SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kj8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 5kj8 SYNAPTOTAGMIN-1
(Rattus
norvegicus) 		4 / 7 SER E 308
LEU E 299
GLY E 374
ILE E 314
 None
 0.93A 2bdmA-5kj8E:
undetectable		 2bdmA-5kj8E:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8O_A_OINA1314_1
(CHOLINE-BINDING
PROTEIN F)		 5kj8 SYNAPTOTAGMIN-1
(Rattus
norvegicus) 		4 / 5 LYS E 144
ASP E 261
ARG E 260
GLU E 258
 None
 1.43A 2x8oA-5kj8E:
undetectable		 2x8oA-5kj8E:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5kj8 SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 25
SYNAPTOTAGMIN-1
(Rattus
norvegicus;
Rattus
norvegicus) 		5 / 12 VAL C  48
VAL E 359
LEU E 289
PHE E 343
VAL E 357
 None
 1.10A 3w68B-5kj8C:
undetectable		 3w68B-5kj8C:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 5kj8 SYNAPTOTAGMIN-1
(Rattus
norvegicus) 		5 / 9 VAL E 359
VAL E 358
GLU E 386
ILE E 276
GLY E 374
 None
 1.13A 4fwdA-5kj8E:
undetectable		 4fwdA-5kj8E:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		 5kj8 SYNAPTOTAGMIN-1
(Rattus
norvegicus) 		4 / 6 ASP E 232
ASP E 172
ALA E 170
ASP E 238
 CA  E 503 (-2.6A)
CA  E 504 ( 2.7A)
None
None
 1.21A 4mdaA-5kj8E:
undetectable		 4mdaA-5kj8E:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5kj8 SYNAPTOTAGMIN-1
(Rattus
norvegicus) 		4 / 6 SER E 148
MET E 226
LEU E 159
LEU E 158
 None
 1.33A 5dzke-5kj8E:
undetectable
5dzks-5kj8E:
undetectable		 5dzke-5kj8E:
21.20
5dzks-5kj8E:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 5kj8 SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 25
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 25
(Rattus
norvegicus;
Rattus
norvegicus) 		4 / 7 ILE D 181
GLN D 177
GLU C  55
VAL C  60
 None
CA  C 101 ( 4.0A)
None
None
 1.20A 6j20A-5kj8D:
undetectable		 6j20A-5kj8D:
9.74