  A 901 ( 2.3A)
 0.92A 6pahA-5kd5A:
undetectable		 6pahA-5kd5A:
19.19