SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kh0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		3 / 3 ASP A 168
ARG A 356
ILE A 171
 None
 0.85A 1a4gB-5kh0A:
undetectable		 1a4gB-5kh0A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R9O_A_FLPA501_1
(CYTOCHROME P450 2C9)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		5 / 12 ARG A  16
VAL A  19
ILE A 119
LEU A  93
ASP A  96
 None
 1.09A 1r9oA-5kh0A:
undetectable		 1r9oA-5kh0A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T85_A_CAMA422_0
(CYTOCHROME P450-CAM)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 7 THR A 320
LEU A 324
VAL A 292
VAL A 379
 None
 1.07A 1t85A-5kh0A:
undetectable		 1t85A-5kh0A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 4 ASP A 179
LEU A 238
LEU A 177
LEU A 183
 None
 1.17A 1u18A-5kh0A:
undetectable		 1u18A-5kh0A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRC_A_CAMA420_0
(CYTOCHROME P450-CAM)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 7 THR A 320
LEU A 324
VAL A 292
VAL A 379
 None
 0.99A 1yrcA-5kh0A:
undetectable		 1yrcA-5kh0A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRD_A_CAMA420_0
(CYTOCHROME P450-CAM)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 7 THR A 320
LEU A 324
VAL A 292
VAL A 379
 None
 1.02A 1yrdA-5kh0A:
undetectable		 1yrdA-5kh0A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 8 VAL A  19
GLY A  20
VAL A 146
ILE A 121
 None
 0.72A 2a1mB-5kh0A:
undetectable		 2a1mB-5kh0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		5 / 12 LEU A  53
PHE A 118
GLY A  91
CYH A  90
LEU A  61
 None
 1.08A 2bxeB-5kh0A:
undetectable		 2bxeB-5kh0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 6 THR A 320
LEU A 324
VAL A 292
VAL A 379
 None
 0.98A 2feuA-5kh0A:
undetectable		 2feuA-5kh0A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_B_CAMB1421_0
(CYTOCHROME P450-CAM)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 7 THR A 320
LEU A 324
VAL A 292
VAL A 379
 None
 0.98A 2feuB-5kh0A:
undetectable		 2feuB-5kh0A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		3 / 3 HIS A 348
MET A 373
MET A 359
 None
 1.28A 2vj1A-5kh0A:
undetectable		 2vj1A-5kh0A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 7 ILE A 164
LEU A 165
VAL A  56
GLY A 158
 None
 0.75A 2wd9A-5kh0A:
5.2		 2wd9A-5kh0A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 8 ILE A 164
LEU A 165
VAL A  56
GLY A 158
 None
 0.76A 2wd9B-5kh0A:
4.6		 2wd9B-5kh0A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_C_GLYC73_0
(NONSTRUCTURAL
PROTEIN 1)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 4 ASP A 179
ASP A 176
SER A 175
ARG A 213
 None
 1.47A 2z0aC-5kh0A:
0.0		 2z0aC-5kh0A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 6 THR A 320
LEU A 324
VAL A 292
VAL A 379
 None
 1.04A 2zuhA-5kh0A:
undetectable		 2zuhA-5kh0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUI_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 6 THR A 320
LEU A 324
VAL A 292
VAL A 379
 None
 1.03A 2zuiA-5kh0A:
undetectable		 2zuiA-5kh0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWT_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 7 THR A 320
LEU A 324
VAL A 292
VAL A 379
 None
 1.00A 2zwtA-5kh0A:
undetectable		 2zwtA-5kh0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWU_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 7 THR A 320
LEU A 324
VAL A 292
VAL A 379
 None
 1.00A 2zwuA-5kh0A:
undetectable		 2zwuA-5kh0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 7 THR A 320
LEU A 324
VAL A 292
VAL A 379
 None
 0.97A 3fwfA-5kh0A:
undetectable		 3fwfA-5kh0A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 7 THR A 320
LEU A 324
VAL A 292
VAL A 379
 None
 0.97A 3fwfB-5kh0A:
undetectable		 3fwfB-5kh0A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWI_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 7 THR A 320
LEU A 324
VAL A 292
VAL A 379
 None
 1.04A 3fwiA-5kh0A:
undetectable		 3fwiA-5kh0A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWJ_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 7 THR A 320
LEU A 324
VAL A 292
VAL A 379
 None
 1.00A 3fwjA-5kh0A:
undetectable		 3fwjA-5kh0A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L63_A_CAMA440_0
(CAMPHOR
5-MONOOXYGENASE)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 7 THR A 320
LEU A 324
VAL A 292
VAL A 379
 None
 0.98A 3l63A-5kh0A:
undetectable		 3l63A-5kh0A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		5 / 10 ILE A 164
VAL A 141
PHE A 118
THR A  14
ILE A  94
 None
 1.31A 3um5A-5kh0A:
2.3		 3um5A-5kh0A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		5 / 10 ILE A 164
VAL A 141
PHE A 118
THR A  14
ILE A  94
 None
 1.32A 3um5B-5kh0A:
undetectable		 3um5B-5kh0A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		5 / 12 GLY A 321
ASP A 288
VAL A 292
ASN A 318
LEU A 326
 None
 1.19A 3v8vA-5kh0A:
3.3		 3v8vA-5kh0A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		5 / 11 GLY A 321
ASP A 288
VAL A 292
ASN A 318
LEU A 326
 None
 1.27A 3v8vB-5kh0A:
undetectable		 3v8vB-5kh0A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 7 THR A 320
LEU A 324
VAL A 292
VAL A 379
 None
 0.98A 3wrhA-5kh0A:
undetectable		 3wrhA-5kh0A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 7 THR A 320
LEU A 324
VAL A 292
VAL A 379
 None
 0.99A 3wrjA-5kh0A:
undetectable		 3wrjA-5kh0A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 7 THR A 320
LEU A 324
VAL A 292
VAL A 379
 None
 0.97A 3wrlA-5kh0A:
undetectable		 3wrlA-5kh0A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 7 THR A 320
LEU A 324
VAL A 292
VAL A 379
 None
 0.98A 3wrlE-5kh0A:
undetectable		 3wrlE-5kh0A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 7 THR A 320
LEU A 324
VAL A 292
VAL A 379
 None
 0.97A 3wrmA-5kh0A:
undetectable		 3wrmA-5kh0A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_F_CAMF503_0
(CAMPHOR
5-MONOOXYGENASE)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 7 THR A 320
LEU A 324
VAL A 292
VAL A 379
 None
 1.01A 3wrmF-5kh0A:
undetectable		 3wrmF-5kh0A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 8 ILE A 294
ILE A 347
SER A 243
GLY A 377
 None
 0.78A 4acaC-5kh0A:
15.7		 4acaC-5kh0A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 8 ILE A 294
ILE A 347
SER A 243
GLY A 377
 None
 0.81A 4acbC-5kh0A:
15.8		 4acbC-5kh0A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 4 ILE A 380
SER A 381
ASP A 242
ASP A 191
 None
 1.42A 4krhB-5kh0A:
4.3		 4krhB-5kh0A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 7 ASN A 131
GLU A 130
GLU A 133
GLU A 135
 None
 1.34A 4mj8C-5kh0A:
undetectable		 4mj8C-5kh0A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		5 / 12 ASP A 176
ALA A 206
SER A 175
GLY A 210
THR A 260
 None
 1.32A 4mm4A-5kh0A:
undetectable		 4mm4A-5kh0A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		5 / 12 LEU A  53
PHE A 118
GLY A  91
CYH A  90
LEU A  61
 None
 1.17A 4ot2A-5kh0A:
undetectable		 4ot2A-5kh0A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		5 / 12 LEU A  93
ILE A 143
ILE A 132
ILE A  98
ILE A 119
 None
 0.86A 4q1yB-5kh0A:
undetectable		 4q1yB-5kh0A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UYM_B_VORB590_1
(14-ALPHA STEROL
DEMETHYLASE)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 7 ALA A 120
ILE A  13
LEU A  28
PHE A  24
 None
 0.81A 4uymB-5kh0A:
undetectable		 4uymB-5kh0A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 5 ARG A 314
ARG A 309
GLY A 308
GLU A 296
 None
None
None
SF4  A 401 (-3.9A)
 1.25A 4z3oA-5kh0A:
3.8
4z3oB-5kh0A:
2.4		 4z3oA-5kh0A:
20.58
4z3oB-5kh0A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_2
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 6 ILE A  98
PRO A  99
ILE A  94
VAL A  19
 None
 0.86A 4zj8A-5kh0A:
2.1		 4zj8A-5kh0A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		3 / 3 ARG A  16
TYR A 136
GLU A 103
 None
 0.60A 4zzbE-5kh0A:
undetectable		 4zzbE-5kh0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 5 ARG A 309
GLY A 308
GLU A 296
ARG A 314
 None
None
SF4  A 401 (-3.9A)
None
 1.16A 5cdqR-5kh0A:
undetectable
5cdqS-5kh0A:
2.3
5cdqT-5kh0A:
undetectable		 5cdqR-5kh0A:
24.95
5cdqS-5kh0A:
18.89
5cdqT-5kh0A:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		3 / 3 MET A 354
HIS A 348
GLY A 331
 None
 0.83A 5gwzB-5kh0A:
undetectable		 5gwzB-5kh0A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		3 / 3 ALA A 282
ASN A 285
LEU A 286
 None
 0.37A 5i1oC-5kh0A:
undetectable		 5i1oC-5kh0A:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		5 / 10 ALA A  27
ILE A  11
ILE A  92
PHE A  24
ALA A 148
 None
 1.22A 5nukA-5kh0A:
undetectable		 5nukA-5kh0A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WK9_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 7 THR A 320
LEU A 324
VAL A 292
VAL A 379
 None
 0.96A 5wk9A-5kh0A:
undetectable		 5wk9A-5kh0A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		3 / 3 ARG A 213
ARG A 268
ARG A 237
 None
 1.10A 6bplA-5kh0A:
undetectable
6bplB-5kh0A:
2.5		 6bplA-5kh0A:
14.29
6bplB-5kh0A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G502_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 8 ILE A 200
GLN A 203
VAL A 204
PRO A 189
 None
 1.02A 6cduG-5kh0A:
undetectable
6cduH-5kh0A:
undetectable		 6cduG-5kh0A:
22.30
6cduH-5kh0A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5kh0 SMALL GTP-BINDING
PROTEIN
(Thermosipho
melanesiensis) 		4 / 7 ASP A 333
ARG A   8
TYR A  10
GLU A  52
 None
 1.14A 6mn5E-5kh0A:
undetectable		 6mn5E-5kh0A:
11.29