SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kha'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE
(Acinetobacter
baumannii) 		4 / 7 ASN A 535
TYR A 477
ARG A 529
ARG A 511
 None
 1.02A 1f9gA-5khaA:
undetectable		 1f9gA-5khaA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE
(Acinetobacter
baumannii) 		4 / 6 SER A  12
VAL A 204
GLY A 205
GLU A 262
 None
 0.99A 1fduD-5khaA:
3.0		 1fduD-5khaA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE
(Acinetobacter
baumannii) 		5 / 10 GLN A 158
HIS A 112
ASP A 149
VAL A 167
VAL A 164
 None
 1.27A 3fhjB-5khaA:
2.4		 3fhjB-5khaA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE
(Acinetobacter
baumannii) 		3 / 3 ASN A 110
MET A 100
PHE A  84
 None
 1.15A 3g4lD-5khaA:
undetectable		 3g4lD-5khaA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE
(Acinetobacter
baumannii) 		5 / 12 ASN A 433
MET A 334
VAL A 301
LEU A 297
ILE A 446
 None
 1.27A 3mnoA-5khaA:
undetectable		 3mnoA-5khaA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE
(Acinetobacter
baumannii) 		5 / 12 ASN A 433
MET A 334
VAL A 301
LEU A 297
ILE A 446
 None
 1.27A 3mnpA-5khaA:
undetectable		 3mnpA-5khaA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE
(Acinetobacter
baumannii) 		5 / 9 TYR A 237
ILE A 238
VAL A 201
ILE A  40
ILE A  41
 None
 1.23A 3p4wB-5khaA:
undetectable		 3p4wB-5khaA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE
(Acinetobacter
baumannii) 		5 / 10 TYR A 237
ILE A 238
VAL A 201
ILE A  40
ILE A  41
 None
 1.23A 3p4wE-5khaA:
undetectable		 3p4wE-5khaA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S68_A_SAMA228_0
(CATECHOL
O-METHYLTRANSFERASE)		 5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE
(Acinetobacter
baumannii) 		5 / 10 GLU A 148
GLU A 122
SER A 172
GLN A 203
ASP A 149
 None
 1.49A 3s68A-5khaA:
2.9		 3s68A-5khaA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA803_1
(CATALASE-PEROXIDASE)		 5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE
(Acinetobacter
baumannii) 		4 / 4 ASP A 292
THR A 296
VAL A 420
SER A 392
 None
 1.37A 3wxoA-5khaA:
undetectable		 3wxoA-5khaA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE
(Acinetobacter
baumannii) 		4 / 6 GLU A 498
ASP A 505
ASN A  60
ARG A  64
 None
 1.41A 4ntxA-5khaA:
2.4
4ntxC-5khaA:
undetectable		 4ntxA-5khaA:
22.18
4ntxC-5khaA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_C_PARC500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE
(Acinetobacter
baumannii) 		5 / 10 SER A 231
PHE A 232
SER A 173
TYR A 200
GLY A 178
 None
None
CL  A 602 (-3.1A)
None
None
 1.45A 4qb9C-5khaA:
undetectable		 4qb9C-5khaA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE
(Acinetobacter
baumannii) 		5 / 12 GLY A 266
GLN A 265
ALA A 229
GLY A 214
PHE A 232
 None
 1.23A 4r29A-5khaA:
undetectable		 4r29A-5khaA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE
(Acinetobacter
baumannii) 		5 / 12 GLY A 266
GLN A 265
ALA A 229
GLY A 214
TYR A 237
 None
 1.23A 4r29A-5khaA:
undetectable		 4r29A-5khaA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE
(Acinetobacter
baumannii) 		5 / 12 ASN A  21
ALA A  52
ILE A  15
ASN A 202
GLY A 205
 None
EDO  A 601 (-3.4A)
None
None
None
 1.25A 4r38B-5khaA:
undetectable		 4r38B-5khaA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE
(Acinetobacter
baumannii) 		5 / 12 ALA A  52
GLY A  83
PHE A 126
GLN A  87
LEU A  61
 EDO  A 601 (-3.4A)
None
None
None
None
 1.24A 4uilH-5khaA:
undetectable
4uilL-5khaA:
undetectable		 4uilH-5khaA:
19.01
4uilL-5khaA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_B_SALB801_1
(PROTEIN POLYBROMO-1)		 5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE
(Acinetobacter
baumannii) 		4 / 5 LEU A  57
TYR A 125
ALA A  52
ILE A  48
 None
EDO  A 601 ( 4.7A)
EDO  A 601 (-3.4A)
None
 1.05A 4y03B-5khaA:
undetectable		 4y03B-5khaA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE
(Acinetobacter
baumannii) 		4 / 7 HIS A 344
ILE A 346
VAL A 347
ARG A 375
 None
 0.89A 5kkzC-5khaA:
undetectable
5kkzE-5khaA:
undetectable		 5kkzC-5khaA:
16.41
5kkzE-5khaA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE
(Acinetobacter
baumannii) 		4 / 7 HIS A 344
ILE A 346
VAL A 347
ARG A 375
 None
 0.86A 5kkzK-5khaA:
undetectable
5kkzQ-5khaA:
undetectable		 5kkzK-5khaA:
22.44
5kkzQ-5khaA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE
(Acinetobacter
baumannii) 		4 / 7 HIS A 344
ILE A 346
VAL A 347
ARG A 375
 None
 0.95A 5kkzM-5khaA:
undetectable
5kkzO-5khaA:
undetectable		 5kkzM-5khaA:
16.41
5kkzO-5khaA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE
(Acinetobacter
baumannii) 		5 / 12 GLN A 193
LEU A 190
ILE A 198
VAL A 164
ASP A 149
 None
 1.21A 5vlmG-5khaA:
2.6		 5vlmG-5khaA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE
(Acinetobacter
baumannii) 		5 / 12 VAL A  75
ILE A  78
SER A  46
VAL A  81
ILE A  40
 None
 1.36A 6gsdA-5khaA:
undetectable		 6gsdA-5khaA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE
(Acinetobacter
baumannii) 		3 / 3 ASN A  21
PRO A  13
GLN A 207
 None
 0.95A 6jnhA-5khaA:
4.6		 6jnhA-5khaA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE
(Acinetobacter
baumannii) 		3 / 3 ASN A  21
PRO A  13
GLN A 207
 None
 0.95A 6jogA-5khaA:
6.0		 6jogA-5khaA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5kha GLUTAMINE-DEPENDENT
NAD+ SYNTHETASE
(Acinetobacter
baumannii) 		3 / 3 THR A 155
GLU A  44
ASN A 113
 None
 0.92A 6nj9K-5khaA:
undetectable		 6nj9K-5khaA:
22.18