SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kf7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		3 / 3 ALA A 341
VAL A 391
TRP A 374
 None
None
FAD  A2001 (-3.6A)
 0.81A 1av2A-5kf7A:
undetectable
1av2B-5kf7A:
undetectable		 1av2A-5kf7A:
1.64
1av2B-5kf7A:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		3 / 3 TRP A 374
ALA A 341
VAL A 391
 FAD  A2001 (-3.6A)
None
None
 0.94A 1av2C-5kf7A:
undetectable
1av2D-5kf7A:
undetectable		 1av2C-5kf7A:
1.64
1av2D-5kf7A:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 5 TYR A 485
LEU A 449
VAL A 338
ASP A 306
 TFB  A2003 (-4.9A)
FAD  A2001 (-4.1A)
FAD  A2001 (-4.3A)
TFB  A2003 ( 3.5A)
 1.29A 1dz6A-5kf7A:
undetectable		 1dz6A-5kf7A:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 12 ILE A 712
PHE A 713
GLY A 715
LEU A 758
LEU A 756
 None
 1.22A 1fm6X-5kf7A:
undetectable		 1fm6X-5kf7A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_A_HSMA502_1
(HISTIDINOL
DEHYDROGENASE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 9 LEU A1026
HIS A1041
TYR A1094
GLU A1213
LEU A1096
 None
 1.30A 1karA-5kf7A:
6.2
1karB-5kf7A:
6.2		 1karA-5kf7A:
17.85
1karB-5kf7A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KAR_B_HSMB503_1
(HISTIDINOL
DEHYDROGENASE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 9 GLU A1213
LEU A1096
LEU A1026
HIS A1041
TYR A1094
 None
 1.23A 1karA-5kf7A:
6.1
1karB-5kf7A:
6.3		 1karA-5kf7A:
17.85
1karB-5kf7A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 6 ASP A 221
GLY A 261
ILE A 301
ILE A 201
 None
 0.88A 1n49D-5kf7A:
undetectable		 1n49D-5kf7A:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 6 ARG A 488
ALA A 372
TYR A 485
GLU A 492
 TFB  A2003 (-3.8A)
FAD  A2001 (-3.5A)
TFB  A2003 (-4.9A)
FAD  A2001 (-2.7A)
 1.29A 1oniB-5kf7A:
undetectable
1oniC-5kf7A:
undetectable		 1oniB-5kf7A:
8.27
1oniC-5kf7A:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_F_BEZF511_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 5 TYR A 485
GLU A 492
ARG A 488
ALA A 372
 TFB  A2003 (-4.9A)
FAD  A2001 (-2.7A)
TFB  A2003 (-3.8A)
FAD  A2001 (-3.5A)
 1.28A 1oniE-5kf7A:
undetectable
1oniF-5kf7A:
undetectable		 1oniE-5kf7A:
8.27
1oniF-5kf7A:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OXR_A_AINA141_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 4 LEU A 269
GLY A 224
ASP A 221
TYR A 240
 None
 1.20A 1oxrA-5kf7A:
0.8		 1oxrA-5kf7A:
5.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 12 GLY A 259
ILE A 247
ALA A 250
SER A 217
TYR A 218
 None
 1.15A 1ri4A-5kf7A:
undetectable		 1ri4A-5kf7A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 5 GLY A 655
ILE A 657
TRP A 574
VAL A 602
 None
 0.88A 1rs7A-5kf7A:
undetectable		 1rs7A-5kf7A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 6 GLY A 655
ILE A 657
TRP A 574
VAL A 602
 None
 0.90A 1rs7B-5kf7A:
undetectable		 1rs7B-5kf7A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB504_1
(YKOF)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 6 PRO A 595
LEU A 654
ILE A 658
SER A 569
 None
 1.20A 1sbrA-5kf7A:
undetectable
1sbrB-5kf7A:
undetectable		 1sbrA-5kf7A:
9.64
1sbrB-5kf7A:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV5_A_65BA600_0
(REVERSE
TRANSCRIPTASE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 10 LEU A1112
PRO A1142
TRP A1151
LEU A1138
TYR A1113
 None
 1.07A 1sv5A-5kf7A:
1.6		 1sv5A-5kf7A:
18.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TJ2_A_ACTA2002_0
(BIFUNCTIONAL PUTA
PROTEIN)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 5 LYS A 265
ALA A 372
TYR A 485
ARG A 488
ARG A 489
 TFB  A2003 (-2.8A)
FAD  A2001 (-3.5A)
TFB  A2003 (-4.9A)
TFB  A2003 (-3.8A)
TFB  A2003 ( 2.6A)
 0.37A 1tj2A-5kf7A:
62.5		 1tj2A-5kf7A:
32.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		3 / 3 ALA A 341
VAL A 391
TRP A 374
 None
None
FAD  A2001 (-3.6A)
 0.85A 1w5uA-5kf7A:
undetectable
1w5uB-5kf7A:
undetectable		 1w5uA-5kf7A:
1.64
1w5uB-5kf7A:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		3 / 3 TRP A 374
ALA A 341
VAL A 391
 FAD  A2001 (-3.6A)
None
None
 0.83A 1w5uA-5kf7A:
undetectable
1w5uB-5kf7A:
undetectable		 1w5uA-5kf7A:
1.64
1w5uB-5kf7A:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		3 / 3 ASP A 306
GLU A 492
TYR A 402
 TFB  A2003 ( 3.5A)
FAD  A2001 (-2.7A)
None
 0.73A 1wsvA-5kf7A:
undetectable		 1wsvA-5kf7A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 12 LEU A 710
ALA A 732
ARG A 590
LEU A 758
THR A 714
 None
NAD  A2002 (-3.9A)
None
None
None
 1.22A 1ya3B-5kf7A:
undetectable		 1ya3B-5kf7A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 12 LEU A 104
LEU A 164
ALA A 167
GLN A  96
SER A  94
 None
None
SO4  A2008 ( 3.8A)
None
SO4  A2008 (-2.7A)
 1.41A 2aa5B-5kf7A:
undetectable		 2aa5B-5kf7A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 12 LEU A 697
VAL A 727
ILE A 717
GLY A 715
ILE A 700
 None
 0.82A 2avsA-5kf7A:
undetectable		 2avsA-5kf7A:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 9 LEU A 317
LEU A 319
LEU A 320
ILE A 305
TYR A 273
 None
 1.21A 2f78B-5kf7A:
2.1		 2f78B-5kf7A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 9 LEU A 317
LEU A 319
LEU A 320
ILE A 305
TYR A 273
 None
 1.24A 2f7aB-5kf7A:
2.0		 2f7aB-5kf7A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 11 ILE A 247
GLU A 212
GLY A 255
ARG A 471
GLY A 248
 None
 1.47A 2fn1B-5kf7A:
undetectable		 2fn1B-5kf7A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		3 / 3 TRP A 374
ALA A 341
VAL A 391
 FAD  A2001 (-3.6A)
None
None
 0.87A 2izqC-5kf7A:
undetectable
2izqD-5kf7A:
undetectable		 2izqC-5kf7A:
1.64
2izqD-5kf7A:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 9 GLY A1011
SER A1016
ILE A1000
ILE A 989
VAL A 985
 None
 1.07A 2nnhB-5kf7A:
undetectable		 2nnhB-5kf7A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 12 LEU A 710
ALA A 732
ARG A 590
LEU A 758
THR A 714
 None
NAD  A2002 (-3.9A)
None
None
None
 1.19A 2oaxB-5kf7A:
undetectable		 2oaxB-5kf7A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 12 LEU A 710
ALA A 732
ARG A 590
LEU A 758
THR A 714
 None
NAD  A2002 (-3.9A)
None
None
None
 1.25A 2oaxC-5kf7A:
undetectable		 2oaxC-5kf7A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 10 ALA A 749
GLU A 748
LEU A 645
MET A 646
ARG A 744
 None
 1.49A 2ocfA-5kf7A:
undetectable		 2ocfA-5kf7A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 7 VAL A 886
ALA A 891
PRO A 926
THR A 927
 None
 0.87A 2q6oA-5kf7A:
undetectable		 2q6oA-5kf7A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA504_0
(CHORISMATE SYNTHASE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 5 SER A 219
ARG A 367
LEU A 303
SER A 263
 None
FAD  A2001 (-4.1A)
None
None
 1.42A 2qhfA-5kf7A:
undetectable		 2qhfA-5kf7A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 12 LEU A 697
VAL A 727
ILE A 717
GLY A 715
ILE A 700
 None
 0.84A 2r5pA-5kf7A:
undetectable		 2r5pA-5kf7A:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 12 LEU A 697
VAL A 727
ILE A 717
GLY A 715
ILE A 700
 None
 0.84A 2r5pC-5kf7A:
undetectable		 2r5pC-5kf7A:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 7 LYS A 265
SER A 219
ASP A 221
ARG A 367
 TFB  A2003 (-2.8A)
None
None
FAD  A2001 (-4.1A)
 1.48A 2rk8B-5kf7A:
undetectable		 2rk8B-5kf7A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 7 THR A 398
VAL A 400
SER A 401
GLU A  43
 FAD  A2001 (-3.4A)
None
None
None
 1.02A 2v2gA-5kf7A:
undetectable
2v2gB-5kf7A:
undetectable		 2v2gA-5kf7A:
12.11
2v2gB-5kf7A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 7 THR A 398
VAL A 400
SER A 401
GLU A  43
 FAD  A2001 (-3.4A)
None
None
None
 1.05A 2v2gC-5kf7A:
undetectable
2v2gD-5kf7A:
undetectable		 2v2gC-5kf7A:
12.11
2v2gD-5kf7A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 7 THR A 927
GLU A 896
ARG A 903
PRO A 925
 None
 1.07A 2v2gC-5kf7A:
undetectable
2v2gD-5kf7A:
undetectable		 2v2gC-5kf7A:
12.11
2v2gD-5kf7A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 7 PRO A 925
THR A 927
GLU A 896
ARG A 903
 None
 1.05A 2v2gC-5kf7A:
undetectable
2v2gD-5kf7A:
undetectable		 2v2gC-5kf7A:
12.11
2v2gD-5kf7A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 8 THR A 927
GLU A 896
ARG A 903
PRO A 925
 None
 1.00A 2v41G-5kf7A:
undetectable
2v41H-5kf7A:
undetectable		 2v41G-5kf7A:
12.11
2v41H-5kf7A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 8 PRO A 925
THR A 927
GLU A 896
ARG A 903
 None
 0.99A 2v41G-5kf7A:
undetectable
2v41H-5kf7A:
undetectable		 2v41G-5kf7A:
12.11
2v41H-5kf7A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 12 THR A 156
SER A 163
VAL A  99
GLY A 148
ALA A 144
 None
SO4  A2008 ( 4.3A)
None
None
None
 0.89A 2x2iA-5kf7A:
6.2		 2x2iA-5kf7A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 12 THR A 156
SER A 163
VAL A  99
GLY A 148
ALA A 144
 None
SO4  A2008 ( 4.3A)
None
None
None
 0.86A 2x2iC-5kf7A:
2.1		 2x2iC-5kf7A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 10 THR A 927
VAL A 909
ASN A 894
VAL A 941
GLY A 943
 None
 1.42A 2x2iD-5kf7A:
4.9		 2x2iD-5kf7A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 12 GLY A 992
GLY A1012
LEU A 970
LEU A 994
GLU A1213
 None
None
NAD  A2002 ( 4.8A)
None
None
 1.18A 2zw9B-5kf7A:
undetectable		 2zw9B-5kf7A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		6 / 9 LEU A 756
ILE A 712
ILE A 738
PRO A 731
ALA A 729
ILE A 717
 None
 1.18A 3el0B-5kf7A:
undetectable		 3el0B-5kf7A:
5.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_1
(GLUCOCORTICOID
RECEPTOR)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 10 ASN A 493
MET A 190
LEU A 482
TYR A 485
LEU A 490
 None
None
None
TFB  A2003 (-4.9A)
None
 1.46A 3h52B-5kf7A:
0.0		 3h52B-5kf7A:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE P)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 8 VAL A 461
VAL A 441
ILE A 472
GLY A 215
 None
 0.92A 3hjoA-5kf7A:
undetectable		 3hjoA-5kf7A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		3 / 3 GLU A 674
GLY A 715
THR A 714
 PG4  A2005 (-3.8A)
None
None
 0.56A 3iazA-5kf7A:
undetectable		 3iazA-5kf7A:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 8 TYR A  39
GLU A 377
SER A 316
ILE A 305
 None
 1.07A 3jz0B-5kf7A:
undetectable		 3jz0B-5kf7A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		3 / 3 ARG A 673
THR A 876
THR A 834
 None
 0.71A 3k2hB-5kf7A:
undetectable		 3k2hB-5kf7A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		3 / 3 ALA A1170
ARG A1174
LYS A1178
 None
 0.89A 3kp5B-5kf7A:
undetectable		 3kp5B-5kf7A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		3 / 3 TRP A 374
ALA A 341
VAL A 391
 FAD  A2001 (-3.6A)
None
None
 0.84A 3l8lC-5kf7A:
undetectable
3l8lD-5kf7A:
undetectable		 3l8lC-5kf7A:
1.64
3l8lD-5kf7A:
2.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		3 / 3 ASP A 855
SER A 821
ARG A 138
 None
 0.99A 3loqA-5kf7A:
undetectable		 3loqA-5kf7A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		3 / 3 GLY A 655
TRP A 574
VAL A 602
 None
 0.75A 3n62B-5kf7A:
undetectable		 3n62B-5kf7A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		3 / 3 GLY A 655
TRP A 574
VAL A 602
 None
 0.73A 3n65B-5kf7A:
undetectable		 3n65B-5kf7A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		3 / 3 GLY A 655
TRP A 574
VAL A 602
 None
 0.74A 3n66B-5kf7A:
undetectable		 3n66B-5kf7A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 12 ALA A 276
ASP A 877
ASP A 882
VAL A 881
GLU A 870
 None
 1.04A 3nvkI-5kf7A:
2.4		 3nvkI-5kf7A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 12 ARG A 744
GLY A 742
PHE A 678
GLU A 748
ALA A 642
 None
 1.35A 3t7sD-5kf7A:
undetectable		 3t7sD-5kf7A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_1
(PROTEASE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 12 ARG A 788
GLY A1163
ALA A1164
VAL A1176
ILE A1180
 None
 0.98A 3tkwA-5kf7A:
undetectable		 3tkwA-5kf7A:
6.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_A_SALA404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 7 ALA A 642
ARG A 545
ALA A 683
ARG A 687
 None
 0.89A 3twpA-5kf7A:
2.7		 3twpA-5kf7A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 7 ALA A 642
ARG A 545
ALA A 683
ARG A 687
 None
 1.02A 3twpB-5kf7A:
2.4		 3twpB-5kf7A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		3 / 3 PHE A 708
LYS A 663
SER A 664
 PG4  A2005 (-3.7A)
None
None
 1.39A 3tyeB-5kf7A:
7.7		 3tyeB-5kf7A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFG_B_LEUB289_0
(GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		3 / 3 PHE A1161
SER A1150
SER A1152
 None
 0.95A 3ufgB-5kf7A:
undetectable		 3ufgB-5kf7A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_B_ESTB600_1
(ESTROGEN RECEPTOR)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 10 ALA A 749
GLU A 748
LEU A 645
MET A 646
ARG A 744
 None
 1.50A 3uudB-5kf7A:
undetectable		 3uudB-5kf7A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		3 / 3 ARG A 903
GLU A 910
THR A 927
 None
 0.91A 3v4tA-5kf7A:
0.2		 3v4tA-5kf7A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 5 SER A 330
GLY A 331
TRP A 332
ASP A 300
 None
 1.39A 3w9tB-5kf7A:
undetectable		 3w9tB-5kf7A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 5 SER A 330
GLY A 331
TRP A 332
ASP A 300
 None
 1.39A 3w9tC-5kf7A:
undetectable		 3w9tC-5kf7A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 5 SER A 330
GLY A 331
TRP A 332
ASP A 300
 None
 1.38A 3w9tD-5kf7A:
undetectable		 3w9tD-5kf7A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 11 GLN A1191
ASN A1201
PRO A 804
ALA A1170
GLY A 802
 None
 1.31A 4a6nA-5kf7A:
undetectable		 4a6nA-5kf7A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 5 GLY A 655
ILE A 657
TRP A 574
VAL A 602
 None
 0.76A 4d33A-5kf7A:
undetectable		 4d33A-5kf7A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 5 GLY A 655
ILE A 657
TRP A 574
VAL A 602
 None
 0.79A 4d33B-5kf7A:
undetectable		 4d33B-5kf7A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 6 GLY A 655
ILE A 657
TRP A 574
VAL A 602
 None
 0.78A 4d39B-5kf7A:
undetectable		 4d39B-5kf7A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 12 ALA A 276
ALA A  22
ASP A 877
ASP A 882
VAL A 881
 None
 1.21A 4df3A-5kf7A:
3.1		 4df3A-5kf7A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 12 PHE A 972
LEU A 956
ILE A 818
THR A 976
THR A 981
 None
 1.08A 4enhA-5kf7A:
undetectable		 4enhA-5kf7A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		3 / 3 ASP A 962
ARG A 958
ASP A 936
 None
 0.85A 4fp9C-5kf7A:
3.0		 4fp9C-5kf7A:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 5 ILE A 264
LEU A 266
LYS A 265
ASN A 304
 None
None
TFB  A2003 (-2.8A)
None
 1.12A 4g19A-5kf7A:
undetectable		 4g19A-5kf7A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 8 VAL A 602
ASN A 594
PRO A 595
ILE A 738
 None
 1.11A 4iilA-5kf7A:
undetectable		 4iilA-5kf7A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 6 GLY A 655
ILE A 657
TRP A 574
VAL A 602
 None
 0.88A 4kcnA-5kf7A:
undetectable		 4kcnA-5kf7A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 6 GLU A 309
ARG A 380
ASP A 311
ASP A 384
 None
 1.00A 4kcnB-5kf7A:
undetectable		 4kcnB-5kf7A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 6 SER A 783
GLY A 761
ASP A 762
GLY A 766
 NAD  A2002 (-2.6A)
None
None
NAD  A2002 (-3.6A)
 1.04A 4koeA-5kf7A:
undetectable
4koeB-5kf7A:
undetectable
4koeC-5kf7A:
2.2		 4koeA-5kf7A:
18.12
4koeB-5kf7A:
18.12
4koeC-5kf7A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 4 VAL A 605
THR A 589
GLU A 607
GLU A 588
 None
 1.00A 4l78A-5kf7A:
undetectable		 4l78A-5kf7A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 4 VAL A 605
THR A 606
GLU A 607
GLU A 588
 None
 1.21A 4l78A-5kf7A:
undetectable		 4l78A-5kf7A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 6 GLU A 890
VAL A 592
THR A 591
ARG A 590
 None
 1.15A 4lnxA-5kf7A:
undetectable		 4lnxA-5kf7A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 7 ARG A 878
ILE A 658
PHE A  18
ASP A 600
 None
 0.78A 4mmcA-5kf7A:
1.0		 4mmcA-5kf7A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_B_MXMB807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		6 / 12 LEU A 946
ARG A 848
ILE A 833
PHE A 708
ALA A 846
LEU A 847
 None
None
None
PG4  A2005 (-3.7A)
None
None
 1.47A 4o1zB-5kf7A:
0.5		 4o1zB-5kf7A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		6 / 12 LEU A 879
LEU A 551
LEU A 654
ILE A 658
LEU A 566
PHE A  21
 None
 1.47A 4odrA-5kf7A:
undetectable
4odrB-5kf7A:
undetectable		 4odrA-5kf7A:
6.32
4odrB-5kf7A:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		6 / 11 LEU A 879
LEU A 551
LEU A 654
ILE A 658
LEU A 566
PHE A  21
 None
 1.44A 4odrA-5kf7A:
undetectable
4odrB-5kf7A:
undetectable		 4odrA-5kf7A:
6.32
4odrB-5kf7A:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB301_1
(CHITOSANASE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		3 / 3 GLY A 884
PRO A 885
GLN A 842
 None
 0.54A 4oltB-5kf7A:
0.2		 4oltB-5kf7A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		3 / 3 GLY A 884
PRO A 885
GLN A 842
 None
 0.36A 4qwpB-5kf7A:
undetectable		 4qwpB-5kf7A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 7 LEU A 266
ALA A 293
LEU A 323
LEU A 320
 None
 0.85A 4ubsA-5kf7A:
undetectable		 4ubsA-5kf7A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA305_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 6 LEU A 317
LEU A 320
GLU A 321
ILE A 353
 None
 0.96A 4ww7A-5kf7A:
undetectable		 4ww7A-5kf7A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 5 GLY A 969
ARG A1013
GLY A 992
GLU A1212
 None
 0.97A 4z2eB-5kf7A:
undetectable
4z2eC-5kf7A:
2.2		 4z2eB-5kf7A:
16.96
4z2eC-5kf7A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 6 ILE A 712
PRO A 705
ILE A 790
VAL A 778
 None
NAD  A2002 (-4.3A)
None
None
 1.01A 4zj8A-5kf7A:
undetectable		 4zj8A-5kf7A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 6 ILE A 929
HIS A 869
ILE A 833
VAL A 832
 None
 1.01A 4zj8A-5kf7A:
undetectable		 4zj8A-5kf7A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		3 / 3 ASP A 384
GLU A 377
SER A 664
 None
 0.81A 5bw4B-5kf7A:
3.9		 5bw4B-5kf7A:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_NPSA602_1
(SERUM ALBUMIN)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 12 LEU A 978
LEU A 956
ARG A 953
TYR A 951
LEU A 974
 None
 1.01A 5dbyA-5kf7A:
undetectable		 5dbyA-5kf7A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 9 ALA A 749
GLU A 748
LEU A 645
MET A 646
ARG A 744
 None
 1.49A 5dx3B-5kf7A:
undetectable		 5dx3B-5kf7A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 10 ALA A 749
GLU A 748
LEU A 645
MET A 646
ARG A 744
 None
 1.48A 5dxeB-5kf7A:
undetectable		 5dxeB-5kf7A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 9 GLN A1191
LEU A1165
VAL A1211
ARG A1099
ALA A1119
 None
 1.34A 5g44A-5kf7A:
undetectable		 5g44A-5kf7A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 6 ARG A 272
ALA A 230
PRO A 271
GLU A 284
 None
 1.29A 5odqA-5kf7A:
2.9		 5odqA-5kf7A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 10 TYR A 218
ILE A 247
ILE A 244
LEU A 292
HIS A 450
 None
 1.24A 5vkqA-5kf7A:
1.8
5vkqD-5kf7A:
undetectable		 5vkqA-5kf7A:
23.33
5vkqD-5kf7A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 10 HIS A 450
TYR A 218
ILE A 247
ILE A 244
LEU A 292
 None
 1.25A 5vkqA-5kf7A:
undetectable
5vkqB-5kf7A:
1.8		 5vkqA-5kf7A:
23.33
5vkqB-5kf7A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 10 HIS A 450
TYR A 218
ILE A 247
ILE A 244
LEU A 292
 None
 1.22A 5vkqC-5kf7A:
undetectable
5vkqD-5kf7A:
undetectable		 5vkqC-5kf7A:
23.33
5vkqD-5kf7A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		3 / 3 GLY A 655
TRP A 574
VAL A 602
 None
 0.76A 5vuoB-5kf7A:
undetectable		 5vuoB-5kf7A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 9 ALA A 749
GLU A 748
LEU A 645
MET A 646
ARG A 744
 None
 1.45A 5wgqA-5kf7A:
undetectable		 5wgqA-5kf7A:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGQ_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 10 ALA A 749
GLU A 748
LEU A 645
MET A 646
ARG A 744
 None
 1.48A 5wgqB-5kf7A:
undetectable		 5wgqB-5kf7A:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		3 / 3 THR A1108
GLU A1167
HIS A1114
 None
 0.81A 5xiqB-5kf7A:
undetectable		 5xiqB-5kf7A:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 12 PHE A 195
GLN A 194
LEU A  87
MET A 102
LEU A 490
 None
 1.22A 5y2tA-5kf7A:
undetectable		 5y2tA-5kf7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		3 / 3 LYS A 379
LEU A 383
ARG A 380
 1PE  A2007 (-2.7A)
None
None
 0.82A 5yw0A-5kf7A:
undetectable		 5yw0A-5kf7A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 10 LEU A 205
SER A 208
ILE A 247
SER A 217
GLY A 261
 None
 1.31A 6dlzA-5kf7A:
undetectable
6dlzD-5kf7A:
undetectable		 6dlzA-5kf7A:
5.15
6dlzD-5kf7A:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 10 ILE A 247
SER A 217
GLY A 261
LEU A 205
SER A 208
 None
 1.31A 6dlzB-5kf7A:
undetectable
6dlzC-5kf7A:
undetectable		 6dlzB-5kf7A:
5.15
6dlzC-5kf7A:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 10 LEU A 205
SER A 208
ILE A 247
SER A 217
GLY A 261
 None
 1.32A 6dm1A-5kf7A:
undetectable
6dm1D-5kf7A:
undetectable		 6dm1A-5kf7A:
5.15
6dm1D-5kf7A:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		5 / 10 ILE A 247
SER A 217
GLY A 261
LEU A 205
SER A 208
 None
 1.31A 6dm1B-5kf7A:
undetectable
6dm1C-5kf7A:
undetectable		 6dm1B-5kf7A:
5.15
6dm1C-5kf7A:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 8 ASP A 306
MET A 222
TYR A 473
VAL A 196
 TFB  A2003 ( 3.5A)
None
TFB  A2003 ( 3.6A)
None
 1.06A 6giqL-5kf7A:
undetectable
6giqP-5kf7A:
undetectable
6giqT-5kf7A:
undetectable		 6giqL-5kf7A:
17.71
6giqP-5kf7A:
11.08
6giqT-5kf7A:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N7F_A_RBFA502_0
(PUTATIVE GLUTATHIONE
REDUCTASE (GR))		 5kf7 BIFUNCTIONAL PROTEIN
PUTA
(Sinorhizobium
meliloti) 		4 / 7 GLY A1006
ASN A 547
GLU A 539
GLY A 542
 None
 0.83A 6n7fA-5kf7A:
undetectable		 6n7fA-5kf7A:
5.43