SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kj2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 5kj2 HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		4 / 7 ASP A1614
ASP A1616
TYR A1421
TYR A1424
 None
 1.46A 1ceaB-5kj2A:
undetectable		 1ceaB-5kj2A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_B_AMHB90_1
(PLASMINOGEN)		 5kj2 HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		4 / 7 ASP A1614
ASP A1616
TYR A1421
TYR A1424
 None
 1.44A 1cebB-5kj2A:
undetectable		 1cebB-5kj2A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 5kj2 HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		3 / 3 TRP A1436
VAL A1597
TRP A1509
 None
 1.36A 1gmkC-5kj2A:
undetectable
1gmkD-5kj2A:
undetectable		 1gmkC-5kj2A:
3.83
1gmkD-5kj2A:
3.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 5kj2 HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		5 / 12 TYR A1585
ILE A1517
SER A1516
SER A1497
PHE A1343
 None
 1.07A 1ve3B-5kj2A:
undetectable		 1ve3B-5kj2A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 5kj2 HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		4 / 6 ILE A1479
TYR A1421
ILE A1598
HIS A1481
 None
 1.22A 3eteA-5kj2A:
2.6
3eteE-5kj2A:
undetectable		 3eteA-5kj2A:
23.32
3eteE-5kj2A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 5kj2 HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		4 / 5 ILE A1479
TYR A1421
ILE A1598
HIS A1481
 None
 1.21A 3eteB-5kj2A:
undetectable
3eteC-5kj2A:
undetectable		 3eteB-5kj2A:
23.32
3eteC-5kj2A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5kj2 HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		4 / 4 VAL A1326
PHE A1361
PHE A1373
VAL A1321
 None
 1.35A 3rv5C-5kj2A:
undetectable
3rv5D-5kj2A:
undetectable		 3rv5C-5kj2A:
11.78
3rv5D-5kj2A:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 5kj2 HISTONE
ACETYLTRANSFERASE
P300
(Homo
sapiens) 		3 / 3 TYR A1397
ASP A1628
ASP A1625
 None
 0.64A 4a6eA-5kj2A:
undetectable		 4a6eA-5kj2A:
20.88