SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kis'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_A_C2FA801_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 5kis RHS2
(Yersinia
entomophaga) 		5 / 12 ASN B 445
ARG B 446
ASP B  57
GLY B 669
ARG B 649
 None
 1.37A 1q8jA-5kisB:
undetectable		 1q8jA-5kisB:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5kis RHS2
(Yersinia
entomophaga) 		3 / 3 SER B 510
GLY B 509
ARG B 122
 None
 0.41A 1t9wA-5kisB:
undetectable		 1t9wA-5kisB:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 5kis RHS2
(Yersinia
entomophaga) 		3 / 3 ASP B 587
TYR B 586
GLU B 292
 None
 0.81A 1vm1A-5kisB:
undetectable		 1vm1A-5kisB:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 5kis RHS2
(Yersinia
entomophaga) 		5 / 12 VAL B 342
SER B 376
ARG B 411
GLY B 614
TYR B 409
 None
None
CL  B1002 (-4.2A)
None
None
 1.37A 1xvaA-5kisB:
undetectable		 1xvaA-5kisB:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5kis RHS2
(Yersinia
entomophaga) 		5 / 12 LEU B 392
GLU B 596
SER B 593
ALA B 626
ALA B 623
 None
 1.18A 2bm9D-5kisB:
undetectable		 2bm9D-5kisB:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 5kis RHS2
(Yersinia
entomophaga) 		4 / 5 TYR B 584
TYR B 586
ILE B 300
GLY B 295
 None
 1.30A 2du8G-5kisB:
undetectable		 2du8G-5kisB:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 5kis RHS2
(Yersinia
entomophaga) 		5 / 12 LEU B 167
LEU B 170
GLY B 169
VAL B 154
THR B 159
 None
 1.50A 2q7lA-5kisB:
undetectable		 2q7lA-5kisB:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_B_LNRB200_1
(D7R4 PROTEIN)		 5kis RHS2
(Yersinia
entomophaga) 		5 / 10 GLU B 537
ARG B 539
ILE B 513
ASP B 639
GLU B 637
 None
 1.43A 2qeoB-5kisB:
undetectable		 2qeoB-5kisB:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 5kis RHS2
(Yersinia
entomophaga) 		5 / 12 VAL B 269
ASP B 246
LEU B 536
SER B 550
LEU B 551
 None
 1.11A 2w3vA-5kisB:
undetectable		 2w3vA-5kisB:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5kis RHS2
(Yersinia
entomophaga) 		4 / 8 TYR B 612
TYR B 413
GLN B 388
ILE B 438
 None
CL  B1002 (-4.8A)
None
None
 1.11A 2xz5B-5kisB:
undetectable
2xz5E-5kisB:
undetectable		 2xz5B-5kisB:
13.80
2xz5E-5kisB:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5kis RHS2
(Yersinia
entomophaga) 		4 / 7 GLN B 388
ILE B 438
TYR B 612
TYR B 413
 None
None
None
CL  B1002 (-4.8A)
 1.10A 2xz5D-5kisB:
undetectable
2xz5E-5kisB:
undetectable		 2xz5D-5kisB:
13.80
2xz5E-5kisB:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5kis RHS2
(Yersinia
entomophaga) 		4 / 6 GLY B 591
TYR B 609
GLY B 635
ASN B 588
 None
 0.96A 3e9rA-5kisB:
undetectable		 3e9rA-5kisB:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5kis RHS2
(Yersinia
entomophaga) 		4 / 6 GLY B 591
TYR B 609
GLY B 635
ASN B 588
 None
 0.94A 3e9rC-5kisB:
undetectable		 3e9rC-5kisB:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5kis RHS2
(Yersinia
entomophaga) 		5 / 12 ILE B 424
ASN B 364
VAL B 342
LEU B 589
THR B 590
 CL  B1002 ( 4.9A)
None
None
None
None
 1.30A 3em0B-5kisB:
3.6		 3em0B-5kisB:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 5kis RHS2
(Yersinia
entomophaga) 		3 / 3 GLU B 363
GLY B 379
THR B 378
 None
 0.57A 3iazA-5kisB:
undetectable		 3iazA-5kisB:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 5kis RHS2
(Yersinia
entomophaga) 		3 / 3 ASN B 420
ALA B 418
ARG B  59
 None
 0.86A 3tj7C-5kisB:
undetectable
3tj7D-5kisB:
undetectable		 3tj7C-5kisB:
11.24
3tj7D-5kisB:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 5kis RHS2
(Yersinia
entomophaga) 		4 / 6 LEU B 165
ALA B 161
LEU B 167
THR B 159
 None
 1.01A 4d7bB-5kisB:
undetectable		 4d7bB-5kisB:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 5kis RHS2
(Yersinia
entomophaga) 		4 / 8 GLU B 292
GLN B 288
GLY B 287
SER B 284
 None
 0.92A 4f93B-5kisB:
undetectable		 4f93B-5kisB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 5kis RHS2
(Yersinia
entomophaga) 		4 / 6 LEU B 165
ALA B 161
LEU B 167
THR B 159
 None
 1.06A 4ikiB-5kisB:
undetectable		 4ikiB-5kisB:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWJ_B_30ZB201_1
(TRANSTHYRETIN)		 5kis RHS2
(Yersinia
entomophaga) 		4 / 7 LEU B 165
ALA B 161
LEU B 167
THR B 159
 None
 1.02A 4pwjB-5kisB:
undetectable		 4pwjB-5kisB:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 5kis RHS2
(Yersinia
entomophaga) 		4 / 5 GLY B 614
TYR B 646
TYR B 633
GLY B 635
 None
 1.06A 5ayfA-5kisB:
undetectable		 5ayfA-5kisB:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_B_4TXB201_1
(TRANSTHYRETIN)		 5kis RHS2
(Yersinia
entomophaga) 		4 / 7 LEU B 165
ALA B 161
LEU B 167
THR B 159
 None
 1.02A 5bojB-5kisB:
undetectable		 5bojB-5kisB:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 5kis RHS2
(Yersinia
entomophaga) 		3 / 3 ASN B  86
SER B  89
SER B 104
 None
 0.78A 5gsnA-5kisB:
undetectable		 5gsnA-5kisB:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 5kis RHS2
(Yersinia
entomophaga) 		4 / 7 LEU B 595
THR B 619
THR B 396
LEU B 329
 None
 1.06A 5jq7B-5kisB:
undetectable		 5jq7B-5kisB:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 5kis RHS2
(Yersinia
entomophaga) 		4 / 8 TRP B 480
THR B 470
ARG B 657
GLN B 652
 None
 1.26A 5tzoA-5kisB:
undetectable		 5tzoA-5kisB:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 5kis RHS2
(Yersinia
entomophaga) 		5 / 12 LEU B 478
ALA B 661
ALA B 447
ILE B 438
GLY B 656
 None
 1.00A 5veuB-5kisB:
undetectable		 5veuB-5kisB:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5kis RHS2
(Yersinia
entomophaga) 		4 / 6 ARG B 529
LYS B 515
LEU B 514
LEU B 199
 None
 1.08A 5w97C-5kisB:
undetectable
5w97J-5kisB:
undetectable		 5w97C-5kisB:
12.64
5w97J-5kisB:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 5kis RHS2
(Yersinia
entomophaga) 		4 / 6 GLU B 637
ARG B 512
ALA B 530
LYS B 515
 None
 1.12A 6an0A-5kisB:
undetectable		 6an0A-5kisB:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C79_A_CE3A301_1
(BETA-LACTAMASE
TOHO-1)		 5kis RHS2
(Yersinia
entomophaga) 		6 / 12 ALA B  84
ASN B 671
TYR B 673
ASN B 445
ASN B  67
GLY B  83
 None
 1.42A 6c79A-5kisB:
undetectable		 6c79A-5kisB:
6.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CCV_C_RFPC1205_1
(-)		 5kis RHS2
(Yersinia
entomophaga) 		5 / 12 GLN B 473
GLN B 652
ARG B 657
LEU B 449
ILE B 438
 None
 1.40A 6ccvC-5kisB:
1.8		 6ccvC-5kisB:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 5kis RHS2
(Yersinia
entomophaga) 		4 / 7 ASP B 348
ASN B 347
GLU B 335
LEU B 332
 None
 1.05A 6ci6A-5kisB:
undetectable		 6ci6A-5kisB:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA810_0
(UNCHARACTERIZED
PROTEIN)		 5kis RHS2
(Yersinia
entomophaga) 		4 / 6 HIS B 426
TYR B 434
TYR B 610
GLN B 388
 None
 1.39A 6d8pA-5kisB:
undetectable		 6d8pA-5kisB:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 5kis RHS2
(Yersinia
entomophaga) 		5 / 12 VAL B 676
ARG B 411
GLN B 388
PRO B 653
GLY B 656
 None
CL  B1002 (-4.2A)
None
None
None
 1.21A 6gnfA-5kisB:
undetectable		 6gnfA-5kisB:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 5kis RHS2
(Yersinia
entomophaga) 		5 / 12 VAL B 676
ARG B 411
GLN B 388
PRO B 653
GLY B 656
 None
CL  B1002 (-4.2A)
None
None
None
 1.20A 6gnfC-5kisB:
undetectable		 6gnfC-5kisB:
19.71