SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kkg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKB_A_RAPA108_1
(FK506 BINDING
PROTEIN)		 5kkg ANCMT E72A
(synthetic
construct) 		5 / 12 GLN A 183
ILE A  65
HIS A  63
ILE A  44
PHE A 172
 None
 1.21A 1fkbA-5kkgA:
undetectable		 1fkbA-5kkgA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_A_TESA903_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 5kkg ANCMT E72A
(synthetic
construct) 		4 / 6 TYR A  13
VAL A 216
ILE A 256
LEU A 260
 None
 1.29A 1j96A-5kkgA:
2.4		 1j96A-5kkgA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5kkg ANCMT E72A
(synthetic
construct) 		5 / 11 PHE A 129
ILE A 137
ALA A 151
LEU A 121
ALA A 126
 None
 1.33A 1jb0B-5kkgA:
undetectable		 1jb0B-5kkgA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5kkg ANCMT E72A
(synthetic
construct) 		4 / 6 ASN A  14
ASN A  16
ILE A 101
GLY A  96
 None
 0.93A 1oniA-5kkgA:
undetectable
1oniB-5kkgA:
undetectable		 1oniA-5kkgA:
15.85
1oniB-5kkgA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD508_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5kkg ANCMT E72A
(synthetic
construct) 		4 / 6 ASN A  14
ASN A  16
ILE A 101
GLY A  96
 None
 0.99A 1oniD-5kkgA:
undetectable
1oniF-5kkgA:
undetectable		 1oniD-5kkgA:
15.85
1oniF-5kkgA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_B_SAMB2401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 5kkg ANCMT E72A
(synthetic
construct) 		5 / 12 LEU A 106
GLY A  96
ILE A 102
LEU A 382
THR A 369
 None
 1.11A 1p91B-5kkgA:
3.1		 1p91B-5kkgA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5kkg ANCMT E72A
(synthetic
construct) 		5 / 10 LEU A 304
TYR A 301
GLY A 320
ALA A 321
LEU A 325
 None
 1.12A 1pxxA-5kkgA:
undetectable		 1pxxA-5kkgA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)		 5kkg ANCMT E72A
(synthetic
construct) 		5 / 10 VAL A 335
LEU A 296
GLY A 320
TYR A 340
ILE A 318
 None
 1.32A 1sq5D-5kkgA:
undetectable		 1sq5D-5kkgA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 5kkg ANCMT E72A
(synthetic
construct) 		5 / 11 SER A 312
VAL A 317
LEU A 342
LEU A 397
LEU A 417
 None
 1.17A 2a15A-5kkgA:
undetectable		 2a15A-5kkgA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 5kkg ANCMT E72A
(synthetic
construct) 		5 / 9 GLU A 361
LEU A 109
LEU A 382
HIS A   0
ALA A 368
 None
 1.44A 2bxcB-5kkgA:
1.4		 2bxcB-5kkgA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 5kkg ANCMT E72A
(synthetic
construct) 		5 / 12 LEU A 366
LEU A 109
LEU A 106
ALA A 103
ILE A 102
 None
 1.01A 2bxpA-5kkgA:
undetectable		 2bxpA-5kkgA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5kkg ANCMT E72A
(synthetic
construct) 		5 / 9 GLU A 319
ILE A 318
ILE A 344
GLU A 411
ILE A 415
 None
 1.18A 2j9dA-5kkgA:
undetectable
2j9dB-5kkgA:
undetectable
2j9dC-5kkgA:
undetectable		 2j9dA-5kkgA:
14.98
2j9dB-5kkgA:
14.98
2j9dC-5kkgA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_E_ACTE1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5kkg ANCMT E72A
(synthetic
construct) 		5 / 10 GLU A 319
ILE A 318
ILE A 344
GLU A 411
ILE A 415
 None
 1.17A 2j9dD-5kkgA:
undetectable
2j9dE-5kkgA:
undetectable
2j9dF-5kkgA:
undetectable		 2j9dD-5kkgA:
14.98
2j9dE-5kkgA:
14.98
2j9dF-5kkgA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_E_ACTE1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5kkg ANCMT E72A
(synthetic
construct) 		5 / 10 GLU A 411
ILE A 415
GLU A 319
ILE A 318
ILE A 344
 None
 1.20A 2j9dD-5kkgA:
undetectable
2j9dE-5kkgA:
undetectable
2j9dF-5kkgA:
undetectable		 2j9dD-5kkgA:
14.98
2j9dE-5kkgA:
14.98
2j9dF-5kkgA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_H_ACTH1113_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5kkg ANCMT E72A
(synthetic
construct) 		5 / 9 GLU A 319
ILE A 318
ILE A 344
GLU A 411
ILE A 415
 None
 1.17A 2j9dG-5kkgA:
undetectable
2j9dH-5kkgA:
undetectable
2j9dI-5kkgA:
undetectable		 2j9dG-5kkgA:
14.98
2j9dH-5kkgA:
14.98
2j9dI-5kkgA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_H_ACTH1113_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5kkg ANCMT E72A
(synthetic
construct) 		5 / 9 GLU A 411
ILE A 415
GLU A 319
ILE A 318
ILE A 344
 None
 1.17A 2j9dG-5kkgA:
undetectable
2j9dH-5kkgA:
undetectable
2j9dI-5kkgA:
undetectable		 2j9dG-5kkgA:
14.98
2j9dH-5kkgA:
14.98
2j9dI-5kkgA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 5kkg ANCMT E72A
(synthetic
construct) 		4 / 5 GLU A 168
PRO A 182
ILE A 180
GLY A 169
 None
 1.19A 2qeuA-5kkgA:
0.7
2qeuC-5kkgA:
undetectable		 2qeuA-5kkgA:
14.65
2qeuC-5kkgA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 5kkg ANCMT E72A
(synthetic
construct) 		4 / 7 ILE A 101
LEU A 366
LEU A 432
GLY A 431
 None
None
AMP  A 501 (-3.7A)
None
 0.97A 2qqcD-5kkgA:
undetectable
2qqcE-5kkgA:
undetectable		 2qqcD-5kkgA:
12.00
2qqcE-5kkgA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5kkg ANCMT E72A
(synthetic
construct) 		4 / 8 TYR A 224
TYR A  13
SER A 118
GLN A 225
 None
 1.17A 2xz5B-5kkgA:
undetectable
2xz5E-5kkgA:
undetectable		 2xz5B-5kkgA:
18.09
2xz5E-5kkgA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5kkg ANCMT E72A
(synthetic
construct) 		5 / 12 VAL A 317
GLY A 320
ALA A 321
LEU A 325
LEU A 330
 None
 0.95A 3hs6A-5kkgA:
undetectable		 3hs6A-5kkgA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_A_EPAA1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5kkg ANCMT E72A
(synthetic
construct) 		5 / 12 VAL A 332
GLY A 439
ALA A 440
SER A 443
LEU A 447
 None
 0.93A 3hs6A-5kkgA:
undetectable		 3hs6A-5kkgA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5kkg ANCMT E72A
(synthetic
construct) 		5 / 12 SER A 420
ILE A 436
GLY A 439
ALA A 440
SER A 443
 None
AMP  A 501 (-4.7A)
None
None
None
 1.08A 3kk6A-5kkgA:
1.4		 3kk6A-5kkgA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 5kkg ANCMT E72A
(synthetic
construct) 		5 / 12 VAL A  15
GLY A 100
LEU A 121
PRO A 119
TYR A 135
 None
 1.18A 3mecA-5kkgA:
undetectable		 3mecA-5kkgA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 5kkg ANCMT E72A
(synthetic
construct) 		4 / 5 ILE A 101
ARG A 186
GLU A  92
GLU A 165
 None
 1.30A 3ny4A-5kkgA:
undetectable		 3ny4A-5kkgA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5kkg ANCMT E72A
(synthetic
construct) 		5 / 11 PHE A 129
ILE A 137
ALA A 151
LEU A 121
ALA A 126
 None
 1.32A 3pcqB-5kkgA:
undetectable		 3pcqB-5kkgA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 5kkg ANCMT E72A
(synthetic
construct) 		5 / 10 LEU A 106
ILE A 101
GLY A 433
ILE A 436
ILE A 102
 None
None
AMP  A 501 (-3.2A)
AMP  A 501 (-4.7A)
None
 0.91A 3s43B-5kkgA:
undetectable		 3s43B-5kkgA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 5kkg ANCMT E72A
(synthetic
construct) 		3 / 3 ASN A  16
ASP A  18
ASN A 161
 None
 0.79A 4agaA-5kkgA:
undetectable		 4agaA-5kkgA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5kkg ANCMT E72A
(synthetic
construct) 		4 / 7 VAL A 333
ILE A 344
LEU A 397
LEU A 417
 None
 0.82A 4l1wA-5kkgA:
undetectable		 4l1wA-5kkgA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5kkg ANCMT E72A
(synthetic
construct) 		5 / 12 LEU A 109
LEU A 448
PHE A 441
GLY A 439
LEU A  11
 None
 1.26A 4retA-5kkgA:
2.5		 4retA-5kkgA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5kkg ANCMT E72A
(synthetic
construct) 		5 / 12 LEU A 304
TYR A 301
GLY A 320
ALA A 321
LEU A 325
 None
 1.10A 4rrxA-5kkgA:
undetectable		 4rrxA-5kkgA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5kkg ANCMT E72A
(synthetic
construct) 		5 / 12 LEU A 304
TYR A 301
GLY A 320
ALA A 321
LEU A 325
 None
 1.02A 4rrxB-5kkgA:
undetectable		 4rrxB-5kkgA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5kkg ANCMT E72A
(synthetic
construct) 		5 / 12 PHE A 129
ILE A 137
ALA A 151
LEU A 121
ALA A 126
 None
 1.29A 5oy02-5kkgA:
undetectable		 5oy02-5kkgA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 5kkg ANCMT E72A
(synthetic
construct) 		5 / 12 LEU A 106
ILE A 101
GLY A 433
ILE A 436
ILE A 102
 None
None
AMP  A 501 (-3.2A)
AMP  A 501 (-4.7A)
None
 0.92A 5t8hA-5kkgA:
undetectable		 5t8hA-5kkgA:
11.26