SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5khp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 5khp NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 10 ILE A 166
LEU A 137
GLY A  35
PHE A 168
TYR A 138
 None
 1.39A 1jujA-5khpA:
undetectable		 1jujA-5khpA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_A_LYAA315_1
(THYMIDYLATE SYNTHASE)		 5khp NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 10 LEU A 137
GLY A  35
PHE A 168
TYR A 138
MET A 120
 None
 1.47A 1jujA-5khpA:
undetectable		 1jujA-5khpA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 5khp NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 10 ILE A 166
LEU A 137
GLY A  35
PHE A 168
TYR A 138
 None
 1.39A 1jujB-5khpA:
undetectable		 1jujB-5khpA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_B_LYAB315_1
(THYMIDYLATE SYNTHASE)		 5khp NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 10 LEU A 137
GLY A  35
PHE A 168
TYR A 138
MET A 120
 None
 1.47A 1jujB-5khpA:
undetectable		 1jujB-5khpA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 5khp NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 10 ILE A 166
LEU A 137
GLY A  35
PHE A 168
TYR A 138
 None
 1.39A 1jujC-5khpA:
undetectable		 1jujC-5khpA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_C_LYAC315_1
(THYMIDYLATE SYNTHASE)		 5khp NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 10 LEU A 137
GLY A  35
PHE A 168
TYR A 138
MET A 120
 None
 1.47A 1jujC-5khpA:
undetectable		 1jujC-5khpA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 5khp NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 10 ILE A 166
LEU A 137
GLY A  35
PHE A 168
TYR A 138
 None
 1.40A 1jujD-5khpA:
undetectable		 1jujD-5khpA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JUJ_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 5khp NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 10 LEU A 137
GLY A  35
PHE A 168
TYR A 138
MET A 120
 None
 1.47A 1jujD-5khpA:
undetectable		 1jujD-5khpA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_2
(TRANSTHYRETIN)		 5khp NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		4 / 8 LEU A 144
THR A 136
LEU A 148
VAL A 121
 None
 0.92A 1sn5C-5khpA:
undetectable		 1sn5C-5khpA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 5khp NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 12 ILE A 153
LEU A 159
LEU A 137
GLY A  35
PHE A 168
 None
 1.13A 1tlsB-5khpA:
undetectable		 1tlsB-5khpA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 5khp NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 11 ILE A 153
LEU A 159
LEU A 137
GLY A  35
PHE A 168
 None
 1.25A 4fogD-5khpA:
undetectable		 4fogD-5khpA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 5khp NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 12 ILE A 166
LEU A 137
GLY A  35
PHE A 168
TYR A 138
 None
 1.35A 4foxE-5khpA:
undetectable		 4foxE-5khpA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 5khp NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		4 / 8 LEU A 144
THR A 136
LEU A 148
VAL A 121
 None
 0.95A 4ik6B-5khpA:
undetectable		 4ik6B-5khpA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5khp NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		3 / 3 TYR A 100
TYR A  56
SER A  68
 None
 0.78A 5iktB-5khpA:
undetectable		 5iktB-5khpA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 5khp NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN
(Homo
sapiens) 		5 / 12 ILE A 166
LEU A 137
GLY A  35
PHE A 168
TYR A 138
 None
 1.34A 6qyaB-5khpA:
undetectable		 6qyaB-5khpA:
20.58