SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kn7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)
5kn7 LIPID A BIOSYNTHESIS
LAUROYL
ACYLTRANSFERASE

(Acinetobacter
baumannii)
5 / 9 LEU B 118
LEU B 227
ILE B 219
THR B 140
ILE B 177
None
1.48A 1hzeA-5kn7B:
undetectable
1hzeB-5kn7B:
undetectable
1hzeA-5kn7B:
17.47
1hzeB-5kn7B:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)
5kn7 LIPID A BIOSYNTHESIS
LAUROYL
ACYLTRANSFERASE

(Acinetobacter
baumannii)
5 / 9 THR B 140
ILE B 177
LEU B 118
LEU B 227
ILE B 219
None
1.48A 1hzeA-5kn7B:
undetectable
1hzeB-5kn7B:
undetectable
1hzeA-5kn7B:
17.47
1hzeB-5kn7B:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)
5kn7 LIPID A BIOSYNTHESIS
LAUROYL
ACYLTRANSFERASE

(Acinetobacter
baumannii)
3 / 3 TRP B  86
PHE B  82
TRP B 126
None
None
GOL  B 409 (-4.6A)
1.48A 1r15C-5kn7B:
undetectable
1r15C-5kn7B:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)
5kn7 LIPID A BIOSYNTHESIS
LAUROYL
ACYLTRANSFERASE

(Acinetobacter
baumannii)
3 / 3 TRP B  86
PHE B  82
TRP B 126
None
None
GOL  B 409 (-4.6A)
1.47A 1r15F-5kn7B:
undetectable
1r15F-5kn7B:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)
5kn7 LIPID A BIOSYNTHESIS
LAUROYL
ACYLTRANSFERASE

(Acinetobacter
baumannii)
3 / 3 TRP B  86
PHE B  82
TRP B 126
None
None
GOL  B 409 (-4.6A)
1.48A 1r15G-5kn7B:
undetectable
1r15G-5kn7B:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)
5kn7 LIPID A BIOSYNTHESIS
LAUROYL
ACYLTRANSFERASE

(Acinetobacter
baumannii)
3 / 3 TRP B  86
PHE B  82
TRP B 126
None
None
GOL  B 409 (-4.6A)
1.47A 1r15H-5kn7B:
undetectable
1r15H-5kn7B:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)
5kn7 LIPID A BIOSYNTHESIS
LAUROYL
ACYLTRANSFERASE

(Acinetobacter
baumannii)
4 / 6 ALA B 131
ALA B 134
THR B 137
PHE B 106
None
0.98A 2xfhA-5kn7B:
undetectable
2xfhA-5kn7B:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
5kn7 LIPID A BIOSYNTHESIS
LAUROYL
ACYLTRANSFERASE

(Acinetobacter
baumannii)
3 / 3 ASN B  74
MET B 129
PHE B 123
None
1.10A 3g4lD-5kn7B:
undetectable
3g4lD-5kn7B:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)
5kn7 LIPID A BIOSYNTHESIS
LAUROYL
ACYLTRANSFERASE

(Acinetobacter
baumannii)
4 / 7 VAL B 116
LEU B 229
MET B 241
ILE B 243
None
1.02A 3rfmA-5kn7B:
undetectable
3rfmA-5kn7B:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD9_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)
5kn7 LIPID A BIOSYNTHESIS
LAUROYL
ACYLTRANSFERASE

(Acinetobacter
baumannii)
4 / 7 VAL B 116
PHE B 106
HIS B 107
GLU B 108
None
1.33A 5ad9A-5kn7B:
undetectable
5ad9B-5kn7B:
undetectable
5ad9A-5kn7B:
22.48
5ad9B-5kn7B:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)
5kn7 LIPID A BIOSYNTHESIS
LAUROYL
ACYLTRANSFERASE

(Acinetobacter
baumannii)
4 / 8 PRO B 121
PHE B 123
TRP B 126
TYR B  79
None
None
GOL  B 409 (-4.6A)
LMT  B 415 (-3.8A)
1.32A 5amkA-5kn7B:
undetectable
5amkA-5kn7B:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D6T_D_FYPD406_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
HUMAN GABA-A
RECEPTOR SUBUNIT
GAMMA-2)
5kn7 LIPID A BIOSYNTHESIS
LAUROYL
ACYLTRANSFERASE

(Acinetobacter
baumannii)
5 / 11 TYR B 294
THR B 194
TYR B 281
TYR B 204
PHE B 284
None
None
GOL  B 414 (-4.6A)
None
None
1.42A 6d6tD-5kn7B:
undetectable
6d6tE-5kn7B:
undetectable
6d6tD-5kn7B:
21.57
6d6tE-5kn7B:
18.66