SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kdr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 5kdr ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
ALPHA
(Staphylococcus
aureus) 		4 / 6 TYR A 133
GLY A 132
ASP A  91
GLY A 126
 None
 1.00A 1eswA-5kdrA:
undetectable		 1eswA-5kdrA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 5kdr ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
ALPHA
(Staphylococcus
aureus) 		5 / 12 PHE A 283
PHE A 151
THR A 156
TYR A 218
ALA A 207
 None
 1.40A 1fm4A-5kdrA:
undetectable		 1fm4A-5kdrA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 5kdr ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
ALPHA
(Staphylococcus
aureus) 		5 / 12 VAL A 106
ILE A 189
ILE A 261
SER A 281
LEU A 101
 None
 1.26A 1fm4A-5kdrA:
undetectable		 1fm4A-5kdrA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 5kdr ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
ALPHA
(Staphylococcus
aureus) 		5 / 12 GLU A 263
ILE A 193
ILE A 191
ALA A 278
ARG A  65
 None
 1.42A 1ki7B-5kdrA:
2.5		 1ki7B-5kdrA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 5kdr ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
ALPHA
(Staphylococcus
aureus) 		4 / 6 LEU A 202
GLY A 203
ASN A 177
ILE A 206
 None
 0.87A 1xf1B-5kdrA:
2.4		 1xf1B-5kdrA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 5kdr ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
ALPHA
(Staphylococcus
aureus) 		5 / 11 LEU A 287
ILE A 189
ALA A 285
LEU A 211
ASP A 259
 None
 1.12A 2qjuA-5kdrA:
undetectable		 2qjuA-5kdrA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5kdr ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
ALPHA
(Staphylococcus
aureus) 		5 / 11 ALA A 190
LEU A 202
ILE A 206
ILE A 309
THR A 152
 None
 1.04A 2w9sA-5kdrA:
undetectable		 2w9sA-5kdrA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_B_TOPB1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 5kdr ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
ALPHA
(Staphylococcus
aureus) 		5 / 11 ALA A 190
LEU A 202
ILE A 206
ILE A 309
THR A 152
 None
 1.04A 2w9sB-5kdrA:
undetectable		 2w9sB-5kdrA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 5kdr ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
ALPHA
(Staphylococcus
aureus) 		5 / 12 GLY A 197
GLY A 205
GLY A 200
PHE A 283
ILE A 191
 None
 1.07A 3eluA-5kdrA:
undetectable		 3eluA-5kdrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5kdr ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
ALPHA
(Staphylococcus
aureus) 		5 / 12 HIS A 129
TYR A 160
GLY A 114
GLY A 126
MET A 127
 None
 1.27A 3f8wB-5kdrA:
3.0		 3f8wB-5kdrA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_A_KANA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5kdr ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
ALPHA
(Staphylococcus
aureus) 		5 / 11 VAL A 188
THR A 152
GLN A 111
ALA A 201
ASN A 177
 None
 1.27A 3kp5A-5kdrA:
undetectable		 3kp5A-5kdrA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5kdr ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
ALPHA
(Staphylococcus
aureus) 		3 / 3 HIS A 249
SER A 262
GLU A 214
 None
 0.89A 3s8pA-5kdrA:
undetectable		 3s8pA-5kdrA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5kdr ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
ALPHA
(Staphylococcus
aureus) 		4 / 5 ALA A 241
ARG A  61
ALA A 226
GLU A 224
 None
 1.34A 5a06C-5kdrA:
3.6
5a06D-5kdrA:
3.5		 5a06C-5kdrA:
21.58
5a06D-5kdrA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5kdr ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
ALPHA
(Staphylococcus
aureus) 		4 / 6 ASP A  91
GLN A 111
GLU A 131
ALA A 164
 None
None
None
SO4  A 402 (-3.6A)
 1.20A 6djzB-5kdrA:
undetectable		 6djzB-5kdrA:
19.27