SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kiv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 5kiv PROTEIN-ADP-RIBOSE
HYDROLASE
(Staphylococcus
aureus) 		4 / 5 ARG A 134
ARG A  42
GLY A  43
GLU A  39
 None
 1.03A 3k9fA-5kivA:
undetectable
3k9fB-5kivA:
undetectable
3k9fC-5kivA:
2.2		 3k9fA-5kivA:
19.52
3k9fB-5kivA:
19.52
3k9fC-5kivA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 5kiv PROTEIN-ADP-RIBOSE
HYDROLASE
(Staphylococcus
aureus) 		4 / 6 ARG A 134
ARG A  42
GLY A  43
GLU A  39
 None
 1.03A 3k9fA-5kivA:
undetectable
3k9fB-5kivA:
undetectable
3k9fD-5kivA:
2.0		 3k9fA-5kivA:
19.52
3k9fB-5kivA:
19.52
3k9fD-5kivA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_D_NCAD302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 5kiv PROTEIN-ADP-RIBOSE
HYDROLASE
(Staphylococcus
aureus) 		4 / 7 LEU A  65
ASP A  62
ALA A  63
TYR A  41
 None
 1.07A 3rodD-5kivA:
undetectable		 3rodD-5kivA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5kiv PROTEIN-ADP-RIBOSE
HYDROLASE
(Staphylococcus
aureus) 		4 / 8 TYR A  13
TYR A  57
ARG A  48
LEU A  44
 None
EOH  A 303 (-2.7A)
EOH  A 303 ( 3.8A)
None
 1.29A 3wipG-5kivA:
undetectable
3wipH-5kivA:
undetectable		 3wipG-5kivA:
20.59
3wipH-5kivA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5kiv PROTEIN-ADP-RIBOSE
HYDROLASE
(Staphylococcus
aureus) 		3 / 3 ASP A  93
ARG A  42
THR A  96
 None
 0.85A 4i13A-5kivA:
undetectable		 4i13A-5kivA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5kiv PROTEIN-ADP-RIBOSE
HYDROLASE
(Staphylococcus
aureus) 		3 / 3 ASP A  93
ARG A  42
THR A  96
 None
 0.83A 4p3rA-5kivA:
undetectable		 4p3rA-5kivA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 5kiv PROTEIN-ADP-RIBOSE
HYDROLASE
(Staphylococcus
aureus) 		3 / 3 HIS A  70
ASN A  69
LEU A  68
 None
None
EOH  A 305 ( 3.4A)
 0.87A 6f7lB-5kivA:
undetectable		 6f7lB-5kivA:
21.43