SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kh1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_B_HISB450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5kh1 INVASION PLASMID
ANTIGEN
(Shigella
flexneri) 		5 / 12 THR A 556
GLU A 555
LEU A 521
TYR A 525
GLY A 549
 None
 1.21A 1httB-5kh1A:
undetectable		 1httB-5kh1A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5kh1 INVASION PLASMID
ANTIGEN
(Shigella
flexneri) 		5 / 12 THR A 556
GLU A 555
LEU A 521
TYR A 525
GLY A 549
 None
 1.20A 1httC-5kh1A:
undetectable		 1httC-5kh1A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 5kh1 INVASION PLASMID
ANTIGEN
(Shigella
flexneri) 		5 / 12 THR A 556
GLU A 555
LEU A 521
TYR A 525
GLY A 549
 None
 1.28A 1httD-5kh1A:
undetectable		 1httD-5kh1A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 5kh1 INVASION PLASMID
ANTIGEN
(Shigella
flexneri) 		4 / 8 LEU A 381
ASP A 377
ARG A 425
GLU A 436
 None
 1.05A 2j2pA-5kh1A:
undetectable
2j2pB-5kh1A:
undetectable		 2j2pA-5kh1A:
14.63
2j2pB-5kh1A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 5kh1 INVASION PLASMID
ANTIGEN
(Shigella
flexneri) 		4 / 5 PRO A 118
SER A 100
LEU A 141
SER A 140
 None
 1.35A 3iluH-5kh1A:
undetectable		 3iluH-5kh1A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 5kh1 INVASION PLASMID
ANTIGEN
(Shigella
flexneri) 		4 / 5 PRO A 158
SER A 140
LEU A 181
SER A 180
 None
 1.17A 3iluH-5kh1A:
undetectable		 3iluH-5kh1A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 5kh1 INVASION PLASMID
ANTIGEN
(Shigella
flexneri) 		4 / 8 SER A 332
ASP A 294
LEU A 292
ASP A 282
 None
 1.22A 3n2oC-5kh1A:
undetectable
3n2oD-5kh1A:
undetectable		 3n2oC-5kh1A:
22.21
3n2oD-5kh1A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 5kh1 INVASION PLASMID
ANTIGEN
(Shigella
flexneri) 		4 / 8 SER A 332
ASP A 294
LEU A 292
ASP A 282
 None
 1.23A 3n2oC-5kh1A:
undetectable
3n2oD-5kh1A:
undetectable		 3n2oC-5kh1A:
22.21
3n2oD-5kh1A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 5kh1 INVASION PLASMID
ANTIGEN
(Shigella
flexneri) 		4 / 8 SER A 336
ASP A 294
LEU A 292
ASP A 282
 None
 1.02A 3n2oC-5kh1A:
undetectable
3n2oD-5kh1A:
undetectable		 3n2oC-5kh1A:
22.21
3n2oD-5kh1A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		 5kh1 INVASION PLASMID
ANTIGEN
(Shigella
flexneri) 		4 / 8 PHE A 400
PRO A 497
GLY A 411
PHE A 492
 None
 1.09A 3tzfB-5kh1A:
undetectable		 3tzfB-5kh1A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_B_C2FB300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5kh1 INVASION PLASMID
ANTIGEN
(Shigella
flexneri) 		5 / 12 ASP A 227
ILE A 231
LEU A 254
SER A 246
GLN A 275
 None
 1.48A 4djfB-5kh1A:
undetectable		 4djfB-5kh1A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5kh1 INVASION PLASMID
ANTIGEN
(Shigella
flexneri) 		5 / 12 ILE A 204
ALA A 206
TRP A 205
LEU A 177
PRO A 178
 None
 1.00A 4p3qA-5kh1A:
undetectable		 4p3qA-5kh1A:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 5kh1 INVASION PLASMID
ANTIGEN
(Shigella
flexneri) 		5 / 12 ILE A 184
ALA A 206
LEU A 197
LEU A 241
LEU A 221
 None
 1.18A 4qzuC-5kh1A:
undetectable		 4qzuC-5kh1A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 5kh1 INVASION PLASMID
ANTIGEN
(Shigella
flexneri) 		5 / 10 LEU A 177
LEU A 164
SER A 153
LEU A 154
LEU A 161
 None
 1.21A 4yiaA-5kh1A:
undetectable		 4yiaA-5kh1A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5kh1 INVASION PLASMID
ANTIGEN
(Shigella
flexneri) 		5 / 12 THR A 556
GLU A 555
LEU A 521
TYR A 525
GLY A 549
 None
 1.22A 5e3iA-5kh1A:
undetectable		 5e3iA-5kh1A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5kh1 INVASION PLASMID
ANTIGEN
(Shigella
flexneri) 		5 / 12 ILE A 204
ALA A 206
TRP A 205
LEU A 177
PRO A 178
 None
 0.91A 5eajB-5kh1A:
undetectable		 5eajB-5kh1A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5kh1 INVASION PLASMID
ANTIGEN
(Shigella
flexneri) 		5 / 9 LEU A 221
LEU A 197
ILE A 184
PRO A 178
LEU A 177
 None
 1.49A 5g48B-5kh1A:
undetectable		 5g48B-5kh1A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5kh1 INVASION PLASMID
ANTIGEN
(Shigella
flexneri) 		5 / 12 HIS A 499
GLN A 558
LEU A 569
GLY A 411
LEU A 408
 None
 1.06A 5jw1A-5kh1A:
2.0		 5jw1A-5kh1A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 5kh1 INVASION PLASMID
ANTIGEN
(Shigella
flexneri) 		4 / 4 ASN A 252
LEU A 254
SER A 250
LEU A 262
 None
 1.39A 5kb5A-5kh1A:
undetectable		 5kb5A-5kh1A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 5kh1 INVASION PLASMID
ANTIGEN
(Shigella
flexneri) 		3 / 3 ILE A  81
THR A  62
PRO A  78
 None
 0.60A 6ncsA-5kh1A:
undetectable		 6ncsA-5kh1A:
21.68