SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kij'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 5kij ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		3 / 4 LYS A 416
ALA A 420
MET A 363
 None
 0.86A 1hk3A-5kijA:
undetectable		 1hk3A-5kijA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5kij ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		4 / 5 PHE A 518
GLY A 511
THR A 508
PHE A 509
 None
 1.38A 1icuC-5kijA:
undetectable
1icuD-5kijA:
undetectable		 1icuC-5kijA:
18.26
1icuD-5kijA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 5kij ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		5 / 12 LEU A 499
TYR A 466
PHE A 528
LEU A 529
TYR A 487
 None
 1.44A 1pj7A-5kijA:
undetectable		 1pj7A-5kijA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_B_CHDB500_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 5kij ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		4 / 4 LEU A 604
VAL A 601
ILE A 623
TRP A 619
 None
 1.48A 1s9qB-5kijA:
undetectable		 1s9qB-5kijA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 5kij ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		4 / 6 GLU A 330
ASN A 327
TRP A 284
SER A 658
 MAN  A 707 ( 4.2A)
MAN  A 713 (-3.7A)
None
None
 1.45A 3i9jB-5kijA:
undetectable		 3i9jB-5kijA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 5kij ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		3 / 3 ASP A 463
TRP A 389
SER A 400
 MAN  A 708 (-2.5A)
NAG  A 706 (-3.7A)
None
 1.06A 4lrhA-5kijA:
undetectable		 4lrhA-5kijA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5kij ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		3 / 4 ARG A 495
GLY A 493
GLU A 492
 None
 0.57A 4z2dB-5kijA:
undetectable
4z2dC-5kijA:
undetectable		 4z2dB-5kijA:
21.42
4z2dC-5kijA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 5kij ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		5 / 10 LEU A 408
ALA A 355
SER A 346
LEU A 345
ALA A 342
 None
 1.19A 4zbrA-5kijA:
undetectable		 4zbrA-5kijA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5kij ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		5 / 12 ILE A 372
GLU A 330
ALA A 462
VAL A 439
THR A 688
 None
MAN  A 707 ( 4.2A)
None
None
MAN  A 707 ( 3.2A)
 1.35A 5igpA-5kijA:
undetectable		 5igpA-5kijA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 5kij ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		5 / 12 LEU A 336
LEU A 339
ALA A 342
SER A 349
LEU A 350
 None
 1.18A 5mwyA-5kijA:
undetectable		 5mwyA-5kijA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 5kij ENDOPLASMIC
RETICULUM
MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E
(Homo
sapiens) 		4 / 7 GLN A 402
ASP A 486
ALA A 490
LEU A 438
 None
 1.05A 5nwvA-5kijA:
undetectable		 5nwvA-5kijA:
7.67