SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kdx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 4 HIS A 154
LEU A 247
LEU A 165
LEU A  84
 None
 0.90A 1a4lD-5kdxA:
undetectable		 1a4lD-5kdxA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_A_DVAA6_0
(GRAMICIDIN A)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 670
VAL A 666
TRP A 685
 None
 0.78A 1grmA-5kdxA:
undetectable		 1grmA-5kdxA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GRM_B_DVAB6_0
(GRAMICIDIN A)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 670
VAL A 666
TRP A 685
 None
 0.78A 1grmB-5kdxA:
undetectable		 1grmB-5kdxA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 696
GLU A 697
HIS A 700
GLU A 716
TYR A 776
 ZN  A1005 ( 3.3A)
ZN  A1005 (-4.1A)
ZN  A1005 (-3.4A)
ZN  A1005 (-2.1A)
TNR  A1002 (-4.6A)
 0.47A 1j36A-5kdxA:
undetectable		 1j36A-5kdxA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 696
GLU A 697
HIS A 700
GLU A 716
TYR A 776
 ZN  A1005 ( 3.3A)
ZN  A1005 (-4.1A)
ZN  A1005 (-3.4A)
ZN  A1005 (-2.1A)
TNR  A1002 (-4.6A)
 0.47A 1j36B-5kdxA:
undetectable		 1j36B-5kdxA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 HIS A 696
GLU A 697
HIS A 700
GLU A 716
TYR A 776
 ZN  A1005 ( 3.3A)
ZN  A1005 (-4.1A)
ZN  A1005 (-3.4A)
ZN  A1005 (-2.1A)
TNR  A1002 (-4.6A)
 0.47A 1j37A-5kdxA:
2.5		 1j37A-5kdxA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 HIS A 696
GLU A 697
HIS A 700
GLU A 716
TYR A 776
 ZN  A1005 ( 3.3A)
ZN  A1005 (-4.1A)
ZN  A1005 (-3.4A)
ZN  A1005 (-2.1A)
TNR  A1002 (-4.6A)
 0.47A 1j37B-5kdxA:
2.5		 1j37B-5kdxA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_A_DVAA6_0
(GRAMICIDIN A)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 670
VAL A 666
TRP A 685
 None
 0.83A 1jnoA-5kdxA:
undetectable		 1jnoA-5kdxA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JNO_B_DVAB6_0
(GRAMICIDIN A)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 670
VAL A 666
TRP A 685
 None
 0.83A 1jnoB-5kdxA:
undetectable		 1jnoB-5kdxA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 670
VAL A 666
TRP A 685
 None
 0.88A 1jo3A-5kdxA:
undetectable		 1jo3A-5kdxA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 670
VAL A 666
TRP A 685
 None
 0.88A 1jo3B-5kdxA:
undetectable		 1jo3B-5kdxA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 670
VAL A 666
TRP A 685
 None
 0.77A 1jo4A-5kdxA:
undetectable		 1jo4A-5kdxA:
1.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 670
VAL A 666
TRP A 685
 None
 0.77A 1jo4B-5kdxA:
undetectable		 1jo4B-5kdxA:
1.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 347
PHE A 342
VAL A 404
 None
 0.77A 1kijB-5kdxA:
undetectable		 1kijB-5kdxA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 528
LEU A 442
VAL A 541
LEU A 526
ARG A 582
 None
 1.15A 1kt7A-5kdxA:
undetectable		 1kt7A-5kdxA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L4N_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 268
GLY A 134
LEU A 240
GLU A 131
GLY A 136
 None
 1.12A 1l4nA-5kdxA:
undetectable		 1l4nA-5kdxA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5K_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 268
GLY A 134
LEU A 240
GLU A 131
GLY A 136
 None
 1.14A 1l5kA-5kdxA:
undetectable		 1l5kA-5kdxA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 268
GLY A 134
LEU A 240
GLU A 131
GLY A 136
 None
 1.10A 1l5lA-5kdxA:
undetectable		 1l5lA-5kdxA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 268
GLY A 134
LEU A 240
GLU A 131
GLY A 136
 None
 1.10A 1l5mA-5kdxA:
undetectable		 1l5mA-5kdxA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_A_DVAA6_0
(GRAMICIDIN A)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 670
VAL A 666
TRP A 685
 None
 0.80A 1magA-5kdxA:
undetectable		 1magA-5kdxA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAG_B_DVAB6_0
(GRAMICIDIN A)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 670
VAL A 666
TRP A 685
 None
 0.80A 1magB-5kdxA:
undetectable		 1magB-5kdxA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 670
VAL A 666
TRP A 685
 None
 0.80A 1ng8A-5kdxA:
undetectable		 1ng8A-5kdxA:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 670
VAL A 666
TRP A 685
 None
 0.79A 1ng8B-5kdxA:
undetectable		 1ng8B-5kdxA:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 670
VAL A 666
TRP A 685
 None
 0.93A 1nrmA-5kdxA:
undetectable		 1nrmA-5kdxA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 670
VAL A 666
TRP A 685
 None
 0.93A 1nrmB-5kdxA:
undetectable		 1nrmB-5kdxA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_A_DVAA6_0
(GRAMICIDIN A)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 670
VAL A 666
TRP A 685
 None
 0.86A 1nruA-5kdxA:
undetectable		 1nruA-5kdxA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRU_B_DVAB6_0
(GRAMICIDIN A)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 670
VAL A 666
TRP A 685
 None
 0.86A 1nruB-5kdxA:
undetectable		 1nruB-5kdxA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 696
GLU A 697
HIS A 700
GLU A 716
TYR A 776
 ZN  A1005 ( 3.3A)
ZN  A1005 (-4.1A)
ZN  A1005 (-3.4A)
ZN  A1005 (-2.1A)
TNR  A1002 (-4.6A)
 0.50A 1o86A-5kdxA:
undetectable		 1o86A-5kdxA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 855
TRP A 789
THR A 868
TYR A 887
 None
 1.32A 1qvuA-5kdxA:
undetectable		 1qvuA-5kdxA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 829
TYR A 887
THR A 861
LEU A 860
 None
 0.96A 1v54A-5kdxA:
undetectable
1v54J-5kdxA:
undetectable		 1v54A-5kdxA:
20.04
1v54J-5kdxA:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_A_CRNA401_1
(CREATININE
AMIDOHYDROLASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 GLU A 716
HIS A 696
HIS A 700
GLU A 697
 ZN  A1005 (-2.1A)
ZN  A1005 ( 3.3A)
ZN  A1005 (-3.4A)
ZN  A1005 (-4.1A)
 0.93A 1v7zA-5kdxA:
undetectable		 1v7zA-5kdxA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_B_CRNB3401_1
(CREATININE
AMIDOHYDROLASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 GLU A 716
HIS A 696
HIS A 700
GLU A 697
 ZN  A1005 (-2.1A)
ZN  A1005 ( 3.3A)
ZN  A1005 (-3.4A)
ZN  A1005 (-4.1A)
 0.94A 1v7zB-5kdxA:
undetectable		 1v7zB-5kdxA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 GLU A 716
HIS A 696
HIS A 700
GLU A 697
 ZN  A1005 (-2.1A)
ZN  A1005 ( 3.3A)
ZN  A1005 (-3.4A)
ZN  A1005 (-4.1A)
 0.94A 1v7zC-5kdxA:
undetectable		 1v7zC-5kdxA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 GLU A 716
HIS A 696
HIS A 700
GLU A 697
 ZN  A1005 (-2.1A)
ZN  A1005 ( 3.3A)
ZN  A1005 (-3.4A)
ZN  A1005 (-4.1A)
 0.96A 1v7zD-5kdxA:
undetectable		 1v7zD-5kdxA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 GLU A 716
HIS A 696
HIS A 700
GLU A 697
 ZN  A1005 (-2.1A)
ZN  A1005 ( 3.3A)
ZN  A1005 (-3.4A)
ZN  A1005 (-4.1A)
 0.95A 1v7zE-5kdxA:
undetectable		 1v7zE-5kdxA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 GLU A 716
HIS A 696
HIS A 700
GLU A 697
 ZN  A1005 (-2.1A)
ZN  A1005 ( 3.3A)
ZN  A1005 (-3.4A)
ZN  A1005 (-4.1A)
 0.95A 1v7zF-5kdxA:
undetectable		 1v7zF-5kdxA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 349
LEU A  70
ALA A  67
ILE A 310
ALA A 379
 None
 1.17A 2bxpA-5kdxA:
1.2		 2bxpA-5kdxA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		6 / 12 GLN A 683
HIS A 696
GLU A 697
HIS A 700
GLU A 716
TYR A 776
 None
ZN  A1005 ( 3.3A)
ZN  A1005 (-4.1A)
ZN  A1005 (-3.4A)
ZN  A1005 (-2.1A)
TNR  A1002 (-4.6A)
 1.45A 2c6nA-5kdxA:
2.8		 2c6nA-5kdxA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 696
GLU A 697
HIS A 700
GLU A 716
TYR A 776
 ZN  A1005 ( 3.3A)
ZN  A1005 (-4.1A)
ZN  A1005 (-3.4A)
ZN  A1005 (-2.1A)
TNR  A1002 (-4.6A)
 0.56A 2c6nB-5kdxA:
undetectable		 2c6nB-5kdxA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 829
TYR A 887
THR A 861
LEU A 860
 None
 0.94A 2dyrA-5kdxA:
undetectable
2dyrJ-5kdxA:
undetectable		 2dyrA-5kdxA:
20.04
2dyrJ-5kdxA:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 829
TYR A 887
THR A 861
LEU A 860
 None
 0.96A 2dysA-5kdxA:
undetectable
2dysJ-5kdxA:
undetectable		 2dysA-5kdxA:
20.04
2dysJ-5kdxA:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 829
TYR A 887
THR A 861
LEU A 860
 None
 0.96A 2dysN-5kdxA:
undetectable
2dysW-5kdxA:
undetectable		 2dysN-5kdxA:
20.04
2dysW-5kdxA:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 829
TYR A 887
THR A 861
LEU A 860
 None
 0.97A 2eijA-5kdxA:
undetectable
2eijJ-5kdxA:
undetectable		 2eijA-5kdxA:
20.04
2eijJ-5kdxA:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 829
TYR A 887
THR A 861
LEU A 860
 None
 0.96A 2eilA-5kdxA:
undetectable
2eilJ-5kdxA:
undetectable		 2eilA-5kdxA:
20.04
2eilJ-5kdxA:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 6 TYR A 831
GLY A 839
TYR A 834
ASN A 840
 None
 1.08A 2g72A-5kdxA:
undetectable		 2g72A-5kdxA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 7 TYR A 497
GLN A 419
TYR A 522
ILE A 486
 None
 1.33A 2ph9A-5kdxA:
undetectable
2ph9B-5kdxA:
undetectable		 2ph9A-5kdxA:
12.54
2ph9B-5kdxA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 178
PRO A 201
ALA A 202
ALA A 161
LEU A 247
 None
 1.24A 2x2nB-5kdxA:
undetectable		 2x2nB-5kdxA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 HIS A 696
GLU A 697
HIS A 700
GLU A 716
TYR A 776
 ZN  A1005 ( 3.3A)
ZN  A1005 (-4.1A)
ZN  A1005 (-3.4A)
ZN  A1005 (-2.1A)
TNR  A1002 (-4.6A)
 0.46A 2x8zA-5kdxA:
3.3		 2x8zA-5kdxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 696
GLU A 697
HIS A 700
GLU A 716
TYR A 776
 ZN  A1005 ( 3.3A)
ZN  A1005 (-4.1A)
ZN  A1005 (-3.4A)
ZN  A1005 (-2.1A)
TNR  A1002 (-4.6A)
 0.49A 2x91A-5kdxA:
undetectable		 2x91A-5kdxA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBZ_A_VDXA501_1
(CYTOCHROME P450-SU1)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 THR A 174
VAL A 180
LEU A 244
ILE A 246
ALA A 161
 None
 1.21A 2zbzA-5kdxA:
undetectable		 2zbzA-5kdxA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_A_CRNA303_1
(CREATININE
AMIDOHYDROLASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 GLU A 716
HIS A 696
HIS A 700
GLU A 697
 ZN  A1005 (-2.1A)
ZN  A1005 ( 3.3A)
ZN  A1005 (-3.4A)
ZN  A1005 (-4.1A)
 0.94A 3a6jA-5kdxA:
undetectable		 3a6jA-5kdxA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_B_CRNB304_1
(CREATININE
AMIDOHYDROLASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 7 GLU A 716
HIS A 696
HIS A 700
GLU A 697
 ZN  A1005 (-2.1A)
ZN  A1005 ( 3.3A)
ZN  A1005 (-3.4A)
ZN  A1005 (-4.1A)
 0.92A 3a6jB-5kdxA:
undetectable		 3a6jB-5kdxA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_C_CRNC305_1
(CREATININE
AMIDOHYDROLASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 GLU A 716
HIS A 696
HIS A 700
GLU A 697
 ZN  A1005 (-2.1A)
ZN  A1005 ( 3.3A)
ZN  A1005 (-3.4A)
ZN  A1005 (-4.1A)
 0.93A 3a6jC-5kdxA:
undetectable		 3a6jC-5kdxA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_E_CRNE306_1
(CREATININE
AMIDOHYDROLASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 GLU A 716
HIS A 696
HIS A 700
GLU A 697
 ZN  A1005 (-2.1A)
ZN  A1005 ( 3.3A)
ZN  A1005 (-3.4A)
ZN  A1005 (-4.1A)
 0.95A 3a6jE-5kdxA:
undetectable		 3a6jE-5kdxA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A6J_F_CRNF307_1
(CREATININE
AMIDOHYDROLASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 GLU A 716
HIS A 696
HIS A 700
GLU A 697
 ZN  A1005 (-2.1A)
ZN  A1005 ( 3.3A)
ZN  A1005 (-3.4A)
ZN  A1005 (-4.1A)
 0.93A 3a6jF-5kdxA:
undetectable		 3a6jF-5kdxA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 829
TYR A 887
THR A 861
LEU A 860
 None
 0.98A 3abmA-5kdxA:
undetectable
3abmJ-5kdxA:
undetectable		 3abmA-5kdxA:
20.04
3abmJ-5kdxA:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 829
TYR A 887
THR A 861
LEU A 860
 None
 0.95A 3asnA-5kdxA:
undetectable
3asnJ-5kdxA:
undetectable		 3asnA-5kdxA:
20.04
3asnJ-5kdxA:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 829
TYR A 887
THR A 861
LEU A 860
 None
 0.95A 3asoA-5kdxA:
undetectable
3asoJ-5kdxA:
undetectable		 3asoA-5kdxA:
20.04
3asoJ-5kdxA:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 297
ILE A 118
PRO A 115
SER A 127
THR A 113
 None
 1.30A 3bjwB-5kdxA:
undetectable		 3bjwB-5kdxA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 297
ILE A 118
PRO A 115
SER A 127
THR A 113
 None
 1.31A 3bjwH-5kdxA:
undetectable		 3bjwH-5kdxA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 LEU A 526
ALA A 547
ALA A 546
VAL A 479
GLN A 430
 None
 1.18A 3bszE-5kdxA:
undetectable		 3bszE-5kdxA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 ARG A 863
TYR A 792
ASP A 912
GLN A 915
 None
 1.28A 3dh0A-5kdxA:
undetectable		 3dh0A-5kdxA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 10 VAL A 222
PHE A 248
LEU A 158
VAL A 162
LEU A 144
 None
 0.91A 3gwxA-5kdxA:
undetectable		 3gwxA-5kdxA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		3 / 3 HIS A 696
GLU A 697
HIS A 700
 ZN  A1005 ( 3.3A)
ZN  A1005 (-4.1A)
ZN  A1005 (-3.4A)
 0.20A 3kecB-5kdxA:
undetectable		 3kecB-5kdxA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		3 / 3 ASP A 649
ASN A 825
SER A 652
 None
 0.87A 3lsfB-5kdxA:
undetectable
3lsfE-5kdxA:
undetectable		 3lsfB-5kdxA:
14.07
3lsfE-5kdxA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_D_AC2D601_1
(DEOXYCYTIDINE KINASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 GLU A 587
GLN A 549
ARG A 582
PHE A 551
 None
 1.17A 3mjrD-5kdxA:
undetectable		 3mjrD-5kdxA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 GLN A 419
ASP A 380
LEU A  60
VAL A  66
ALA A  67
 None
 1.26A 3n23C-5kdxA:
undetectable		 3n23C-5kdxA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 162
LEU A 247
GLY A 198
ALA A 197
LEU A 194
 None
 1.09A 3nt1A-5kdxA:
undetectable		 3nt1A-5kdxA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 162
LEU A 247
GLY A 198
ALA A 197
LEU A 194
 None
 1.07A 3nt1B-5kdxA:
undetectable		 3nt1B-5kdxA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 130
LEU A 128
LEU A 165
GLY A 243
LEU A 240
 None
 0.93A 3olsA-5kdxA:
undetectable		 3olsA-5kdxA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 143
VAL A 162
LEU A 247
GLY A 198
ALA A 197
 None
 1.31A 3pghA-5kdxA:
undetectable		 3pghA-5kdxA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 162
LEU A 247
GLY A 198
ALA A 197
LEU A 194
 None
 1.00A 3pghA-5kdxA:
undetectable		 3pghA-5kdxA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_D_FLPD701_1
(CYCLOOXYGENASE-2)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 162
LEU A 247
GLY A 198
ALA A 197
LEU A 194
 None
 1.00A 3pghD-5kdxA:
undetectable		 3pghD-5kdxA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 465
ALA A 460
LEU A 481
ILE A 455
GLY A 456
 None
None
EDO  A1009 ( 3.5A)
None
None
 1.15A 3q95A-5kdxA:
undetectable		 3q95A-5kdxA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_B_ESLB700_1
(ESTROGEN RECEPTOR)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 130
LEU A 128
LEU A 165
GLY A 243
LEU A 240
 None
 0.92A 3q95B-5kdxA:
undetectable		 3q95B-5kdxA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 451
THR A 661
GLY A 660
PRO A 659
PRO A 447
 None
 1.41A 3t8nD-5kdxA:
undetectable
3t8nF-5kdxA:
undetectable		 3t8nD-5kdxA:
8.76
3t8nF-5kdxA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T8N_D_EDTD135_0
(STEROID
DELTA-ISOMERASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 THR A 661
GLY A 660
PRO A 659
PRO A 447
GLY A 451
 None
 1.42A 3t8nD-5kdxA:
undetectable
3t8nF-5kdxA:
undetectable		 3t8nD-5kdxA:
8.76
3t8nF-5kdxA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_D_BEZD1_0
(HEME-BINDING PROTEIN
HUTZ)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 6 GLN A 703
PHE A 722
PRO A 723
LEU A 698
 None
EDO  A1008 (-4.7A)
None
None
 1.38A 3tgvD-5kdxA:
undetectable		 3tgvD-5kdxA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		3 / 3 PHE A 452
LYS A 504
SER A 505
 None
EDO  A1011 (-4.0A)
EDO  A1011 ( 3.6A)
 1.00A 3tyeB-5kdxA:
undetectable		 3tyeB-5kdxA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_1
(METHYLTRANSFERASE
WBDD)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 863
ASP A 912
GLN A 915
 None
 0.73A 4azsA-5kdxA:
undetectable		 4azsA-5kdxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 11 HIS A 696
GLU A 697
HIS A 700
GLU A 716
TYR A 776
 ZN  A1005 ( 3.3A)
ZN  A1005 (-4.1A)
ZN  A1005 (-3.4A)
ZN  A1005 (-2.1A)
TNR  A1002 (-4.6A)
 0.41A 4c2pA-5kdxA:
undetectable		 4c2pA-5kdxA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 377
LEU A 374
SER A 371
THR A 369
 None
 1.24A 4d7bB-5kdxA:
undetectable		 4d7bB-5kdxA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 10 VAL A 249
TYR A 139
VAL A 185
LEU A 165
LEU A 220
 None
 1.34A 4jtqA-5kdxA:
undetectable		 4jtqA-5kdxA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 9 GLY A 268
GLY A 134
LEU A 240
GLU A 131
GLY A 136
 None
 1.10A 4kqiA-5kdxA:
undetectable		 4kqiA-5kdxA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 529
LEU A 481
GLY A 480
ILE A 467
LEU A 510
 EDO  A1016 ( 4.9A)
EDO  A1009 ( 3.5A)
EDO  A1011 (-3.2A)
None
None
 1.19A 4o5fA-5kdxA:
undetectable
4o5fB-5kdxA:
undetectable		 4o5fA-5kdxA:
17.04
4o5fB-5kdxA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 510
VAL A 529
LEU A 481
GLY A 480
ILE A 467
 None
EDO  A1016 ( 4.9A)
EDO  A1009 ( 3.5A)
EDO  A1011 (-3.2A)
None
 1.18A 4o5fA-5kdxA:
undetectable
4o5fB-5kdxA:
undetectable		 4o5fA-5kdxA:
17.04
4o5fB-5kdxA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 10 VAL A 162
LEU A 247
GLY A 198
ALA A 197
LEU A 194
 None
 1.06A 4ph9A-5kdxA:
0.6		 4ph9A-5kdxA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 10 VAL A 162
LEU A 247
GLY A 198
ALA A 197
LEU A 194
 None
 1.04A 4ph9B-5kdxA:
0.6		 4ph9B-5kdxA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 130
LEU A 128
LEU A 165
GLY A 243
LEU A 240
 None
 0.93A 4pxmA-5kdxA:
undetectable		 4pxmA-5kdxA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 10 GLU A 580
VAL A 588
ILE A 664
TYR A 681
PHE A 618
 None
None
None
None
EDO  A1008 (-4.4A)
 1.41A 4qt2A-5kdxA:
undetectable		 4qt2A-5kdxA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 ALA A 478
TYR A 411
SER A 505
LEU A 481
LEU A 465
 EDO  A1016 (-3.5A)
EDO  A1009 (-4.3A)
EDO  A1011 ( 3.6A)
EDO  A1009 ( 3.5A)
None
 1.47A 4qztC-5kdxA:
undetectable		 4qztC-5kdxA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 HIS A 696
GLU A 697
HIS A 700
GLU A 716
TYR A 776
 ZN  A1005 ( 3.3A)
ZN  A1005 (-4.1A)
ZN  A1005 (-3.4A)
ZN  A1005 (-2.1A)
TNR  A1002 (-4.6A)
 0.87A 4r7lA-5kdxA:
5.9		 4r7lA-5kdxA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 9 VAL A 162
LEU A 247
GLY A 198
ALA A 197
LEU A 194
 None
 1.02A 4rs0A-5kdxA:
undetectable		 4rs0A-5kdxA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 588
LEU A 579
ILE A 664
GLY A 597
LEU A 571
 None
 1.01A 4y8wC-5kdxA:
undetectable		 4y8wC-5kdxA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 529
LEU A 481
GLY A 480
ILE A 467
LEU A 510
 EDO  A1016 ( 4.9A)
EDO  A1009 ( 3.5A)
EDO  A1011 (-3.2A)
None
None
 1.18A 5b8hA-5kdxA:
undetectable
5b8hB-5kdxA:
undetectable		 5b8hA-5kdxA:
17.89
5b8hB-5kdxA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 510
VAL A 529
LEU A 481
GLY A 480
ILE A 467
 None
EDO  A1016 ( 4.9A)
EDO  A1009 ( 3.5A)
EDO  A1011 (-3.2A)
None
 1.13A 5b8hA-5kdxA:
undetectable
5b8hB-5kdxA:
undetectable		 5b8hA-5kdxA:
17.89
5b8hB-5kdxA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 5 PRO A 838
LEU A 860
TYR A 811
PHE A 628
 None
 1.43A 5igjA-5kdxA:
undetectable		 5igjA-5kdxA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 SER A 505
LEU A 481
GLY A 480
VAL A 529
LEU A 518
 EDO  A1011 ( 3.6A)
EDO  A1009 ( 3.5A)
EDO  A1011 (-3.2A)
EDO  A1016 ( 4.9A)
None
 1.30A 5jo9A-5kdxA:
undetectable		 5jo9A-5kdxA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 162
LEU A 247
GLY A 198
ALA A 197
LEU A 194
 None
 1.10A 5jvzA-5kdxA:
0.7		 5jvzA-5kdxA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_B_FLPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 162
LEU A 247
GLY A 198
ALA A 197
LEU A 194
 None
 1.06A 5jvzB-5kdxA:
undetectable		 5jvzB-5kdxA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 162
LEU A 247
GLY A 198
ALA A 197
LEU A 194
 None
 1.07A 5jw1A-5kdxA:
undetectable		 5jw1A-5kdxA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 667
GLN A 428
PRO A 500
ARG A 499
LEU A 422
 EDO  A1007 (-3.4A)
None
None
None
None
 1.31A 5m50B-5kdxA:
undetectable		 5m50B-5kdxA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 667
PRO A 500
ARG A 499
GLY A 423
LEU A 422
 EDO  A1007 (-3.4A)
None
None
None
None
 1.37A 5m50B-5kdxA:
undetectable		 5m50B-5kdxA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 673
ARG A 485
GLN A 484
ASP A 682
 None
None
EDO  A1007 (-4.4A)
EDO  A1007 (-2.5A)
 1.06A 5vlmB-5kdxA:
undetectable		 5vlmB-5kdxA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 7 GLN A 720
GLY A 699
GLN A 814
ASP A 621
 TNR  A1002 (-3.1A)
None
None
EDO  A1008 (-3.6A)
 1.09A 5vlmE-5kdxA:
1.8		 5vlmE-5kdxA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 440
GLY A 437
VAL A 479
LEU A 481
SER A 548
 None
None
None
EDO  A1009 ( 3.5A)
None
 1.17A 5vooA-5kdxA:
undetectable		 5vooA-5kdxA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 440
GLY A 437
VAL A 479
LEU A 481
SER A 548
 None
None
None
EDO  A1009 ( 3.5A)
None
 1.18A 5vooC-5kdxA:
undetectable		 5vooC-5kdxA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 GLU A 271
GLY A 140
VAL A 236
GLY A 260
ASN A 225
 None
 1.16A 5vopB-5kdxA:
undetectable		 5vopB-5kdxA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		3 / 3 GLY A 368
ASN A 109
ARG A 237
 PO4  A1004 (-3.3A)
None
None
 0.72A 5w7bD-5kdxA:
undetectable		 5w7bD-5kdxA:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 829
TYR A 887
THR A 861
LEU A 860
 None
 0.97A 5x1fA-5kdxA:
undetectable
5x1fJ-5kdxA:
undetectable		 5x1fA-5kdxA:
20.04
5x1fJ-5kdxA:
6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 10 TYR A 749
ALA A 748
LEU A 871
VAL A 765
GLY A 755
 None
 1.32A 5zbdA-5kdxA:
undetectable		 5zbdA-5kdxA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 158
VAL A 236
LEU A 209
LEU A 144
PHE A 248
 None
 1.14A 6a7pA-5kdxA:
undetectable		 6a7pA-5kdxA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		3 / 3 ARG A 468
LYS A 542
ARG A 582
 None
 1.29A 6c06D-5kdxA:
0.7		 6c06D-5kdxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_B_REAB601_1
(RETINOIC ACID
RECEPTOR)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 10 ARG A 123
VAL A 124
LEU A 125
LEU A  85
GLY A 298
 None
 1.15A 6eu9B-5kdxA:
undetectable		 6eu9B-5kdxA:
6.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 10 VAL A 162
ALA A 161
LEU A 194
LEU A 144
LEU A 220
 None
 0.95A 6f5uA-5kdxA:
undetectable
6f5uB-5kdxA:
undetectable		 6f5uA-5kdxA:
6.87
6f5uB-5kdxA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 10 VAL A 162
ALA A 161
LEU A 194
LEU A 144
LEU A 220
 None
 1.04A 6f6nA-5kdxA:
undetectable
6f6nB-5kdxA:
undetectable		 6f6nA-5kdxA:
6.87
6f6nB-5kdxA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 380
ILE A 408
TRP A 375
ARG A 383
 None
 1.17A 6hisA-5kdxA:
undetectable
6hisB-5kdxA:
undetectable		 6hisA-5kdxA:
7.00
6hisB-5kdxA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 864
ARG A 866
TRP A 859
TYR A 831
 None
 1.07A 6hisA-5kdxA:
undetectable
6hisB-5kdxA:
undetectable		 6hisA-5kdxA:
7.00
6hisB-5kdxA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 380
ILE A 408
TRP A 375
ARG A 383
 None
 1.17A 6hisB-5kdxA:
undetectable
6hisC-5kdxA:
undetectable		 6hisB-5kdxA:
7.00
6hisC-5kdxA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 864
ARG A 866
TRP A 859
TYR A 831
 None
 1.07A 6hisB-5kdxA:
undetectable
6hisC-5kdxA:
undetectable		 6hisB-5kdxA:
7.00
6hisC-5kdxA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 380
ILE A 408
TRP A 375
ARG A 383
 None
 1.17A 6hisC-5kdxA:
undetectable
6hisD-5kdxA:
undetectable		 6hisC-5kdxA:
7.00
6hisD-5kdxA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 864
ARG A 866
TRP A 859
TYR A 831
 None
 1.08A 6hisC-5kdxA:
undetectable
6hisD-5kdxA:
undetectable		 6hisC-5kdxA:
7.00
6hisD-5kdxA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 380
ILE A 408
TRP A 375
ARG A 383
 None
 1.18A 6hisD-5kdxA:
undetectable
6hisE-5kdxA:
undetectable		 6hisD-5kdxA:
7.00
6hisE-5kdxA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 864
ARG A 866
TRP A 859
TYR A 831
 None
 1.07A 6hisD-5kdxA:
undetectable
6hisE-5kdxA:
undetectable		 6hisD-5kdxA:
7.00
6hisE-5kdxA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 380
ILE A 408
TRP A 375
ARG A 383
 None
 1.17A 6hisA-5kdxA:
undetectable
6hisE-5kdxA:
undetectable		 6hisA-5kdxA:
7.00
6hisE-5kdxA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 8 TRP A 859
TYR A 831
ASP A 864
ARG A 866
 None
 1.09A 6hisA-5kdxA:
undetectable
6hisE-5kdxA:
undetectable		 6hisA-5kdxA:
7.00
6hisE-5kdxA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 10 SER A 877
GLY A 712
ALA A 777
ASN A 850
VAL A 709
 None
 1.31A 6hu9L-5kdxA:
undetectable
6hu9P-5kdxA:
undetectable
6hu9T-5kdxA:
undetectable		 6hu9L-5kdxA:
19.84
6hu9P-5kdxA:
12.21
6hu9T-5kdxA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  85
ILE A 118
ALA A 161
LEU A 125
LEU A 157
 None
 1.00A 6ie8A-5kdxA:
undetectable		 6ie8A-5kdxA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5kdx METALLOPEPTIDASE
(Pseudomonas
aeruginosa) 		4 / 7 LEU A 829
TYR A 887
THR A 861
LEU A 860
 None
 0.88A 6nmpA-5kdxA:
undetectable
6nmpJ-5kdxA:
undetectable		 6nmpA-5kdxA:
20.04
6nmpJ-5kdxA:
6.03