SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kkp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5kkp PSEUDOURIDYLATE
SYNTHASE 7
(Homo
sapiens) 		4 / 7 LEU A 448
ILE A 467
ALA A 463
ILE A 565
 None
 0.97A 1oniB-5kkpA:
undetectable
1oniC-5kkpA:
undetectable		 1oniB-5kkpA:
13.70
1oniC-5kkpA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 5kkp PSEUDOURIDYLATE
SYNTHASE 7
(Homo
sapiens) 		4 / 6 ALA A 635
PHE A 627
VAL A 139
PHE A 137
 None
 0.93A 2cizA-5kkpA:
undetectable		 2cizA-5kkpA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5kkp PSEUDOURIDYLATE
SYNTHASE 7
(Homo
sapiens) 		5 / 10 ILE A 476
GLY A 391
TYR A 475
PHE A 464
HIS A 563
 None
 1.03A 2y7pA-5kkpA:
undetectable		 2y7pA-5kkpA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5kkp PSEUDOURIDYLATE
SYNTHASE 7
(Homo
sapiens) 		5 / 12 PHE A 371
ILE A 372
ILE A 524
ARG A 491
VAL A 488
 None
 0.90A 3fpjB-5kkpA:
undetectable		 3fpjB-5kkpA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 5kkp PSEUDOURIDYLATE
SYNTHASE 7
(Homo
sapiens) 		5 / 12 PHE A 371
ILE A 372
VAL A 120
ARG A 491
VAL A 488
 None
 1.21A 3fpjB-5kkpA:
undetectable		 3fpjB-5kkpA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5kkp PSEUDOURIDYLATE
SYNTHASE 7
(Homo
sapiens) 		3 / 3 PHE A 345
TYR A 634
LEU A 623
 None
EDO  A 701 (-4.8A)
None
 0.79A 3sueB-5kkpA:
undetectable		 3sueB-5kkpA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J5J_B_478B401_2
(PROTEASE)		 5kkp PSEUDOURIDYLATE
SYNTHASE 7
(Homo
sapiens) 		5 / 10 ASN A 397
ILE A 394
GLY A 465
ILE A 466
VAL A 402
 None
 1.07A 4j5jB-5kkpA:
undetectable		 4j5jB-5kkpA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 5kkp PSEUDOURIDYLATE
SYNTHASE 7
(Homo
sapiens) 		5 / 12 ILE A 308
ALA A 272
HIS A 259
VAL A 305
ILE A 286
 None
 0.97A 4rvdA-5kkpA:
undetectable		 4rvdA-5kkpA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 5kkp PSEUDOURIDYLATE
SYNTHASE 7
(Homo
sapiens) 		5 / 11 LEU A 452
PHE A 464
ILE A 460
ASN A 459
VAL A 402
 None
 1.16A 5hjiA-5kkpA:
4.8		 5hjiA-5kkpA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 5kkp PSEUDOURIDYLATE
SYNTHASE 7
(Homo
sapiens) 		4 / 4 LEU A 531
MET A 487
ILE A 476
LEU A 551
 None
 1.28A 5nfpA-5kkpA:
undetectable		 5nfpA-5kkpA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 5kkp PSEUDOURIDYLATE
SYNTHASE 7
(Homo
sapiens) 		3 / 3 GLU A 445
LEU A 449
ARG A 450
 None
 0.66A 6d8fA-5kkpA:
undetectable		 6d8fA-5kkpA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 5kkp PSEUDOURIDYLATE
SYNTHASE 7
(Homo
sapiens) 		4 / 5 THR A 346
HIS A 140
ASP A 602
HIS A 150
 None
 1.32A 6dchA-5kkpA:
undetectable		 6dchA-5kkpA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 5kkp PSEUDOURIDYLATE
SYNTHASE 7
(Homo
sapiens) 		5 / 12 ASN A 471
GLU A 445
GLN A 447
PRO A 468
GLY A 465
 None
 1.35A 6gnfC-5kkpA:
undetectable		 6gnfC-5kkpA:
21.56