SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kh5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 5kh5 ISOPRENYL
TRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A 109
ALA A 129
THR A 115
LEU A 145
PHE A 123
 None
 1.20A 1og5B-5kh5A:
undetectable		 1og5B-5kh5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L63_A_CAMA440_0
(CAMPHOR
5-MONOOXYGENASE)		 5kh5 ISOPRENYL
TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 7 PHE A 143
THR A  56
LEU A 102
VAL A  99
 None
 0.91A 3l63A-5kh5A:
undetectable		 3l63A-5kh5A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6V_A_SAMA465_0
(RRNA METHYLASE)		 5kh5 ISOPRENYL
TRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  71
GLY A  29
GLY A  31
VAL A  69
LEU A 145
 None
 1.09A 3m6vA-5kh5A:
undetectable		 3m6vA-5kh5A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 5kh5 ISOPRENYL
TRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  71
GLY A  29
GLY A  31
VAL A  69
LEU A 145
 None
 1.06A 3m6wA-5kh5A:
undetectable		 3m6wA-5kh5A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5kh5 ISOPRENYL
TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 7 PHE A 143
THR A  56
LEU A 102
VAL A  99
 None
 0.92A 3wrhA-5kh5A:
undetectable		 3wrhA-5kh5A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5kh5 ISOPRENYL
TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 7 PHE A 143
THR A  56
LEU A 102
VAL A  99
 None
 0.92A 3wrlA-5kh5A:
undetectable		 3wrlA-5kh5A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5kh5 ISOPRENYL
TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 7 PHE A 143
THR A  56
LEU A 102
VAL A  99
 None
 0.91A 3wrmA-5kh5A:
undetectable		 3wrmA-5kh5A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5kh5 ISOPRENYL
TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 4 PHE A 143
VAL A  69
ALA A 144
PHE A 210
 None
 1.46A 4f3tA-5kh5A:
undetectable		 4f3tA-5kh5A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_A_LURA201_1
(TRANSTHYRETIN)		 5kh5 ISOPRENYL
TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 4 LYS A  65
LEU A 192
ALA A  21
VAL A  19
 None
 1.38A 4ik6A-5kh5A:
undetectable		 4ik6A-5kh5A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 5kh5 ISOPRENYL
TRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 ALA A  71
ILE A  87
LEU A 118
PRO A 119
LEU A 126
 None
 1.08A 4m2xE-5kh5A:
undetectable		 4m2xE-5kh5A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 5kh5 ISOPRENYL
TRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 LEU A 141
ALA A  59
ILE A  23
VAL A  69
ILE A  67
 None
 0.75A 4q1yB-5kh5A:
undetectable		 4q1yB-5kh5A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 5kh5 ISOPRENYL
TRANSFERASE
(Streptococcus
pneumoniae) 		5 / 12 ARG A 193
ILE A 179
GLN A 155
ALA A 156
ILE A 160
 None
 1.07A 4uroC-5kh5A:
undetectable		 4uroC-5kh5A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5kh5 ISOPRENYL
TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 4 PHE A 143
VAL A  69
ALA A 144
PHE A 210
 None
 1.44A 4w5qA-5kh5A:
2.5		 4w5qA-5kh5A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5kh5 ISOPRENYL
TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 4 PHE A 143
VAL A  69
ALA A 144
PHE A 210
 None
 1.47A 4w5rA-5kh5A:
2.1		 4w5rA-5kh5A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5kh5 ISOPRENYL
TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 4 PHE A 143
VAL A  69
ALA A 144
PHE A 210
 None
 1.45A 4w5tA-5kh5A:
2.3		 4w5tA-5kh5A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5kh5 ISOPRENYL
TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 4 PHE A 143
VAL A  69
ALA A 144
PHE A 210
 None
 1.41A 4z4gA-5kh5A:
3.6		 4z4gA-5kh5A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5kh5 ISOPRENYL
TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 4 PHE A 143
VAL A  69
ALA A 144
PHE A 210
 None
 1.42A 5ki6A-5kh5A:
3.5		 5ki6A-5kh5A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 5kh5 ISOPRENYL
TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 7 PHE A  94
GLN A  53
MET A  27
THR A  56
 None
 1.21A 5u6mA-5kh5A:
3.5		 5u6mA-5kh5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_B_SALB503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 5kh5 ISOPRENYL
TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 7 PHE A  94
GLN A  53
MET A  27
THR A  56
 None
 1.19A 5u6mB-5kh5A:
4.1		 5u6mB-5kh5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_A_SALA505_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 5kh5 ISOPRENYL
TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 8 PHE A  94
GLN A  53
MET A  27
THR A  56
 None
 1.23A 5u6nA-5kh5A:
undetectable		 5u6nA-5kh5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_B_SALB504_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 5kh5 ISOPRENYL
TRANSFERASE
(Streptococcus
pneumoniae) 		4 / 6 PHE A  94
GLN A  53
MET A  27
THR A  56
 None
 1.25A 5u6nB-5kh5A:
4.3		 5u6nB-5kh5A:
21.78