SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kf2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 5kf2 PREDICTED
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 6 TRP A 288
THR A 118
GLY A 115
TYR A  77
 None
None
ACO  A 402 ( 4.7A)
None
 1.30A 1gtiC-5kf2A:
undetectable		 1gtiC-5kf2A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 5kf2 PREDICTED
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 7 TYR A  24
VAL A 285
ILE A 151
GLU A 128
 None
 0.84A 1j96B-5kf2A:
undetectable		 1j96B-5kf2A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACHA546_0
(ACETYLCHOLINESTERASE)		 5kf2 PREDICTED
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 8 TYR A 226
TYR A 297
PHE A 197
GLY A 254
 None
None
None
COA  A 401 (-3.3A)
 1.07A 2ha4A-5kf2A:
undetectable		 2ha4A-5kf2A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 5kf2 PREDICTED
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 5 ILE A  81
PHE A 122
PHE A 121
ILE A  20
 ACO  A 402 (-4.5A)
None
None
None
 1.16A 2hjhA-5kf2A:
undetectable		 2hjhA-5kf2A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 5kf2 PREDICTED
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 7 LEU A 212
ASN A 171
GLU A 271
LEU A 267
 None
 1.15A 2w8yA-5kf2A:
undetectable		 2w8yA-5kf2A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 5kf2 PREDICTED
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 HIS A 224
ILE A 237
LEU A 242
ASP A 149
TYR A 308
 None
 1.11A 4foxB-5kf2A:
undetectable		 4foxB-5kf2A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5kf2 PREDICTED
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 ASN A  49
ILE A  81
ILE A  82
ASN A  19
SER A  80
 None
ACO  A 402 (-4.5A)
ACO  A 402 (-4.4A)
EDO  A 403 (-4.7A)
None
 1.45A 4xueA-5kf2A:
undetectable		 4xueA-5kf2A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5kf2 PREDICTED
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 7 PHE A 184
ILE A 220
PHE A 189
GLY A 254
 None
None
COA  A 401 (-4.8A)
COA  A 401 (-3.3A)
 0.94A 4zdzA-5kf2A:
undetectable		 4zdzA-5kf2A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5kf2 PREDICTED
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 7 PHE A 184
ILE A 220
PHE A 189
GLY A 254
 None
None
COA  A 401 (-4.8A)
COA  A 401 (-3.3A)
 0.92A 5esmA-5kf2A:
undetectable		 5esmA-5kf2A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 5kf2 PREDICTED
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 ILE A  81
LEU A 104
ASP A 117
GLY A 115
ILE A  58
 ACO  A 402 (-4.5A)
EDO  A 404 (-4.2A)
None
ACO  A 402 ( 4.7A)
None
 1.04A 5j7wD-5kf2A:
undetectable		 5j7wD-5kf2A:
22.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 5kf2 PREDICTED
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		8 / 8 ARG A 192
TRP A 193
GLU A 196
PRO A 235
GLY A 251
PRO A 252
ASP A 287
TRP A 288
 None
PO4  A 405 (-3.7A)
None
None
None
None
None
None
 0.28A 5kf8A-5kf2A:
52.0		 5kf8A-5kf2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 5kf2 PREDICTED
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 8 TRP A 193
PRO A 236
PRO A 252
ASP A 287
TRP A 288
 PO4  A 405 (-3.7A)
None
None
None
None
 1.45A 5kf8A-5kf2A:
52.0		 5kf8A-5kf2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KGJ_A_X6XA402_1
(PREDICTED
ACETYLTRANSFERASE)		 5kf2 PREDICTED
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 5 ARG A 192
TRP A 193
GLU A 196
ASP A 287
TRP A 288
 None
PO4  A 405 (-3.7A)
None
None
None
 0.11A 5kgjA-5kf2A:
52.2		 5kgjA-5kf2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 5kf2 PREDICTED
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		8 / 8 ARG A 192
TRP A 193
GLU A 196
PRO A 235
GLY A 251
PRO A 252
ASP A 287
TRP A 288
 None
PO4  A 405 (-3.7A)
None
None
None
None
None
None
 0.28A 5kgpA-5kf2A:
51.0		 5kgpA-5kf2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 5kf2 PREDICTED
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 8 TRP A 193
PRO A 236
PRO A 252
ASP A 287
TRP A 288
 PO4  A 405 (-3.7A)
None
None
None
None
 1.49A 5kgpA-5kf2A:
51.0		 5kgpA-5kf2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KGP_A_PA1A406_1
(PREDICTED
ACETYLTRANSFERASE)		 5kf2 PREDICTED
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 4 ARG A 192
TRP A 193
TRP A 288
GLU A 290
 None
PO4  A 405 (-3.7A)
None
None
 0.32A 5kgpA-5kf2A:
51.0		 5kgpA-5kf2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 5kf2 PREDICTED
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		8 / 8 ARG A 192
TRP A 193
GLU A 196
PRO A 235
GLY A 251
PRO A 252
ASP A 287
TRP A 288
 None
PO4  A 405 (-3.7A)
None
None
None
None
None
None
 0.30A 5kgpB-5kf2A:
50.7		 5kgpB-5kf2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KGP_B_GCSB405_1
(PREDICTED
ACETYLTRANSFERASE)		 5kf2 PREDICTED
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 8 TRP A 193
PRO A 236
PRO A 252
ASP A 287
TRP A 288
 PO4  A 405 (-3.7A)
None
None
None
None
 1.49A 5kgpB-5kf2A:
50.7		 5kgpB-5kf2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5KGP_B_PA1B404_1
(PREDICTED
ACETYLTRANSFERASE)		 5kf2 PREDICTED
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 4 ARG A 192
TRP A 193
TRP A 288
GLU A 290
 None
PO4  A 405 (-3.7A)
None
None
 0.33A 5kgpB-5kf2A:
50.7		 5kgpB-5kf2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 5kf2 PREDICTED
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 ILE A  20
ILE A  82
ASP A  84
ILE A  85
LEU A  15
 None
ACO  A 402 (-4.4A)
None
EDO  A 403 (-4.7A)
None
 0.95A 5uvmB-5kf2A:
2.0		 5uvmB-5kf2A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCE_A_RITA602_1
(CYTOCHROME P450 3A4)		 5kf2 PREDICTED
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 PHE A 136
ILE A  78
ALA A 100
ILE A   3
ALA A  47
 None
 1.13A 5vceA-5kf2A:
undetectable		 5vceA-5kf2A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5kf2 PREDICTED
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		5 / 12 TRP A 193
LEU A 250
PHE A 200
HIS A 120
THR A 289
 PO4  A 405 (-3.7A)
None
None
None
None
 1.40A 6djzB-5kf2A:
undetectable		 6djzB-5kf2A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)		 5kf2 PREDICTED
ACETYLTRANSFERASE
(Clostridium
acetobutylicum) 		4 / 8 GLY A 254
LEU A 264
GLY A 265
LEU A 268
 COA  A 401 (-3.3A)
None
COA  A 401 (-3.4A)
None
 0.85A 6mdqA-5kf2A:
undetectable		 6mdqA-5kf2A:
11.76