SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5keg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5keg DNA DC->DU-EDITING
ENZYME APOBEC-3A
(Homo
sapiens) 		5 / 12 LEU A  78
VAL A  79
SER A  81
HIS A 119
LEU A 114
 None
 1.35A 2zlcA-5kegA:
undetectable		 2zlcA-5kegA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 5keg DNA DC->DU-EDITING
ENZYME APOBEC-3A
(Homo
sapiens) 		4 / 7 GLY A 178
PHE A  95
PHE A 158
PHE A  18
 None
 0.85A 3ko0L-5kegA:
undetectable
3ko0N-5kegA:
undetectable		 3ko0L-5kegA:
19.10
3ko0N-5kegA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 5keg DNA DC->DU-EDITING
ENZYME APOBEC-3A
(Homo
sapiens) 		4 / 7 PHE A 158
PHE A  18
GLY A 178
PHE A  95
 None
 0.83A 3ko0R-5kegA:
undetectable
3ko0T-5kegA:
undetectable		 3ko0R-5kegA:
19.10
3ko0T-5kegA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 5keg DNA DC->DU-EDITING
ENZYME APOBEC-3A
(Homo
sapiens) 		4 / 7 ASP A 163
GLN A 169
PRO A 172
GLN A 174
 None
 1.17A 3l2vA-5kegA:
undetectable		 3l2vA-5kegA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 5keg DNA DC->DU-EDITING
ENZYME APOBEC-3A
(Homo
sapiens) 		5 / 12 ILE A 129
ILE A  96
ALA A 126
ALA A  72
PHE A 102
 None
None
None
CL  A 203 ( 4.4A)
None
 1.06A 4kicB-5kegA:
undetectable		 4kicB-5kegA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_F_EZLF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 5keg DNA DC->DU-EDITING
ENZYME APOBEC-3A
(Homo
sapiens) 		4 / 8 HIS A 119
VAL A  92
VAL A  37
LEU A  82
 None
 0.86A 5tt3F-5kegA:
undetectable		 5tt3F-5kegA:
20.73