SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ket'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5ket ALDO-KETO REDUCTASE
1
(Coptotermes
gestroi) 		5 / 11 LEU A 191
VAL A 211
MET A 316
TYR A 330
LEU A 200
 None
 1.42A 1kt6A-5ketA:
undetectable		 1kt6A-5ketA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 5ket ALDO-KETO REDUCTASE
1
(Coptotermes
gestroi) 		4 / 7 TYR A  52
HIS A 114
LEU A 115
TYR A 214
 NAP  A 400 (-4.8A)
NAP  A 400 (-4.3A)
None
NAP  A 400 (-3.6A)
 1.04A 1tuvA-5ketA:
undetectable		 1tuvA-5ketA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 5ket ALDO-KETO REDUCTASE
1
(Coptotermes
gestroi) 		4 / 5 ARG A 183
ILE A 173
VAL A 211
THR A   9
 None
 1.07A 3eigA-5ketA:
undetectable		 3eigA-5ketA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 5ket ALDO-KETO REDUCTASE
1
(Coptotermes
gestroi) 		3 / 3 ALA A 228
VAL A 225
GLN A  25
 None
 0.73A 3of4B-5ketA:
undetectable		 3of4B-5ketA:
22.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R43_A_ID8A332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5ket ALDO-KETO REDUCTASE
1
(Coptotermes
gestroi) 		5 / 12 TYR A  52
HIS A 114
ASN A 167
TYR A 214
PHE A 314
 NAP  A 400 (-4.8A)
NAP  A 400 (-4.3A)
NAP  A 400 (-3.3A)
NAP  A 400 (-3.6A)
NAP  A 400 (-4.6A)
 0.57A 3r43A-5ketA:
43.3		 3r43A-5ketA:
39.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R58_A_NPSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5ket ALDO-KETO REDUCTASE
1
(Coptotermes
gestroi) 		7 / 10 TYR A  52
HIS A 114
ASN A 167
TYR A 214
PHE A 314
PRO A 329
TYR A 330
 NAP  A 400 (-4.8A)
NAP  A 400 (-4.3A)
NAP  A 400 (-3.3A)
NAP  A 400 (-3.6A)
NAP  A 400 (-4.6A)
None
None
 1.01A 3r58A-5ketA:
42.4		 3r58A-5ketA:
39.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R6I_A_JMSA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5ket ALDO-KETO REDUCTASE
1
(Coptotermes
gestroi) 		5 / 12 TYR A  52
HIS A 114
ASN A 167
TYR A 214
PHE A 314
 NAP  A 400 (-4.8A)
NAP  A 400 (-4.3A)
NAP  A 400 (-3.3A)
NAP  A 400 (-3.6A)
NAP  A 400 (-4.6A)
 0.51A 3r6iA-5ketA:
42.2		 3r6iA-5ketA:
39.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R8G_A_IZPA409_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5ket ALDO-KETO REDUCTASE
1
(Coptotermes
gestroi) 		6 / 9 TYR A  52
HIS A 114
ASN A 167
TYR A 214
PHE A 314
PRO A 329
 NAP  A 400 (-4.8A)
NAP  A 400 (-4.3A)
NAP  A 400 (-3.3A)
NAP  A 400 (-3.6A)
NAP  A 400 (-4.6A)
None
 0.82A 3r8gA-5ketA:
42.2		 3r8gA-5ketA:
39.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3R94_A_FLRA332_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5ket ALDO-KETO REDUCTASE
1
(Coptotermes
gestroi) 		7 / 12 TYR A  52
HIS A 114
ASN A 167
TYR A 214
PHE A 314
PRO A 329
TYR A 330
 NAP  A 400 (-4.8A)
NAP  A 400 (-4.3A)
NAP  A 400 (-3.3A)
NAP  A 400 (-3.6A)
NAP  A 400 (-4.6A)
None
None
 1.05A 3r94A-5ketA:
42.1		 3r94A-5ketA:
39.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UG8_A_IMNA2001_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5ket ALDO-KETO REDUCTASE
1
(Coptotermes
gestroi) 		6 / 12 TYR A  52
HIS A 114
ASN A 167
TYR A 214
PRO A 329
TYR A 330
 NAP  A 400 (-4.8A)
NAP  A 400 (-4.3A)
NAP  A 400 (-3.3A)
NAP  A 400 (-3.6A)
None
None
 0.87A 3ug8A-5ketA:
42.3		 3ug8A-5ketA:
39.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5ket ALDO-KETO REDUCTASE
1
(Coptotermes
gestroi) 		4 / 7 ASN A 167
GLN A  25
PRO A 329
TYR A 330
 NAP  A 400 (-3.3A)
None
None
None
 1.22A 3ugrA-5ketA:
41.9		 3ugrA-5ketA:
39.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5ket ALDO-KETO REDUCTASE
1
(Coptotermes
gestroi) 		5 / 7 TYR A  52
ASN A 167
GLU A 190
PRO A 329
TYR A 330
 NAP  A 400 (-4.8A)
NAP  A 400 (-3.3A)
None
None
None
 0.84A 3ugrA-5ketA:
41.9		 3ugrA-5ketA:
39.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5ket ALDO-KETO REDUCTASE
1
(Coptotermes
gestroi) 		5 / 12 VAL A  79
PHE A  10
SER A 162
LEU A 165
THR A 210
 None
 1.48A 4iarA-5ketA:
undetectable		 4iarA-5ketA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 5ket ALDO-KETO REDUCTASE
1
(Coptotermes
gestroi) 		5 / 11 PHE A 119
GLY A  86
LEU A 115
GLY A 118
ALA A 237
 None
 1.02A 4l6v1-5ketA:
undetectable
4l6v6-5ketA:
undetectable		 4l6v1-5ketA:
17.95
4l6v6-5ketA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5ket ALDO-KETO REDUCTASE
1
(Coptotermes
gestroi) 		4 / 8 THR A  61
ILE A  78
LEU A  21
ILE A 283
 None
 0.72A 4r38A-5ketA:
undetectable		 4r38A-5ketA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 5ket ALDO-KETO REDUCTASE
1
(Coptotermes
gestroi) 		4 / 6 ASN A  54
ASP A  47
THR A  61
VAL A  31
 None
NAP  A 400 (-2.8A)
None
None
 0.99A 4yoaA-5ketA:
undetectable		 4yoaA-5ketA:
17.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YVV_A_GBMA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5ket ALDO-KETO REDUCTASE
1
(Coptotermes
gestroi) 		5 / 9 TYR A  52
HIS A 114
ASN A 167
TYR A 214
PHE A 314
 NAP  A 400 (-4.8A)
NAP  A 400 (-4.3A)
NAP  A 400 (-3.3A)
NAP  A 400 (-3.6A)
NAP  A 400 (-4.6A)
 0.51A 4yvvA-5ketA:
43.9		 4yvvA-5ketA:
39.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5ket ALDO-KETO REDUCTASE
1
(Coptotermes
gestroi) 		5 / 11 HIS A  45
THR A  48
THR A  80
GLY A  59
THR A  61
 None
 1.39A 5d0xV-5ketA:
undetectable
5d0xb-5ketA:
undetectable		 5d0xV-5ketA:
21.94
5d0xb-5ketA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5ket ALDO-KETO REDUCTASE
1
(Coptotermes
gestroi) 		5 / 11 HIS A  45
THR A  48
THR A  80
GLY A  59
THR A  61
 None
 1.39A 5d0xH-5ketA:
undetectable
5d0xN-5ketA:
undetectable		 5d0xH-5ketA:
21.94
5d0xN-5ketA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5ket ALDO-KETO REDUCTASE
1
(Coptotermes
gestroi) 		4 / 5 THR A  48
ALA A  49
THR A  80
TYR A 111
 None
 1.01A 5ecmA-5ketA:
2.0		 5ecmA-5ketA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5ket ALDO-KETO REDUCTASE
1
(Coptotermes
gestroi) 		4 / 6 THR A  48
ALA A  49
THR A  80
TYR A 111
 None
 0.94A 5ecoA-5ketA:
1.9		 5ecoA-5ketA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 5ket ALDO-KETO REDUCTASE
1
(Coptotermes
gestroi) 		4 / 8 ILE A 217
VAL A 193
GLU A 298
ALA A 251
 NAP  A 400 (-3.9A)
None
None
None
 0.64A 5og9A-5ketA:
undetectable		 5og9A-5ketA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 5ket ALDO-KETO REDUCTASE
1
(Coptotermes
gestroi) 		5 / 9 LEU A  62
PHE A  66
ASP A  67
VAL A  76
ILE A  78
 None
 1.18A 5om2A-5ketA:
undetectable
5om2B-5ketA:
undetectable		 5om2A-5ketA:
14.41
5om2B-5ketA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 5ket ALDO-KETO REDUCTASE
1
(Coptotermes
gestroi) 		4 / 4 PHE A  10
LEU A  96
LEU A 112
VAL A 155
 None
 1.32A 5xxiA-5ketA:
undetectable		 5xxiA-5ketA:
21.97