SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5klh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3I45_A_NIOA500_1 (TWIN-ARGININE TRANSLOCATION PATHWAY SIGNAL PROTEIN)	5klh	SURFACE GLYCOPROTEIN (Trypanosoma brucei)	4 / 8	SER A 212 GLU A 247 LEU A 214 TYR A 193	None	0.86A	3i45A-5klhA: undetectable	3i45A-5klhA: 19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SMT_A_ACTA500_0 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD3)	5klh	SURFACE GLYCOPROTEIN (Trypanosoma brucei)	3 / 3	PHE A 133 SER A 136 GLN A 139	None	1.00A	3smtA-5klhA: undetectable	3smtA-5klhA: 19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VLN_A_ASCA904_0 (GLUTATHIONE S-TRANSFERASE OMEGA-1)	5klh	SURFACE GLYCOPROTEIN (Trypanosoma brucei)	4 / 6	PHE A 243 LEU A 246 PRO A 242 SER A 89	None	1.09A	3vlnA-5klhA: undetectable	3vlnA-5klhA: 22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZMQ_I_PACI1_0 (SERINE PROTEASE NS3 SERINE PROTEASE SUBUNIT NS2B PEPTIDE PAC-DLY-DLY-DAR)	5klh	SURFACE GLYCOPROTEIN (Trypanosoma brucei)	3 / 3	VAL A 90 TYR A 91 GLU A 61	None	0.98A	5zmqD-5klhA: undetectable 5zmqE-5klhA: undetectable	5zmqD-5klhA: 23.05 5zmqE-5klhA: 13.33

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3I45_A_NIOA500_1","TWIN-ARGININE TRANSLOCATION PATHWAY SIGNAL PROTEIN","5klh","SURFACE GLYCOPROTEIN","Trypanosoma brucei",4,"SER A 212;GLU A 247;LEU A 214;TYR A 193","None","0.86A","3i45A-5klhA:undetectable","3i45A-5klhA:19.02"],["3SMT_A_ACTA500_0","HISTONE-LYSINE N-METHYLTRANSFERASE SETD3","5klh","SURFACE GLYCOPROTEIN","Trypanosoma brucei",3,"PHE A 133;SER A 136;GLN A 139","None","1.00A","3smtA-5klhA:undetectable","3smtA-5klhA:19.28"],["3VLN_A_ASCA904_0","GLUTATHIONE S-TRANSFERASE OMEGA-1","5klh","SURFACE GLYCOPROTEIN","Trypanosoma brucei",4,"PHE A 243;LEU A 246;PRO A 242;SER A  89","None","1.09A","3vlnA-5klhA:undetectable","3vlnA-5klhA:22.48"],["5ZMQ_I_PACI1_0","SERINE PROTEASE NS3;SERINE PROTEASE SUBUNIT NS2B;PEPTIDE PAC-DLY-DLY-DAR","5klh","SURFACE GLYCOPROTEIN","Trypanosoma brucei",3,"VAL A  90;TYR A  91;GLU A  61","None","0.98A","5zmqD-5klhA:undetectable;5zmqE-5klhA:undetectable","5zmqD-5klhA:23.05;5zmqE-5klhA:13.33"]]