SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kn5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 5kn5 EPIREGULIN ANTIBODY
LY3016859 FAB HEAVY
CHAIN
(Homo
sapiens) 		4 / 4 ALA A  40
ARG A  38
GLN A  43
GLU A  46
 None
 0.76A 1lqtB-5kn5A:
undetectable		 1lqtB-5kn5A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 5kn5 EPIREGULIN ANTIBODY
LY3016859 FAB HEAVY
CHAIN
(Homo
sapiens) 		4 / 4 ALA A  40
ARG A  38
GLN A  43
GLU A  46
 None
 0.78A 1lquB-5kn5A:
undetectable		 1lquB-5kn5A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5kn5 EPIREGULIN ANTIBODY
LY3016859 FAB HEAVY
CHAIN
PROTRANSFORMING
GROWTH FACTOR ALPHA
(Homo
sapiens;
Homo
sapiens) 		4 / 7 ARG C  22
ALA C  31
ILE A  57
PRO A  55
 None
 0.89A 1oniA-5kn5C:
undetectable
1oniB-5kn5C:
undetectable		 1oniA-5kn5C:
11.59
1oniB-5kn5C:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5kn5 EPIREGULIN ANTIBODY
LY3016859 FAB HEAVY
CHAIN
PROTRANSFORMING
GROWTH FACTOR ALPHA
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ARG C  22
ALA C  31
ILE A  57
PRO A  55
 None
 0.90A 1oniB-5kn5C:
undetectable
1oniC-5kn5C:
undetectable		 1oniB-5kn5C:
11.59
1oniC-5kn5C:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_E_BEZE509_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5kn5 EPIREGULIN ANTIBODY
LY3016859 FAB HEAVY
CHAIN
PROTRANSFORMING
GROWTH FACTOR ALPHA
(Homo
sapiens;
Homo
sapiens) 		4 / 7 ILE A  57
PRO A  55
ARG C  22
ALA C  31
 None
 0.92A 1oniD-5kn5A:
undetectable
1oniE-5kn5A:
undetectable		 1oniD-5kn5A:
24.06
1oniE-5kn5A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5kn5 EPIREGULIN ANTIBODY
LY3016859 FAB HEAVY
CHAIN
PROTRANSFORMING
GROWTH FACTOR ALPHA
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ARG C  22
ALA C  31
ILE A  57
PRO A  55
 None
 0.97A 1oniH-5kn5C:
undetectable
1oniI-5kn5C:
undetectable		 1oniH-5kn5C:
11.59
1oniI-5kn5C:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5kn5 EPIREGULIN ANTIBODY
LY3016859 FAB HEAVY
CHAIN
PROTRANSFORMING
GROWTH FACTOR ALPHA
(Homo
sapiens;
Homo
sapiens) 		4 / 7 ILE A  57
PRO A  55
ARG C  22
ALA C  31
 None
 0.86A 1oniG-5kn5A:
undetectable
1oniI-5kn5A:
undetectable		 1oniG-5kn5A:
24.06
1oniI-5kn5A:
24.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 5kn5 EPIREGULIN ANTIBODY
LY3016859 FAB HEAVY
CHAIN
(Homo
sapiens) 		3 / 3 TRP A  47
ARG A  99
PHE A 105
 None
 1.20A 1zeaH-5kn5A:
21.5
1zeaL-5kn5A:
17.4		 1zeaH-5kn5A:
59.63
1zeaL-5kn5A:
26.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 5kn5 EPIREGULIN ANTIBODY
LY3016859 FAB HEAVY
CHAIN
(Homo
sapiens) 		4 / 5 VAL A   2
TYR A  27
ARG A  98
TYR A 107
 SO4  A 301 (-3.9A)
None
None
SO4  A 301 (-4.1A)
 0.22A 4m7kH-5kn5A:
22.7		 4m7kH-5kn5A:
77.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5kn5 EPIREGULIN ANTIBODY
LY3016859 FAB HEAVY
CHAIN
(Homo
sapiens) 		4 / 7 ALA A  92
THR A  91
VAL A 114
GLU A  89
 None
 0.74A 5ecmD-5kn5A:
undetectable		 5ecmD-5kn5A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5kn5 EPIREGULIN ANTIBODY
LY3016859 FAB HEAVY
CHAIN
(Homo
sapiens) 		4 / 7 ALA A  92
THR A  91
VAL A 114
GLU A  89
 None
 0.79A 5ecoD-5kn5A:
undetectable		 5ecoD-5kn5A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 5kn5 EPIREGULIN ANTIBODY
LY3016859 FAB HEAVY
CHAIN
(Homo
sapiens) 		4 / 4 VAL A 126
LEU A 129
ASN A 202
ASP A 213
 None
 1.30A 5vcyA-5kn5A:
undetectable		 5vcyA-5kn5A:
20.50