SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kds'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		5 / 11 ILE A 575
ALA A 616
LEU A 566
PRO A 547
ILE A 573
 None
 1.12A 1dg5A-5kdsA:
undetectable		 1dg5A-5kdsA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		4 / 8 GLU A 771
HIS A 756
HIS A 760
GLU A 757
 TLA  A1102 ( 2.5A)
ZN  A1101 (-3.3A)
ZN  A1101 ( 3.3A)
ZN  A1101 ( 4.3A)
 0.78A 1v7zA-5kdsA:
undetectable		 1v7zA-5kdsA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		4 / 8 GLU A 771
HIS A 756
HIS A 760
GLU A 757
 TLA  A1102 ( 2.5A)
ZN  A1101 (-3.3A)
ZN  A1101 ( 3.3A)
ZN  A1101 ( 4.3A)
 0.79A 1v7zB-5kdsA:
undetectable		 1v7zB-5kdsA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		4 / 8 GLU A 771
HIS A 756
HIS A 760
GLU A 757
 TLA  A1102 ( 2.5A)
ZN  A1101 (-3.3A)
ZN  A1101 ( 3.3A)
ZN  A1101 ( 4.3A)
 0.79A 1v7zC-5kdsA:
undetectable		 1v7zC-5kdsA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		4 / 8 GLU A 771
HIS A 756
HIS A 760
GLU A 757
 TLA  A1102 ( 2.5A)
ZN  A1101 (-3.3A)
ZN  A1101 ( 3.3A)
ZN  A1101 ( 4.3A)
 0.81A 1v7zD-5kdsA:
undetectable		 1v7zD-5kdsA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		4 / 8 GLU A 771
HIS A 756
HIS A 760
GLU A 757
 TLA  A1102 ( 2.5A)
ZN  A1101 (-3.3A)
ZN  A1101 ( 3.3A)
ZN  A1101 ( 4.3A)
 0.81A 1v7zE-5kdsA:
undetectable		 1v7zE-5kdsA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		4 / 8 GLU A 771
HIS A 756
HIS A 760
GLU A 757
 TLA  A1102 ( 2.5A)
ZN  A1101 (-3.3A)
ZN  A1101 ( 3.3A)
ZN  A1101 ( 4.3A)
 0.80A 1v7zF-5kdsA:
undetectable		 1v7zF-5kdsA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		3 / 3 GLY A 806
ARG A 883
TYR A 963
 None
 0.87A 2opxA-5kdsA:
undetectable		 2opxA-5kdsA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		4 / 7 TYR A 908
TYR A 802
PRO A 803
THR A 801
 None
 1.44A 2q6kA-5kdsA:
undetectable		 2q6kA-5kdsA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		4 / 8 GLU A 771
HIS A 756
HIS A 760
GLU A 757
 TLA  A1102 ( 2.5A)
ZN  A1101 (-3.3A)
ZN  A1101 ( 3.3A)
ZN  A1101 ( 4.3A)
 0.78A 3a6jA-5kdsA:
undetectable		 3a6jA-5kdsA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		4 / 7 GLU A 771
HIS A 756
HIS A 760
GLU A 757
 TLA  A1102 ( 2.5A)
ZN  A1101 (-3.3A)
ZN  A1101 ( 3.3A)
ZN  A1101 ( 4.3A)
 0.76A 3a6jB-5kdsA:
undetectable		 3a6jB-5kdsA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		4 / 8 GLU A 771
HIS A 756
HIS A 760
GLU A 757
 TLA  A1102 ( 2.5A)
ZN  A1101 (-3.3A)
ZN  A1101 ( 3.3A)
ZN  A1101 ( 4.3A)
 0.76A 3a6jC-5kdsA:
undetectable		 3a6jC-5kdsA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		4 / 8 GLU A 771
HIS A 756
HIS A 760
GLU A 757
 TLA  A1102 ( 2.5A)
ZN  A1101 (-3.3A)
ZN  A1101 ( 3.3A)
ZN  A1101 ( 4.3A)
 0.80A 3a6jE-5kdsA:
undetectable		 3a6jE-5kdsA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		4 / 8 GLU A 771
HIS A 756
HIS A 760
GLU A 757
 TLA  A1102 ( 2.5A)
ZN  A1101 (-3.3A)
ZN  A1101 ( 3.3A)
ZN  A1101 ( 4.3A)
 0.75A 3a6jF-5kdsA:
undetectable		 3a6jF-5kdsA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		4 / 6 ASP A 594
LEU A 550
LEU A 498
TRP A 521
 None
None
EDO  A1104 ( 4.1A)
None
 0.82A 3bj8C-5kdsA:
undetectable
3bj8D-5kdsA:
undetectable		 3bj8C-5kdsA:
14.72
3bj8D-5kdsA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		5 / 10 PHE A 781
VAL A 754
ASN A 749
ALA A 748
ILE A 692
 None
 1.28A 3t3qA-5kdsA:
undetectable		 3t3qA-5kdsA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		5 / 10 PHE A 781
VAL A 754
ASN A 749
ALA A 748
ILE A 692
 None
 1.31A 3t3qB-5kdsA:
undetectable		 3t3qB-5kdsA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_A_ACHA301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		4 / 7 TYR A 963
THR A 801
TYR A 908
TYR A 802
 None
 1.47A 3wipA-5kdsA:
undetectable
3wipB-5kdsA:
undetectable		 3wipA-5kdsA:
16.01
3wipB-5kdsA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_F_ACHF301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		4 / 7 TYR A 963
THR A 801
TYR A 908
TYR A 802
 None
 1.48A 3wipF-5kdsA:
undetectable
3wipG-5kdsA:
undetectable		 3wipF-5kdsA:
16.01
3wipG-5kdsA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		4 / 5 LEU A 722
HIS A 756
GLU A 757
HIS A 760
 None
ZN  A1101 (-3.3A)
ZN  A1101 ( 4.3A)
ZN  A1101 ( 3.3A)
 1.01A 4a7bB-5kdsA:
3.5		 4a7bB-5kdsA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		4 / 7 GLY A 525
THR A 524
ILE A 523
PHE A 664
 None
EDO  A1104 ( 4.3A)
None
None
 0.84A 4acaC-5kdsA:
undetectable		 4acaC-5kdsA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		4 / 8 ASP A 980
ASN A 937
ASP A 974
ILE A 938
 None
 0.91A 4k0bA-5kdsA:
undetectable		 4k0bA-5kdsA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		4 / 8 ASP A 980
ASN A 937
ASP A 974
ILE A 938
 None
 0.91A 4l7iA-5kdsA:
undetectable		 4l7iA-5kdsA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		5 / 12 ILE A 692
ALA A 693
MET A 696
GLY A 697
PHE A 701
 None
 1.06A 4r29D-5kdsA:
undetectable		 4r29D-5kdsA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		4 / 6 TYR A 907
GLU A 956
TYR A 990
LEU A 953
 None
 1.27A 4twdB-5kdsA:
undetectable
4twdC-5kdsA:
undetectable		 4twdB-5kdsA:
18.58
4twdC-5kdsA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		4 / 6 TYR A 907
GLU A 956
TYR A 990
LEU A 953
 None
 1.29A 4twdD-5kdsA:
undetectable
4twdE-5kdsA:
undetectable		 4twdD-5kdsA:
18.58
4twdE-5kdsA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		4 / 6 TYR A 907
GLU A 956
TYR A 990
LEU A 953
 None
 1.30A 4twdF-5kdsA:
undetectable
4twdG-5kdsA:
undetectable		 4twdF-5kdsA:
18.58
4twdG-5kdsA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		3 / 3 GLU A 845
ILE A 861
ALA A 869
 None
 0.54A 4wnwB-5kdsA:
undetectable		 4wnwB-5kdsA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJQ_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		5 / 12 THR A 598
SER A 506
MET A 696
ILE A 692
PHE A 762
 None
 1.29A 4zjqD-5kdsA:
undetectable		 4zjqD-5kdsA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		5 / 12 ASP A 871
ALA A 868
LYS A 514
PHE A 848
GLU A 850
 None
 1.25A 5hfjA-5kdsA:
undetectable		 5hfjA-5kdsA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		3 / 3 TYR A 691
TYR A 834
SER A 783
 None
 0.80A 5iktB-5kdsA:
undetectable		 5iktB-5kdsA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_1
(TUBULIN BETA-2B
CHAIN
TUBULIN ALPHA-1B
CHAIN)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		5 / 9 VAL A 964
PHE A 966
THR A 988
TYR A 985
LEU A 940
 None
 1.44A 5j2tB-5kdsA:
undetectable		 5j2tB-5kdsA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		5 / 10 MET A 696
ILE A 692
VAL A 515
PHE A 713
GLU A 509
 None
 1.42A 5tixB-5kdsA:
undetectable		 5tixB-5kdsA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 5kds F5/8 TYPE C DOMAIN
PROTEIN
(Clostridium
perfringens) 		5 / 12 PHE A 596
ALA A 561
GLY A 560
LEU A 549
ASP A 594
 None
 0.96A 5w7pA-5kdsA:
undetectable		 5w7pA-5kdsA:
24.09