SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kkb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		4 / 6 GLU A 611
THR A 553
TYR A 556
TYR A 420
 MAN  A 709 ( 2.8A)
None
None
None
 1.25A 1qvuA-5kkbA:
undetectable		 1qvuA-5kkbA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z35_A_2FAA300_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		5 / 10 MET A 483
THR A 477
GLY A 412
THR A 635
GLU A 549
 None
None
MAN  A 707 ( 3.5A)
MAN  A 709 (-3.1A)
MAN  A 709 ( 3.3A)
 1.40A 1z35A-5kkbA:
undetectable		 1z35A-5kkbA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		4 / 7 PHE A 526
TYR A 544
PRO A 523
THR A 517
 None
 1.43A 2q6kA-5kkbA:
undetectable		 2q6kA-5kkbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		5 / 12 VAL A 375
SER A 416
THR A 635
ASN A 634
ALA A 424
 None
MAN  A 708 ( 4.7A)
MAN  A 709 (-3.1A)
None
None
 1.27A 2x2iA-5kkbA:
undetectable		 2x2iA-5kkbA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		4 / 4 ARG A 337
GLY A 336
GLU A 277
SER A 322
 None
 1.11A 2xctS-5kkbA:
undetectable
2xctU-5kkbA:
undetectable		 2xctS-5kkbA:
21.78
2xctU-5kkbA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		5 / 12 LEU A 250
GLY A 290
ILE A 285
ASN A 634
PHE A 235
 None
 1.31A 2zznB-5kkbA:
undetectable		 2zznB-5kkbA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		4 / 5 SER A 606
LEU A 219
GLY A 240
GLU A 221
 None
 1.12A 3aiaA-5kkbA:
undetectable
3aiaB-5kkbA:
undetectable		 3aiaA-5kkbA:
17.14
3aiaB-5kkbA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		5 / 12 GLY A 586
GLY A 585
VAL A 583
LEU A 577
ILE A 225
 None
 1.13A 3h52B-5kkbA:
undetectable		 3h52B-5kkbA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		5 / 12 GLY A 289
GLY A 311
ASP A 368
ASN A 284
PHE A 359
 None
 1.31A 3qowA-5kkbA:
undetectable		 3qowA-5kkbA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		4 / 6 ASN A 394
PHE A 417
ALA A 350
THR A 354
 None
None
MAN  A 708 ( 3.3A)
None
 1.19A 3t3sB-5kkbA:
undetectable		 3t3sB-5kkbA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		5 / 12 LEU A 314
ALA A 307
LEU A 270
MET A 331
PHE A 371
 None
 1.41A 3vhuA-5kkbA:
undetectable		 3vhuA-5kkbA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		4 / 7 PHE A 479
VAL A 410
ILE A 446
GLU A 552
 None
None
None
LA  A 711 ( 4.6A)
 1.15A 4a97H-5kkbA:
undetectable		 4a97H-5kkbA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		4 / 8 ASN A 394
GLY A 414
ILE A 461
PHE A 484
 None
 0.64A 4fglD-5kkbA:
undetectable		 4fglD-5kkbA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		5 / 12 ASP A 245
PHE A 281
LEU A 291
LEU A 310
HIS A 638
 None
MAN  A 708 ( 4.3A)
None
None
None
 1.13A 4j03A-5kkbA:
undetectable		 4j03A-5kkbA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		5 / 11 PHE A 281
GLY A 411
GLY A 412
LEU A 476
GLU A 524
 MAN  A 708 ( 4.3A)
None
MAN  A 707 ( 3.5A)
MAN  A 708 ( 4.1A)
MAN  A 707 ( 4.7A)
 1.13A 4l8fB-5kkbA:
undetectable		 4l8fB-5kkbA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		5 / 11 PHE A 281
GLY A 411
GLY A 412
LEU A 476
GLU A 524
 MAN  A 708 ( 4.3A)
None
MAN  A 707 ( 3.5A)
MAN  A 708 ( 4.1A)
MAN  A 707 ( 4.7A)
 1.17A 4l8fD-5kkbA:
undetectable		 4l8fD-5kkbA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		3 / 3 HIS A 407
TRP A 464
SER A 343
 None
 1.21A 4lrhD-5kkbA:
undetectable		 4lrhD-5kkbA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		5 / 12 GLY A 481
GLY A 503
THR A 553
ILE A 551
THR A 612
 None
 1.25A 4n48A-5kkbA:
undetectable		 4n48A-5kkbA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB302_1
(CHITOSANASE)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		4 / 5 GLU A 419
ILE A 285
THR A 354
TYR A 615
 LA  A 711 ( 4.4A)
None
None
None
 1.18A 4qwpB-5kkbA:
undetectable		 4qwpB-5kkbA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		3 / 3 GLU A 419
TYR A 615
GLU A 611
 LA  A 711 ( 4.4A)
None
MAN  A 709 ( 2.8A)
 0.79A 4ryaA-5kkbA:
undetectable		 4ryaA-5kkbA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		5 / 12 ALA A 480
THR A 477
MET A 557
THR A 509
ALA A 485
 None
 1.22A 4ypmA-5kkbA:
undetectable		 4ypmA-5kkbA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		4 / 7 GLU A 470
ARG A 538
GLU A 541
ALA A 525
 None
 1.09A 4zz8A-5kkbA:
undetectable		 4zz8A-5kkbA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		4 / 5 SER A 322
ARG A 337
GLY A 336
GLU A 277
 None
 1.00A 5cdqA-5kkbA:
undetectable
5cdqB-5kkbA:
undetectable
5cdqC-5kkbA:
undetectable		 5cdqA-5kkbA:
22.92
5cdqB-5kkbA:
19.85
5cdqC-5kkbA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		4 / 5 SER A 322
ARG A 337
GLY A 336
GLU A 277
 None
 0.99A 5cdqR-5kkbA:
undetectable
5cdqS-5kkbA:
undetectable
5cdqT-5kkbA:
undetectable		 5cdqR-5kkbA:
22.92
5cdqS-5kkbA:
19.85
5cdqT-5kkbA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		3 / 3 TRP A 326
ILE A 324
SER A 322
 None
 0.99A 5gqbA-5kkbA:
undetectable		 5gqbA-5kkbA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		4 / 7 ILE A 243
HIS A 638
LEU A 291
ALA A 294
 None
 1.00A 5hrqE-5kkbA:
undetectable
5hrqF-5kkbA:
undetectable
5hrqJ-5kkbA:
undetectable		 5hrqE-5kkbA:
6.51
5hrqF-5kkbA:
4.59
5hrqJ-5kkbA:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		5 / 12 LEU A 616
LEU A 613
ALA A 610
SER A 606
LEU A 546
 None
 1.07A 5mwyA-5kkbA:
undetectable		 5mwyA-5kkbA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 5kkb MANNOSYL-OLIGOSACCHA
RIDE
1,2-ALPHA-MANNOSIDAS
E IA
(Mus
musculus) 		4 / 7 LEU A 413
ALA A 350
THR A 354
THR A 635
 None
MAN  A 708 ( 3.3A)
None
MAN  A 709 (-3.1A)
 0.85A 6a7jA-5kkbA:
undetectable		 6a7jA-5kkbA:
12.88