SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kgo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 5kgo FLAGELLAR BRAKE
PROTEIN YCGR
(Klebsiella
pneumoniae) 		5 / 11 ILE D  29
PHE D  66
ILE D  58
PRO D  59
ILE D  52
 None
 1.08A 1dyrA-5kgoD:
undetectable		 1dyrA-5kgoD:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 5kgo FLAGELLAR BRAKE
PROTEIN YCGR
(Klebsiella
pneumoniae) 		3 / 3 GLU D  28
HIS D  69
ASP D 140
 None
C2E  D 301 (-3.6A)
C2E  D 302 (-3.7A)
 0.73A 1i9gA-5kgoD:
undetectable		 1i9gA-5kgoD:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 5kgo FLAGELLAR BRAKE
PROTEIN YCGR
(Klebsiella
pneumoniae) 		4 / 7 LEU D 148
ALA D 167
GLY D 126
PHE D 136
 None
 0.91A 2wq5A-5kgoD:
undetectable		 2wq5A-5kgoD:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 5kgo FLAGELLAR BRAKE
PROTEIN YCGR
(Klebsiella
pneumoniae) 		5 / 12 GLY D  73
GLN D 107
VAL D 105
ARG D 110
ILE D  18
 C2E  D 301 (-3.3A)
C2E  D 301 ( 4.1A)
None
None
None
 1.14A 3h52B-5kgoD:
undetectable		 3h52B-5kgoD:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5kgo FLAGELLAR BRAKE
PROTEIN YCGR
(Klebsiella
pneumoniae) 		3 / 3 ARG D 108
LYS D   5
ARG D 110
 C2E  D 302 ( 2.9A)
None
None
 1.37A 3w1wA-5kgoD:
undetectable
3w1wB-5kgoD:
undetectable		 3w1wA-5kgoD:
18.53
3w1wB-5kgoD:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5kgo FLAGELLAR BRAKE
PROTEIN YCGR
(Klebsiella
pneumoniae) 		3 / 3 ARG D 110
ARG D 108
LYS D   5
 None
C2E  D 302 ( 2.9A)
None
 1.44A 3w1wA-5kgoD:
undetectable
3w1wB-5kgoD:
undetectable		 3w1wA-5kgoD:
18.53
3w1wB-5kgoD:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5kgo FLAGELLAR BRAKE
PROTEIN YCGR
(Klebsiella
pneumoniae) 		3 / 3 GLU D  28
HIS D  69
ASP D 140
 None
C2E  D 301 (-3.6A)
C2E  D 302 (-3.7A)
 0.68A 5c0oG-5kgoD:
undetectable		 5c0oG-5kgoD:
21.17