SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kgn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		4 / 5 ASP A 426
HIS A 430
HIS A 468
HIS A 485
 MN  A 604 (-2.2A)
MN  A 604 (-3.4A)
ZN  A 605 (-3.1A)
MN  A 604 (-3.3A)
 0.53A 1ei6A-5kgnA:
17.9		 1ei6A-5kgnA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 8 ASP A  37
ASP A 426
HIS A 430
HIS A 468
HIS A 485
 ZN  A 605 (-2.0A)
MN  A 604 (-2.2A)
MN  A 604 (-3.4A)
ZN  A 605 (-3.1A)
MN  A 604 (-3.3A)
 0.55A 1ei6C-5kgnA:
18.2		 1ei6C-5kgnA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		3 / 3 ASP A 286
ASP A 282
ASP A 217
 GOL  A 602 ( 4.8A)
None
None
 0.76A 1eizA-5kgnA:
2.4		 1eizA-5kgnA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		3 / 3 ASP A 286
ASP A 282
ASP A 217
 GOL  A 602 ( 4.8A)
None
None
 0.74A 1ej0A-5kgnA:
2.4		 1ej0A-5kgnA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		4 / 6 GLY A  84
GLY A  40
TYR A 488
SER A  86
 None
None
None
ZN  A 605 (-1.9A)
 0.85A 1eswA-5kgnA:
undetectable		 1eswA-5kgnA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 GLY A 139
ALA A 213
HIS A 136
THR A 206
ALA A 226
 None
 1.12A 1gtnO-5kgnA:
undetectable
1gtnP-5kgnA:
undetectable		 1gtnO-5kgnA:
11.00
1gtnP-5kgnA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 GLY A 139
ALA A 213
HIS A 136
THR A 206
ALA A 226
 None
 1.19A 1gtnU-5kgnA:
undetectable
1gtnV-5kgnA:
undetectable		 1gtnU-5kgnA:
11.00
1gtnV-5kgnA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		4 / 6 MET A 427
ALA A 423
GLU A 356
GLU A 358
 None
 1.26A 1qhyA-5kgnA:
2.5		 1qhyA-5kgnA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		4 / 6 LEU A 156
VAL A 157
ILE A 160
TYR A 321
 None
 0.69A 1s9qA-5kgnA:
undetectable		 1s9qA-5kgnA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 GLY A 139
ALA A 213
HIS A 136
THR A 206
ALA A 226
 None
 1.18A 1utdT-5kgnA:
undetectable
1utdU-5kgnA:
undetectable		 1utdT-5kgnA:
11.00
1utdU-5kgnA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		4 / 6 LEU A 511
VAL A  57
MET A  58
ILE A  36
 None
 1.04A 2hyyC-5kgnA:
undetectable		 2hyyC-5kgnA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 12 MET A 530
LEU A 340
PHE A 417
LEU A 519
MET A 522
 None
 1.36A 2pnjB-5kgnA:
undetectable		 2pnjB-5kgnA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 11 LEU A 462
VAL A  57
GLY A 449
ASP A 445
ILE A  34
 None
 1.38A 3bexE-5kgnA:
2.3
3bexF-5kgnA:
undetectable		 3bexE-5kgnA:
20.04
3bexF-5kgnA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 GLY A 429
ALA A 471
HIS A 430
HIS A 485
HIS A 468
 None
None
MN  A 604 (-3.4A)
MN  A 604 (-3.3A)
ZN  A 605 (-3.1A)
 1.46A 3boyA-5kgnA:
undetectable
3boyC-5kgnA:
undetectable		 3boyA-5kgnA:
13.11
3boyC-5kgnA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 HIS A 485
HIS A 468
GLY A 429
ALA A 471
HIS A 430
 MN  A 604 (-3.3A)
ZN  A 605 (-3.1A)
None
None
MN  A 604 (-3.4A)
 1.45A 3boyA-5kgnA:
undetectable
3boyB-5kgnA:
undetectable		 3boyA-5kgnA:
13.11
3boyB-5kgnA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA3001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 HIS A 485
HIS A 468
GLY A 429
ALA A 471
HIS A 430
 MN  A 604 (-3.3A)
ZN  A 605 (-3.1A)
None
None
MN  A 604 (-3.4A)
 1.45A 3boyB-5kgnA:
undetectable
3boyC-5kgnA:
undetectable		 3boyB-5kgnA:
13.11
3boyC-5kgnA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RXH_A_HSMA7_1
(CATIONIC TRYPSIN)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		4 / 5 ASP A 239
SER A 238
VAL A 246
GLY A 242
 None
 0.89A 3rxhA-5kgnA:
undetectable		 3rxhA-5kgnA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 12 GLY A  96
GLY A 532
GLN A 526
LEU A 511
ALA A 515
 None
 1.20A 3sxjA-5kgnA:
4.2		 3sxjA-5kgnA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 12 GLY A  96
GLY A 532
GLN A 526
LEU A 511
ALA A 515
 None
 1.21A 3sxjB-5kgnA:
3.7		 3sxjB-5kgnA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA1_A_08YA600_1
(CYTOCHROME P450 3A4)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 12 ASP A 178
ARG A 210
THR A 179
ALA A 205
ALA A 138
 GOL  A 602 (-2.9A)
GOL  A 602 (-3.1A)
None
None
None
 1.27A 3ua1A-5kgnA:
undetectable		 3ua1A-5kgnA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		4 / 7 VAL A 490
GLY A 469
VAL A  88
VAL A  76
 None
 0.79A 3ufnB-5kgnA:
undetectable		 3ufnB-5kgnA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		4 / 7 LEU A 140
ASP A 175
TYR A 283
HIS A 149
 None
 1.09A 4arcA-5kgnA:
undetectable		 4arcA-5kgnA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		4 / 6 LEU A 170
TYR A 169
LEU A 195
GLU A 240
 None
 1.19A 4f3tA-5kgnA:
undetectable		 4f3tA-5kgnA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_F_ACTF701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		4 / 4 PHE A 367
HIS A  90
GLY A  94
ILE A  93
 None
 1.41A 4k50E-5kgnA:
undetectable		 4k50E-5kgnA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_M_ACTM503_0
(RNA POLYMERASE
3D-POL)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		4 / 4 PHE A 367
HIS A  90
GLY A  94
ILE A  93
 None
 1.41A 4k50M-5kgnA:
undetectable		 4k50M-5kgnA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 12 HIS A 485
HIS A 430
GLY A 429
ASP A  37
GLY A  38
 MN  A 604 (-3.3A)
MN  A 604 (-3.4A)
None
ZN  A 605 (-2.0A)
None
 1.21A 4lxzA-5kgnA:
3.2		 4lxzA-5kgnA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 12 HIS A 485
HIS A 430
GLY A 429
ASP A  37
GLY A  38
 MN  A 604 (-3.3A)
MN  A 604 (-3.4A)
None
ZN  A 605 (-2.0A)
None
 1.19A 4lxzC-5kgnA:
3.2		 4lxzC-5kgnA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		3 / 3 ARG A 287
ASP A 217
ARG A 177
 GOL  A 602 (-3.6A)
None
GOL  A 602 (-3.3A)
 0.89A 4mx0A-5kgnA:
undetectable		 4mx0A-5kgnA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 12 ASP A 426
GLY A  38
GLY A 469
ALA A 484
GLY A  89
 MN  A 604 (-2.2A)
None
None
None
None
 0.89A 4n09B-5kgnA:
3.5		 4n09B-5kgnA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_1
(ADENOSINE KINASE)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 12 ASP A 426
GLY A  38
GLY A 469
ALA A 484
GLY A  89
 MN  A 604 (-2.2A)
None
None
None
None
 0.92A 4n09C-5kgnA:
4.9		 4n09C-5kgnA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 12 ASP A 426
GLY A  38
GLY A 469
ALA A 484
GLY A  89
 MN  A 604 (-2.2A)
None
None
None
None
 0.90A 4n09D-5kgnA:
3.3		 4n09D-5kgnA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		4 / 6 ARG A 450
ILE A 448
ILE A 407
ASP A 404
 None
 1.16A 4w5qA-5kgnA:
undetectable		 4w5qA-5kgnA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		4 / 4 GLY A  84
VAL A  76
PHE A 367
ILE A  93
 None
 0.87A 4xv2B-5kgnA:
undetectable		 4xv2B-5kgnA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_C_WJZC304_0
(BETA-LACTAMASE NDM-1)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		4 / 7 HIS A 468
GLY A  89
ASN A  85
HIS A 362
 ZN  A 605 (-3.1A)
None
None
None
 1.33A 5a5zC-5kgnA:
undetectable		 5a5zC-5kgnA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		4 / 8 ALA A 471
HIS A 430
HIS A 482
THR A 486
 None
MN  A 604 (-3.4A)
None
None
 1.11A 5db5A-5kgnA:
2.3
5db5B-5kgnA:
undetectable		 5db5A-5kgnA:
23.47
5db5B-5kgnA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 THR A 206
ALA A 226
GLY A 139
ALA A 213
HIS A 136
 None
 1.19A 5eeuF-5kgnA:
undetectable
5eeuG-5kgnA:
undetectable		 5eeuF-5kgnA:
11.00
5eeuG-5kgnA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 GLY A 139
ALA A 213
HIS A 136
THR A 206
ALA A 226
 None
 1.20A 5eeuO-5kgnA:
undetectable
5eeuP-5kgnA:
undetectable		 5eeuO-5kgnA:
11.00
5eeuP-5kgnA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 GLY A 139
ALA A 213
HIS A 136
THR A 206
ALA A 226
 None
 1.18A 5eeuQ-5kgnA:
undetectable
5eeuR-5kgnA:
undetectable		 5eeuQ-5kgnA:
11.00
5eeuR-5kgnA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 THR A 206
ALA A 226
GLY A 139
ALA A 213
HIS A 136
 None
 1.19A 5eevF-5kgnA:
undetectable
5eevG-5kgnA:
undetectable		 5eevF-5kgnA:
11.00
5eevG-5kgnA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 GLY A 139
ALA A 213
HIS A 136
THR A 206
ALA A 226
 None
 1.20A 5eevO-5kgnA:
undetectable
5eevP-5kgnA:
undetectable		 5eevO-5kgnA:
11.00
5eevP-5kgnA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 GLY A 139
ALA A 213
HIS A 136
THR A 206
ALA A 226
 None
 1.18A 5eevQ-5kgnA:
undetectable
5eevR-5kgnA:
undetectable		 5eevQ-5kgnA:
11.00
5eevR-5kgnA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 THR A 206
ALA A 226
GLY A 139
ALA A 213
HIS A 136
 None
 1.19A 5eewF-5kgnA:
undetectable
5eewG-5kgnA:
undetectable		 5eewF-5kgnA:
11.00
5eewG-5kgnA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 GLY A 139
ALA A 213
HIS A 136
THR A 206
ALA A 226
 None
 1.20A 5eewO-5kgnA:
undetectable
5eewP-5kgnA:
undetectable		 5eewO-5kgnA:
11.00
5eewP-5kgnA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 GLY A 139
ALA A 213
HIS A 136
THR A 206
ALA A 226
 None
 1.18A 5eewQ-5kgnA:
undetectable
5eewR-5kgnA:
undetectable		 5eewQ-5kgnA:
11.00
5eewR-5kgnA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 THR A 206
ALA A 226
GLY A 139
ALA A 213
HIS A 136
 None
 1.19A 5eexF-5kgnA:
undetectable
5eexG-5kgnA:
undetectable		 5eexF-5kgnA:
11.00
5eexG-5kgnA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 GLY A 139
ALA A 213
HIS A 136
THR A 206
ALA A 226
 None
 1.20A 5eexO-5kgnA:
undetectable
5eexP-5kgnA:
undetectable		 5eexO-5kgnA:
11.00
5eexP-5kgnA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 THR A 206
ALA A 226
GLY A 139
ALA A 213
HIS A 136
 None
 1.19A 5eeyF-5kgnA:
undetectable
5eeyG-5kgnA:
undetectable		 5eeyF-5kgnA:
11.00
5eeyG-5kgnA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 GLY A 139
ALA A 213
HIS A 136
THR A 206
ALA A 226
 None
 1.20A 5eeyO-5kgnA:
undetectable
5eeyP-5kgnA:
undetectable		 5eeyO-5kgnA:
11.00
5eeyP-5kgnA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 THR A 206
ALA A 226
GLY A 139
ALA A 213
HIS A 136
 None
 1.19A 5eezF-5kgnA:
undetectable
5eezG-5kgnA:
undetectable		 5eezF-5kgnA:
11.00
5eezG-5kgnA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 GLY A 139
ALA A 213
HIS A 136
THR A 206
ALA A 226
 None
 1.20A 5eezO-5kgnA:
undetectable
5eezP-5kgnA:
undetectable		 5eezO-5kgnA:
11.00
5eezP-5kgnA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 THR A 206
ALA A 226
GLY A 139
ALA A 213
HIS A 136
 None
 1.19A 5ef0F-5kgnA:
undetectable
5ef0G-5kgnA:
undetectable		 5ef0F-5kgnA:
11.00
5ef0G-5kgnA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 GLY A 139
ALA A 213
HIS A 136
THR A 206
ALA A 226
 None
 1.20A 5ef0O-5kgnA:
undetectable
5ef0P-5kgnA:
undetectable		 5ef0O-5kgnA:
11.00
5ef0P-5kgnA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 THR A 206
ALA A 226
GLY A 139
ALA A 213
HIS A 136
 None
 1.19A 5ef1F-5kgnA:
undetectable
5ef1G-5kgnA:
undetectable		 5ef1F-5kgnA:
11.00
5ef1G-5kgnA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 GLY A 139
ALA A 213
HIS A 136
THR A 206
ALA A 226
 None
 1.20A 5ef1O-5kgnA:
undetectable
5ef1P-5kgnA:
undetectable		 5ef1O-5kgnA:
11.00
5ef1P-5kgnA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 THR A 206
ALA A 226
GLY A 139
ALA A 213
HIS A 136
 None
 1.19A 5ef2F-5kgnA:
undetectable
5ef2G-5kgnA:
undetectable		 5ef2F-5kgnA:
11.00
5ef2G-5kgnA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 GLY A 139
ALA A 213
HIS A 136
THR A 206
ALA A 226
 None
 1.20A 5ef2O-5kgnA:
undetectable
5ef2P-5kgnA:
undetectable		 5ef2O-5kgnA:
11.00
5ef2P-5kgnA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 THR A 206
ALA A 226
GLY A 139
ALA A 213
HIS A 136
 None
 1.19A 5ef3F-5kgnA:
undetectable
5ef3G-5kgnA:
undetectable		 5ef3F-5kgnA:
11.00
5ef3G-5kgnA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 10 GLY A 139
ALA A 213
HIS A 136
THR A 206
ALA A 226
 None
 1.20A 5ef3O-5kgnA:
undetectable
5ef3P-5kgnA:
undetectable		 5ef3O-5kgnA:
11.00
5ef3P-5kgnA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 291
ALA A 213
PHE A 327
GLY A 317
GLY A 139
 None
 0.99A 5i71A-5kgnA:
undetectable		 5i71A-5kgnA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 291
PHE A 327
GLY A 317
GLY A 139
GLY A 296
 None
 1.10A 5i71A-5kgnA:
undetectable		 5i71A-5kgnA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		6 / 12 ILE A 291
ALA A 213
PHE A 327
GLY A 317
GLY A 139
GLY A 296
 None
 1.04A 5i73A-5kgnA:
undetectable		 5i73A-5kgnA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 291
ALA A 213
GLY A 317
GLY A 139
GLY A 296
 None
 1.08A 5i75A-5kgnA:
undetectable		 5i75A-5kgnA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 12 ILE A 291
ALA A 213
GLY A 317
PHE A 280
GLY A 139
 None
 1.20A 5i75A-5kgnA:
undetectable		 5i75A-5kgnA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		4 / 7 LEU A 170
TYR A 169
LEU A 195
GLU A 240
 None
 1.06A 5t7bA-5kgnA:
undetectable		 5t7bA-5kgnA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 12 LEU A 313
ILE A 278
ALA A 138
ALA A 226
GLY A 233
 None
 1.14A 5veuA-5kgnA:
undetectable		 5veuA-5kgnA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE
(Caenorhabditis
elegans) 		5 / 12 GLU A 472
VAL A  41
PRO A 491
THR A 465
HIS A  90
 None
 1.44A 5xioB-5kgnA:
2.7		 5xioB-5kgnA:
21.59