SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kdi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 5kdi PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 8
(Homo
sapiens) 		5 / 12 LEU A 433
ALA A 456
GLY A 451
HIS A 445
PHE A 414
 6S8  A 601 ( 4.8A)
6S8  A 601 ( 3.8A)
None
6S8  A 601 (-3.9A)
6S8  A 601 (-4.6A)
 1.10A 1brpA-5kdiA:
undetectable		 1brpA-5kdiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 5kdi PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 8
(Homo
sapiens) 		4 / 8 ALA A 401
ALA A 404
ILE A 385
THR A 332
 None
 0.82A 3dtuC-5kdiA:
undetectable
3dtuD-5kdiA:
undetectable		 3dtuC-5kdiA:
undetectable
3dtuD-5kdiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 5kdi PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 8
(Homo
sapiens) 		4 / 6 THR A 420
ASN A 424
GLY A 425
ILE A 429
 None
 1.04A 3w9tF-5kdiA:
undetectable		 3w9tF-5kdiA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5kdi PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 8
(Homo
sapiens) 		4 / 6 LEU A 412
LYS A 416
LEU A 501
GLU A 498
 None
 1.03A 4f3tA-5kdiA:
undetectable		 4f3tA-5kdiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_A_3CJA607_1
(LACTOPEROXIDASE)		 5kdi PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 8
(Homo
sapiens) 		3 / 3 GLN A 443
HIS A 444
ARG A 410
 None
 0.89A 4qyqA-5kdiA:
undetectable		 4qyqA-5kdiA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYQ_B_3CJB607_1
(LACTOPEROXIDASE)		 5kdi PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 8
(Homo
sapiens) 		3 / 3 GLN A 443
HIS A 444
ARG A 410
 None
 0.86A 4qyqB-5kdiA:
undetectable		 4qyqB-5kdiA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5kdi PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 8
(Homo
sapiens) 		4 / 6 LEU A 412
LYS A 416
LEU A 501
GLU A 498
 None
 0.97A 4w5nA-5kdiA:
undetectable		 4w5nA-5kdiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 5kdi PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 8
(Homo
sapiens) 		4 / 6 GLU A 333
PHE A 379
THR A 374
TYR A 372
 None
 1.28A 5lrbA-5kdiA:
undetectable		 5lrbA-5kdiA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5kdi PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 8
(Homo
sapiens) 		4 / 7 LEU A 412
LYS A 416
LEU A 501
GLU A 498
 None
 0.98A 5t7bA-5kdiA:
undetectable		 5t7bA-5kdiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 5kdi PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY A MEMBER 8
(Homo
sapiens) 		5 / 12 ASP A 347
PHE A 466
ILE A 429
ALA A 436
THR A 440
 None
 1.27A 5vcgA-5kdiA:
0.5		 5vcgA-5kdiA:
12.87