SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kh6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A9K_A_TYLA2200_1 (CREB-BINDING PROTEIN)	5kh6	HISTONE-LYSINE N-METHYLTRANSFERASE SETDB1 (Homo sapiens)	4 / 6	VAL A 346 LEU A 395 ILE A 354 VAL A 370	None	0.93A	4a9kA-5kh6A: undetectable	4a9kA-5kh6A: 20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NOO_C_D16C402_1 (THYMIDYLATE SYNTHASE)	5kh6	HISTONE-LYSINE N-METHYLTRANSFERASE SETDB1 (Homo sapiens)	4 / 6	TYR A 389 ASP A 299 GLY A 300 TYR A 277	6SU A 513 (-4.9A) None 6SU A 513 ( 3.7A) None	1.03A	5nooC-5kh6A: undetectable	5nooC-5kh6A: 21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AG0_A_ACRA608_0 (ALPHA-AMYLASE)	5kh6	HISTONE-LYSINE N-METHYLTRANSFERASE SETDB1 (Homo sapiens)	4 / 6	GLY A 227 THR A 223 GLN A 195 TYR A 230	None	1.19A	6ag0A-5kh6A: undetectable	6ag0A-5kh6A: 16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AG0_C_ACRC606_0 (ALPHA-AMYLASE)	5kh6	HISTONE-LYSINE N-METHYLTRANSFERASE SETDB1 (Homo sapiens)	4 / 6	GLY A 227 THR A 223 GLN A 195 TYR A 230	None	1.18A	6ag0C-5kh6A: undetectable	6ag0C-5kh6A: 16.08

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4A9K_A_TYLA2200_1","CREB-BINDING PROTEIN","5kh6","HISTONE-LYSINE N-METHYLTRANSFERASE SETDB1","Homo sapiens",4,"VAL A 346;LEU A 395;ILE A 354;VAL A 370","None","0.93A","4a9kA-5kh6A:undetectable","4a9kA-5kh6A:20.29"],["5NOO_C_D16C402_1","THYMIDYLATE SYNTHASE","5kh6","HISTONE-LYSINE N-METHYLTRANSFERASE SETDB1","Homo sapiens",4,"TYR A 389;ASP A 299;GLY A 300;TYR A 277","6SU A 513 (-4.9A);None;6SU A 513 ( 3.7A);None","1.03A","5nooC-5kh6A:undetectable","5nooC-5kh6A:21.90"],["6AG0_A_ACRA608_0","ALPHA-AMYLASE","5kh6","HISTONE-LYSINE N-METHYLTRANSFERASE SETDB1","Homo sapiens",4,"GLY A 227;THR A 223;GLN A 195;TYR A 230","None","1.19A","6ag0A-5kh6A:undetectable","6ag0A-5kh6A:16.08"],["6AG0_C_ACRC606_0","ALPHA-AMYLASE","5kh6","HISTONE-LYSINE N-METHYLTRANSFERASE SETDB1","Homo sapiens",4,"GLY A 227;THR A 223;GLN A 195;TYR A 230","None","1.18A","6ag0C-5kh6A:undetectable","6ag0C-5kh6A:16.08"]]