SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5khl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 5khl HEMIN ABC
TRANSPORTER,
PERIPLASMIC
HEMIN-BINDING
PROTEIN HUTB
(Vibrio
cholerae) 		5 / 12 MET B  88
LEU B  82
LEU B  74
ILE B 126
PRO B  61
 None
 1.41A 1hrkB-5khlB:
undetectable		 1hrkB-5khlB:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 5khl HEMIN ABC
TRANSPORTER,
PERIPLASMIC
HEMIN-BINDING
PROTEIN HUTB
(Vibrio
cholerae) 		3 / 3 GLU B 165
SER B 217
VAL B 216
 None
 0.81A 3eeoA-5khlB:
2.4		 3eeoA-5khlB:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 5khl HEMIN ABC
TRANSPORTER,
PERIPLASMIC
HEMIN-BINDING
PROTEIN HUTB
(Vibrio
cholerae) 		5 / 12 GLY B 243
ALA B 242
ASP B 212
ILE B 207
VAL B 214
 None
 0.83A 3el4A-5khlB:
undetectable		 3el4A-5khlB:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 5khl HEMIN ABC
TRANSPORTER,
PERIPLASMIC
HEMIN-BINDING
PROTEIN HUTB
(Vibrio
cholerae) 		5 / 12 GLY B 243
ALA B 242
ASP B 212
ILE B 207
VAL B 214
 None
 0.93A 3el5B-5khlB:
undetectable		 3el5B-5khlB:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5khl HEMIN ABC
TRANSPORTER,
PERIPLASMIC
HEMIN-BINDING
PROTEIN HUTB
(Vibrio
cholerae) 		5 / 12 HIS B  81
LEU B  45
ILE B  83
GLY B  29
ALA B  28
 None
 1.18A 3n8xA-5khlB:
undetectable		 3n8xA-5khlB:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 5khl HEMIN ABC
TRANSPORTER,
PERIPLASMIC
HEMIN-BINDING
PROTEIN HUTB
(Vibrio
cholerae) 		4 / 7 GLY B 243
ALA B 242
ASP B 212
ILE B 207
 None
 0.78A 3t3cA-5khlB:
undetectable		 3t3cA-5khlB:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5khl HEMIN ABC
TRANSPORTER,
PERIPLASMIC
HEMIN-BINDING
PROTEIN HUTB
(Vibrio
cholerae) 		5 / 12 MET B  88
LEU B  82
LEU B  74
ILE B 126
PRO B  61
 None
 1.39A 3w1wB-5khlB:
2.6		 3w1wB-5khlB:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 5khl HEMIN ABC
TRANSPORTER,
PERIPLASMIC
HEMIN-BINDING
PROTEIN HUTB
(Vibrio
cholerae) 		4 / 5 VAL B  54
LEU B  58
LEU B  60
ILE B  36
 None
 0.94A 4a9jC-5khlB:
undetectable		 4a9jC-5khlB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 5khl HEMIN ABC
TRANSPORTER,
PERIPLASMIC
HEMIN-BINDING
PROTEIN HUTB
(Vibrio
cholerae) 		5 / 12 THR B  80
PRO B  79
ILE B 107
VAL B  32
ILE B  36
 None
 1.01A 4eb6B-5khlB:
undetectable
4eb6C-5khlB:
undetectable		 4eb6B-5khlB:
18.57
4eb6C-5khlB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 5khl HEMIN ABC
TRANSPORTER,
PERIPLASMIC
HEMIN-BINDING
PROTEIN HUTB
(Vibrio
cholerae) 		5 / 9 LEU B 161
GLY B 243
ALA B 242
ASP B 212
ILE B 207
 None
 1.16A 4njtD-5khlB:
undetectable		 4njtD-5khlB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 5khl HEMIN ABC
TRANSPORTER,
PERIPLASMIC
HEMIN-BINDING
PROTEIN HUTB
(Vibrio
cholerae) 		5 / 12 GLY B 186
GLY B 183
LEU B 147
ASN B 189
LEU B 275
 None
 1.21A 4x61A-5khlB:
3.5		 4x61A-5khlB:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVG_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 5khl HEMIN ABC
TRANSPORTER,
PERIPLASMIC
HEMIN-BINDING
PROTEIN HUTB
(Vibrio
cholerae) 		5 / 12 LEU B 260
SER B 111
GLU B  87
ILE B 181
LEU B 256
 None
 0.73A 4yvgA-5khlB:
undetectable		 4yvgA-5khlB:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5khl HEMIN ABC
TRANSPORTER,
PERIPLASMIC
HEMIN-BINDING
PROTEIN HUTB
(Vibrio
cholerae) 		5 / 10 GLY B  89
LEU B  94
GLN B 122
ASN B 105
LEU B  74
 None
 1.23A 5fhzC-5khlB:
undetectable		 5fhzC-5khlB:
20.48