SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kia'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 5kia L-THREONINE
3-DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 6 LEU A 203
ASP A 195
MET A 178
LEU A 308
 None
 1.13A 1errB-5kiaA:
undetectable		 1errB-5kiaA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 5kia L-THREONINE
3-DEHYDROGENASE
(Burkholderia
thailandensis) 		6 / 9 GLY A  87
VAL A  28
ILE A  69
GLY A  67
ILE A  32
ILE A 127
 None
 1.45A 1hpvA-5kiaA:
undetectable		 1hpvA-5kiaA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_C_MTXC353_1
(PTERIDINE REDUCTASE
1)		 5kia L-THREONINE
3-DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 ARG A  84
SER A  86
PHE A 133
TYR A 296
PRO A 136
 None
 1.50A 1p33C-5kiaA:
7.9		 1p33C-5kiaA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 5kia L-THREONINE
3-DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 7 SER A 248
LEU A 168
THR A 156
ILE A 175
 None
 0.97A 2bdmA-5kiaA:
undetectable		 2bdmA-5kiaA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 5kia L-THREONINE
3-DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 8 LEU A 220
SER A 240
VAL A 259
GLY A 236
 None
 1.11A 2qd5A-5kiaA:
3.4		 2qd5A-5kiaA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 5kia L-THREONINE
3-DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 9 ALA A 145
TYR A  65
ALA A 120
GLY A  62
ILE A  32
 None
 1.03A 2v7bA-5kiaA:
undetectable		 2v7bA-5kiaA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 5kia L-THREONINE
3-DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 9 ALA A 245
VAL A 242
GLY A 241
GLY A 263
ILE A 169
 None
 0.94A 2z0yA-5kiaA:
3.8		 2z0yA-5kiaA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 5kia L-THREONINE
3-DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 9 ALA A 245
VAL A 242
GLY A 241
GLY A 263
ILE A 169
 None
 0.97A 2z0yB-5kiaA:
3.4		 2z0yB-5kiaA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5kia L-THREONINE
3-DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 8 MET A 178
ALA A 179
GLY A 176
ILE A 175
 None
 0.69A 2zm9A-5kiaA:
undetectable		 2zm9A-5kiaA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_E_VDYE6178_1
(VITAMIN D
HYDROXYLASE)		 5kia L-THREONINE
3-DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 THR A 294
ILE A 182
ALA A 179
VAL A 167
LEU A 162
 None
 1.11A 3a51E-5kiaA:
undetectable		 3a51E-5kiaA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 5kia L-THREONINE
3-DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 THR A  54
VAL A 113
GLY A 112
THR A  40
ILE A  44
 None
 1.21A 3bf1A-5kiaA:
1.9
3bf1B-5kiaA:
2.2		 3bf1A-5kiaA:
20.75
3bf1B-5kiaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5kia L-THREONINE
3-DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 12 GLY A 236
VAL A 180
ASP A 234
LEU A 249
LEU A 250
 None
None
CA  A 402 (-2.4A)
None
None
 0.92A 3cjtC-5kiaA:
8.5		 3cjtC-5kiaA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5kia L-THREONINE
3-DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 10 ILE A  81
ILE A  69
VAL A  85
GLY A  67
VAL A  23
 None
 1.27A 3em0A-5kiaA:
undetectable		 3em0A-5kiaA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5kia L-THREONINE
3-DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 7 THR A 170
VAL A 192
THR A 194
VAL A 213
 None
 0.57A 3em0B-5kiaA:
undetectable		 3em0B-5kiaA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 5kia L-THREONINE
3-DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 6 ARG A  84
SER A  86
PHE A 133
PRO A 136
 None
 1.47A 3jqaB-5kiaA:
8.0		 3jqaB-5kiaA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 5kia L-THREONINE
3-DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 9 GLY A  62
ILE A  30
PHE A 133
PHE A 292
GLY A  89
 None
 1.33A 3ko0A-5kiaA:
undetectable
3ko0C-5kiaA:
undetectable		 3ko0A-5kiaA:
14.87
3ko0C-5kiaA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 5kia L-THREONINE
3-DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 10 PHE A 133
GLY A  87
GLY A 151
ILE A 139
PHE A  79
 None
None
CA  A 401 ( 4.8A)
None
None
 1.43A 3ko0L-5kiaA:
undetectable
3ko0N-5kiaA:
undetectable		 3ko0L-5kiaA:
14.87
3ko0N-5kiaA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 5kia L-THREONINE
3-DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 10 GLY A 151
ILE A 139
PHE A  79
PHE A 133
GLY A  87
 CA  A 401 ( 4.8A)
None
None
None
None
 1.46A 3ko0R-5kiaA:
undetectable
3ko0T-5kiaA:
undetectable		 3ko0R-5kiaA:
14.87
3ko0T-5kiaA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 5kia L-THREONINE
3-DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 5 SER A 240
GLY A 171
VAL A 215
ASP A 195
 None
 1.01A 4eohA-5kiaA:
undetectable		 4eohA-5kiaA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5kia L-THREONINE
3-DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 7 LEU A   4
ILE A  37
THR A  35
GLY A  62
 None
 0.95A 4eqlA-5kiaA:
undetectable		 4eqlA-5kiaA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5kia L-THREONINE
3-DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 8 GLY A 114
VAL A 113
HIS A  63
PHE A 325
 None
 0.94A 4fglD-5kiaA:
3.5		 4fglD-5kiaA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5kia L-THREONINE
3-DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 6 LEU A   4
ILE A  37
THR A  35
GLY A  62
 None
 0.94A 4l39A-5kiaA:
undetectable		 4l39A-5kiaA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5kia L-THREONINE
3-DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 7 LEU A   4
ILE A  37
THR A  35
GLY A  62
 None
 0.96A 4l39B-5kiaA:
undetectable		 4l39B-5kiaA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5kia L-THREONINE
3-DEHYDROGENASE
(Burkholderia
thailandensis) 		5 / 9 ALA A  36
THR A  35
ALA A 145
GLY A  62
ASP A 148
 None
None
None
None
CA  A 401 (-2.7A)
 1.06A 4qwuK-5kiaA:
undetectable
4qwuL-5kiaA:
undetectable		 4qwuK-5kiaA:
19.77
4qwuL-5kiaA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5kia L-THREONINE
3-DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 5 GLU A  64
THR A 154
HIS A 185
LEU A 308
 None
 1.22A 5axaA-5kiaA:
4.6		 5axaA-5kiaA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5kia L-THREONINE
3-DEHYDROGENASE
(Burkholderia
thailandensis) 		4 / 4 LEU A 308
TYR A 199
PRO A 174
ILE A 175
 None
 1.26A 5esgA-5kiaA:
undetectable		 5esgA-5kiaA:
20.83