SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kin'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 5kin TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 ASP A  28
GLU A  52
ILE A  51
LEU A  43
ILE A 236
 None
 1.18A 1d1gB-5kinA:
undetectable		 1d1gB-5kinA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 10 LEU B 155
ALA B 124
VAL B 160
GLY B 117
PHE B 151
 None
 1.06A 1d4sA-5kinB:
undetectable		 1d4sA-5kinB:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DLS_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 ILE B 110
ALA B 112
ILE B  92
ASN B  93
LEU B  96
 None
None
LLP  B  91 ( 4.0A)
None
None
 1.24A 1dlsA-5kinB:
undetectable		 1dlsA-5kinB:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_A_115A2_2
(HMG-COA REDUCTASE)		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 8 GLU B  82
ASN B  85
LEU B  52
LEU B  48
 None
 0.98A 1hwiB-5kinB:
undetectable		 1hwiB-5kinB:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_D_115D3_1
(HMG-COA REDUCTASE)		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 8 GLU B  82
ASN B  85
LEU B  52
LEU B  48
 None
 1.01A 1hwiC-5kinB:
undetectable		 1hwiC-5kinB:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1866_0
(FPRA)		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 4 ARG B 214
LEU B  52
ASN B  49
VAL B 211
 None
 1.28A 1lqtA-5kinB:
undetectable		 1lqtA-5kinB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1875_0
(FPRA)		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 4 ARG B 214
LEU B  52
ASN B  49
VAL B 211
 None
 1.29A 1lqtB-5kinB:
2.5		 1lqtB-5kinB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1423_0
(FPRA)		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 4 ARG B 214
LEU B  52
ASN B  49
VAL B 211
 None
 1.29A 1lquA-5kinB:
1.6		 1lquA-5kinB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1432_0
(FPRA)		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 4 ARG B 214
LEU B  52
ASN B  49
VAL B 211
 None
 1.29A 1lquB-5kinB:
1.2		 1lquB-5kinB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 GLY B 238
GLY B 237
SER B 240
LEU B 309
LEU B 192
 LLP  B  91 ( 3.6A)
LLP  B  91 ( 3.6A)
LLP  B  91 ( 2.6A)
None
None
 1.13A 1ya4B-5kinB:
2.4		 1ya4B-5kinB:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5kin TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 VAL A 208
LEU A 209
LEU A 200
ILE A 151
GLY A 172
 None
 1.08A 2aylB-5kinA:
undetectable		 2aylB-5kinA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 5kin TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 ALA A 204
ASP A 205
ILE A 160
ALA A 176
VAL A 208
 None
 0.90A 2b7zA-5kinA:
undetectable		 2b7zA-5kinA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 5kin TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 HIS A 201
ALA A 176
LEU A 166
ASP A 228
GLY A 211
 None
 1.11A 2f8lA-5kinA:
undetectable		 2f8lA-5kinA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 GLY B 349
ASN B  67
LEU B  68
GLY B 384
PHE B 341
 None
 1.09A 2f8lA-5kinB:
2.2		 2f8lA-5kinB:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YK1_H_NCTH300_1
(FAB FRAGMENT, HEAVY
CHAIN
FAB FRAGMENT, LIGHT
CHAIN)		 5kin TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Streptococcus
pneumoniae) 		5 / 10 ILE A  67
GLY A 233
SER A 234
GLU A  52
TYR A 175
 None
 1.28A 2yk1H-5kinA:
undetectable
2yk1L-5kinA:
undetectable		 2yk1H-5kinA:
23.81
2yk1L-5kinA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 5kin TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Streptococcus
pneumoniae) 		5 / 11 ALA A  70
ASP A  28
ILE A  51
LEU A  43
ILE A 236
 None
 1.03A 3clbA-5kinA:
undetectable		 3clbA-5kinA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5kin TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Streptococcus
pneumoniae) 		5 / 10 ALA A  70
ASP A  28
ILE A  51
LEU A  43
ILE A 236
 None
 1.02A 3hbbA-5kinA:
undetectable		 3hbbA-5kinA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5kin TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Streptococcus
pneumoniae) 		5 / 11 ALA A  70
ASP A  28
ILE A  51
LEU A  43
ILE A 236
 None
 1.07A 3hbbC-5kinA:
undetectable		 3hbbC-5kinA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 5kin TRYPTOPHAN SYNTHASE
ALPHA CHAIN
TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae;
Streptococcus
pneumoniae) 		4 / 6 ASP A  59
LEU B 284
ASP B 294
LEU B 300
 None
 0.98A 3rozA-5kinA:
undetectable		 3rozA-5kinA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 5kin TRYPTOPHAN SYNTHASE
ALPHA CHAIN
TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 10 PHE A 138
PHE A 107
VAL B 283
PHE A 103
GLY B  16
 None
 1.29A 3t3rD-5kinA:
undetectable		 3t3rD-5kinA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 LEU B  79
GLY B 340
LEU B 343
PHE B 341
SER B 345
 None
 1.21A 3tbgA-5kinB:
undetectable		 3tbgA-5kinB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 LEU B  79
GLY B 340
LEU B 343
PHE B 341
SER B 345
 None
 1.20A 3tbgC-5kinB:
undetectable		 3tbgC-5kinB:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 LEU B  79
TYR B  63
ILE B  77
ILE B  72
LEU B 343
 None
 0.98A 3uj6A-5kinB:
undetectable		 3uj6A-5kinB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 11 ALA B 112
GLY B 139
GLY B 115
ILE B 136
ASP B 142
 None
 1.12A 4dcmA-5kinB:
undetectable		 4dcmA-5kinB:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 5kin TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Streptococcus
pneumoniae) 		5 / 9 ILE A 128
THR A 101
LEU A 106
VAL A 111
VAL A 123
 GOL  A 301 (-4.5A)
None
None
None
None
 0.91A 4g1bC-5kinA:
undetectable		 4g1bC-5kinA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G2Z_A_ID8A711_1
(LACTOTRANSFERRIN)		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		3 / 3 PRO B 202
TYR B  12
GLY B 315
 None
 0.58A 4g2zA-5kinB:
undetectable		 4g2zA-5kinB:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 GLY B 244
GLN B 209
GLN B 219
ILE B 377
PHE B 249
 None
LLP  B  91 ( 4.6A)
None
None
None
 1.30A 4p6xA-5kinB:
undetectable		 4p6xA-5kinB:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 GLY B 244
GLN B 209
GLN B 219
ILE B 377
PHE B 249
 None
LLP  B  91 ( 4.6A)
None
None
None
 1.30A 4p6xE-5kinB:
undetectable		 4p6xE-5kinB:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 GLY B 244
GLN B 209
GLN B 219
ILE B 377
PHE B 249
 None
LLP  B  91 ( 4.6A)
None
None
None
 1.33A 4p6xI-5kinB:
undetectable		 4p6xI-5kinB:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_K_HCYK900_1
(GLUCOCORTICOID
RECEPTOR)		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 GLY B 244
GLN B 209
GLN B 219
ILE B 377
PHE B 249
 None
LLP  B  91 ( 4.6A)
None
None
None
 1.24A 4p6xK-5kinB:
undetectable		 4p6xK-5kinB:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		5 / 12 GLY B 315
SER B 319
SER B 194
LEU B 288
HIS B 285
 None
None
LLP  B  91 ( 3.0A)
None
None
 1.05A 4qdjA-5kinB:
undetectable		 4qdjA-5kinB:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5kin TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae) 		4 / 6 SER B  38
ASP B 207
GLN B  45
GLU B 203
 None
 1.42A 6djzA-5kinB:
undetectable		 6djzA-5kinB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 5kin TRYPTOPHAN SYNTHASE
ALPHA CHAIN
TRYPTOPHAN SYNTHASE
BETA CHAIN
(Streptococcus
pneumoniae;
Streptococcus
pneumoniae) 		5 / 12 LEU A 131
PHE B  19
GLY B  17
PHE B  11
ASP B   9
 GOL  A 301 (-4.8A)
None
None
None
None
 1.01A 6dwnA-5kinA:
undetectable		 6dwnA-5kinA:
16.60