SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kem'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3004_1
(SERUM ALBUMIN)		 5kem BDBV91 VARIABLE FAB
DOMAIN LIGHT CHAIN
(Homo
sapiens) 		4 / 6 PHE C  62
GLU C  81
LEU C  78
VAL C  19
 None
 1.07A 1hk1A-5kemC:
undetectable		 1hk1A-5kemC:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5kem EBOLA SECRETED
GLYCOPROTEIN
(Zaire
ebolavirus) 		5 / 12 ALA A 158
ALA A  82
THR A  77
VAL A  75
GLY A  74
 None
 1.19A 2ve3B-5kemA:
undetectable		 2ve3B-5kemA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5kem BDBV91 VARIABLE FAB
DOMAIN LIGHT CHAIN
(Homo
sapiens) 		4 / 7 PHE C  92
ARG C  24
MET C   4
THR C   5
 None
 1.05A 3ag2N-5kemC:
undetectable
3ag2W-5kemC:
undetectable		 3ag2N-5kemC:
11.18
3ag2W-5kemC:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		 5kem BDBV91 VARIABLE FAB
DOMAIN HEAVY CHAIN
(Homo
sapiens) 		5 / 12 GLY B  49
GLN B  61
VAL B  37
ARG B  64
PHE B  63
 None
 1.13A 3h52C-5kemB:
undetectable		 3h52C-5kemB:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5kem BDBV91 VARIABLE FAB
DOMAIN LIGHT CHAIN
(Homo
sapiens) 		5 / 12 PHE C  83
GLN C  37
LEU C  73
VAL C  19
ILE C  75
 None
 1.23A 4k38B-5kemC:
undetectable		 4k38B-5kemC:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5kem EBOLA SECRETED
GLYCOPROTEIN
(Zaire
ebolavirus) 		3 / 3 PRO A 133
VAL A 138
HIS A 139
 None
 0.71A 4pevC-5kemA:
undetectable		 4pevC-5kemA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 5kem BDBV91 VARIABLE FAB
DOMAIN HEAVY CHAIN
(Homo
sapiens) 		5 / 12 LEU B  82
LEU B  82
ILE B  51
TYR B  90
THR B 107
 None
 1.06A 5ienB-5kemB:
undetectable		 5ienB-5kemB:
23.40