SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kk8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 5kk8 NUCLEOSIDE
DIPHOSPHATE KINASE
(Schistosoma
mansoni) 		3 / 3 GLU A 121
ALA A 123
SER A 117
 None
 0.68A 1errB-5kk8A:
undetectable		 1errB-5kk8A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)		 5kk8 NUCLEOSIDE
DIPHOSPHATE KINASE
(Schistosoma
mansoni) 		4 / 6 MET A  65
VAL A  62
LEU A  61
PHE A  57
 None
None
ADP  A 201 (-4.0A)
ADP  A 201 ( 4.0A)
 1.01A 1x8vA-5kk8A:
undetectable		 1x8vA-5kk8A:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 5kk8 NUCLEOSIDE
DIPHOSPHATE KINASE
(Schistosoma
mansoni) 		4 / 8 MET A  65
LEU A  61
ARG A 102
GLY A 116
 None
ADP  A 201 (-4.0A)
ADP  A 201 (-3.4A)
None
 1.08A 2qd5A-5kk8A:
undetectable		 2qd5A-5kk8A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 5kk8 NUCLEOSIDE
DIPHOSPHATE KINASE
(Schistosoma
mansoni) 		4 / 8 LEU A 129
ARG A 125
TYR A  49
GLU A  50
 None
 1.40A 3zmdA-5kk8A:
undetectable
3zmdB-5kk8A:
undetectable		 3zmdA-5kk8A:
22.60
3zmdB-5kk8A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 5kk8 NUCLEOSIDE
DIPHOSPHATE KINASE
(Schistosoma
mansoni) 		4 / 6 HIS A 115
GLU A 126
ASP A 118
SER A 122
 None
 1.22A 4apjA-5kk8A:
undetectable
4apjP-5kk8A:
undetectable		 4apjA-5kk8A:
13.32
4apjP-5kk8A:
5.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 5kk8 NUCLEOSIDE
DIPHOSPHATE KINASE
(Schistosoma
mansoni) 		4 / 6 GLY A 103
ARG A  15
GLU A  20
ARG A  24
 None
 0.91A 4bqfA-5kk8A:
undetectable		 4bqfA-5kk8A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 5kk8 NUCLEOSIDE
DIPHOSPHATE KINASE
(Schistosoma
mansoni) 		3 / 4 ARG A  78
GLY A  77
GLU A   2
 None
 0.61A 4z2dB-5kk8A:
undetectable
4z2dC-5kk8A:
undetectable		 4z2dB-5kk8A:
14.37
4z2dC-5kk8A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 5kk8 NUCLEOSIDE
DIPHOSPHATE KINASE
(Schistosoma
mansoni) 		5 / 12 LEU A 136
SER A 132
ASN A 128
GLU A 126
LEU A 129
 None
 1.18A 5nwvA-5kk8A:
undetectable		 5nwvA-5kk8A:
15.15