SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kku'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		3 / 3 SER A  69
GLU A  70
GLU A  71
 None
 0.59A 1eqbD-5kkuA:
undetectable		 1eqbD-5kkuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		3 / 3 SER A  69
GLU A  70
GLU A  71
 None
 0.58A 1eqbB-5kkuA:
undetectable		 1eqbB-5kkuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		4 / 6 HIS A  25
ASP A  40
THR A  37
HIS A 155
 None
 1.35A 2einA-5kkuA:
undetectable
2einC-5kkuA:
undetectable		 2einA-5kkuA:
20.16
2einC-5kkuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		4 / 6 HIS A  25
ASP A  40
THR A  37
HIS A 155
 None
 1.37A 2zxwN-5kkuA:
undetectable
2zxwP-5kkuA:
undetectable		 2zxwN-5kkuA:
20.16
2zxwP-5kkuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		5 / 12 ARG A 268
LEU A 177
ILE A 128
ILE A 144
ALA A 199
 None
 1.22A 3axtA-5kkuA:
undetectable		 3axtA-5kkuA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		4 / 5 ILE A 265
PHE A 263
ASP A 262
GLU A 277
 None
 1.06A 3kp6A-5kkuA:
undetectable
3kp6B-5kkuA:
undetectable		 3kp6A-5kkuA:
17.88
3kp6B-5kkuA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		4 / 7 THR A 201
ASP A 198
HIS A  25
ILE A 220
 None
 1.10A 3t01A-5kkuA:
undetectable		 3t01A-5kkuA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		4 / 6 LEU A  50
PRO A  82
GLN A   7
TYR A  49
 None
 1.36A 3vkxA-5kkuA:
undetectable		 3vkxA-5kkuA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		4 / 7 GLN A  13
PHE A  11
PHE A  80
LEU A 114
 None
 0.97A 3x2qP-5kkuA:
undetectable
3x2qW-5kkuA:
undetectable		 3x2qP-5kkuA:
20.12
3x2qW-5kkuA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C66_A_H4CA1168_0
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		5 / 9 PRO A  34
VAL A  66
ASN A  19
ILE A  21
MET A 159
 None
 1.24A 4c66A-5kkuA:
undetectable		 4c66A-5kkuA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		4 / 8 GLU A  90
THR A  81
LEU A  45
VAL A   8
 None
 0.89A 4ik6B-5kkuA:
undetectable		 4ik6B-5kkuA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		5 / 11 SER A 205
GLY A 204
LEU A 279
ILE A  91
LEU A  76
 None
 1.01A 4kt0A-5kkuA:
undetectable
4kt0J-5kkuA:
undetectable		 4kt0A-5kkuA:
16.93
4kt0J-5kkuA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		3 / 3 TYR A  77
THR A  79
THR A  92
 None
 0.60A 5aoxB-5kkuA:
undetectable		 5aoxB-5kkuA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		3 / 3 TYR A  77
THR A  10
THR A  92
 None
 0.83A 5aoxE-5kkuA:
undetectable		 5aoxE-5kkuA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		3 / 3 TYR A  77
THR A  79
THR A  92
 None
 0.62A 5aoxE-5kkuA:
undetectable		 5aoxE-5kkuA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		5 / 12 TYR A  43
ILE A  91
LEU A  76
THR A  37
GLY A  35
 None
 1.12A 5d4uA-5kkuA:
undetectable		 5d4uA-5kkuA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		5 / 12 TYR A  43
ILE A  91
LEU A  76
THR A  37
GLY A  35
 None
 1.12A 5d4uB-5kkuA:
undetectable		 5d4uB-5kkuA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		4 / 7 HIS A  25
ASP A  40
THR A  37
HIS A 155
 None
 1.36A 5iy5A-5kkuA:
undetectable
5iy5C-5kkuA:
undetectable		 5iy5A-5kkuA:
20.16
5iy5C-5kkuA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		4 / 6 TYR A 238
THR A 236
ASP A 267
GLY A 270
 None
 1.15A 5mraA-5kkuA:
undetectable
5mraB-5kkuA:
undetectable		 5mraA-5kkuA:
20.27
5mraB-5kkuA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		3 / 3 GLU A 118
TYR A 115
ARG A  58
 None
 0.77A 5uunA-5kkuA:
undetectable		 5uunA-5kkuA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		4 / 7 HIS A  25
ASP A  40
THR A  37
HIS A 155
 None
 1.38A 5x1fN-5kkuA:
undetectable
5x1fP-5kkuA:
undetectable		 5x1fN-5kkuA:
20.16
5x1fP-5kkuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		4 / 6 GLN A  13
PHE A  11
PHE A  80
LEU A 114
 None
 1.00A 5z84P-5kkuA:
undetectable
5z84W-5kkuA:
undetectable		 5z84P-5kkuA:
20.12
5z84W-5kkuA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		4 / 6 GLN A  13
PHE A  11
PHE A  80
LEU A 114
 None
 0.99A 5z85P-5kkuA:
undetectable
5z85W-5kkuA:
undetectable		 5z85P-5kkuA:
20.12
5z85W-5kkuA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		4 / 6 GLN A  13
PHE A  11
PHE A  80
LEU A 114
 None
 1.05A 5z86C-5kkuA:
undetectable
5z86J-5kkuA:
undetectable		 5z86C-5kkuA:
20.12
5z86J-5kkuA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		4 / 6 GLN A  13
PHE A  11
PHE A  80
LEU A 114
 None
 0.99A 5z86P-5kkuA:
undetectable
5z86W-5kkuA:
undetectable		 5z86P-5kkuA:
20.12
5z86W-5kkuA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		4 / 6 GLN A  13
PHE A  11
PHE A  80
LEU A 114
 None
 0.98A 5zcoP-5kkuA:
undetectable
5zcoW-5kkuA:
undetectable		 5zcoP-5kkuA:
20.12
5zcoW-5kkuA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		4 / 6 GLN A  13
PHE A  11
PHE A  80
LEU A 114
 None
 1.03A 5zcpC-5kkuA:
undetectable
5zcpJ-5kkuA:
undetectable		 5zcpC-5kkuA:
20.12
5zcpJ-5kkuA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		4 / 6 GLN A  13
PHE A  11
PHE A  80
LEU A 114
 None
 1.02A 5zcpP-5kkuA:
undetectable
5zcpW-5kkuA:
undetectable		 5zcpP-5kkuA:
20.12
5zcpW-5kkuA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 5kku POLYKETIDE SYNTHASE
TYPE I
(Bacillus
amyloliquefacien
s) 		5 / 11 PHE A 196
LEU A 179
LEU A 197
ARG A 187
MET A 229
 None
 1.41A 6fgcA-5kkuA:
undetectable		 6fgcA-5kkuA:
15.20