SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kjz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5kjz CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Homo
sapiens) 		3 / 3 SER A 251
GLU A 247
GLU A 248
 None
 0.70A 1eqbD-5kjzA:
undetectable		 1eqbD-5kjzA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5kjz CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Homo
sapiens) 		3 / 3 SER A 251
GLU A 247
GLU A 248
 None
 0.71A 1eqbB-5kjzA:
undetectable		 1eqbB-5kjzA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 5kjz CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Homo
sapiens) 		4 / 6 PRO A 353
LEU A 329
ARG A 357
GLY A 360
 None
 0.95A 2hs2B-5kjzA:
undetectable		 2hs2B-5kjzA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)		 5kjz CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Homo
sapiens) 		5 / 12 VAL A 283
ALA A 337
PHE A 324
ILE A 282
THR A 336
 None
PCG  A 401 (-4.0A)
None
None
PCG  A 401 (-3.0A)
 0.85A 2w3vA-5kjzA:
undetectable		 2w3vA-5kjzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 5kjz CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Homo
sapiens) 		5 / 10 VAL A 283
ALA A 337
ILE A 295
ILE A 282
THR A 336
 None
PCG  A 401 (-4.0A)
None
None
PCG  A 401 (-3.0A)
 1.22A 3clbD-5kjzA:
undetectable		 3clbD-5kjzA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5kjz CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Homo
sapiens) 		5 / 10 VAL A 283
ALA A 337
ILE A 295
ILE A 282
THR A 336
 None
PCG  A 401 (-4.0A)
None
None
PCG  A 401 (-3.0A)
 1.23A 3hbbD-5kjzA:
undetectable		 3hbbD-5kjzA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5kjz CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Homo
sapiens) 		4 / 4 GLU A 297
PRO A 320
ILE A 295
LEU A 296
 None
 1.03A 5m45A-5kjzA:
undetectable		 5m45A-5kjzA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5kjz CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Homo
sapiens) 		4 / 4 GLU A 297
PRO A 320
ILE A 295
LEU A 296
 None
 1.05A 5m45D-5kjzA:
undetectable		 5m45D-5kjzA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5kjz CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Homo
sapiens) 		4 / 4 GLU A 297
PRO A 320
ILE A 295
LEU A 296
 None
 1.01A 5m45G-5kjzA:
undetectable		 5m45G-5kjzA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 5kjz CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Homo
sapiens) 		4 / 4 GLU A 297
PRO A 320
ILE A 295
LEU A 296
 None
 1.03A 5m45J-5kjzA:
undetectable		 5m45J-5kjzA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 5kjz CAMP-DEPENDENT
PROTEIN KINASE TYPE
I-ALPHA REGULATORY
SUBUNIT
(Homo
sapiens) 		4 / 6 ASN A 374
TYR A 373
VAL A 377
VAL A 315
 GOL  A 402 (-4.2A)
PCG  A 401 (-3.8A)
None
PCG  A 401 (-4.5A)
 1.04A 6f32B-5kjzA:
undetectable		 6f32B-5kjzA:
15.80