SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5knm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 5knm LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 1
(Homo
sapiens) 		5 / 12 HIS D  69
TRP D  46
ILE D  65
ILE D  62
TYR D  73
 None
 1.45A 2efjA-5knmD:
undetectable		 2efjA-5knmD:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 5knm CDNA FLJ39643 FIS,
CLONE SMINT2004023,
HIGHLY SIMILAR TO
HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, ALPHACHAIN
F
BETA-2-MICROGLOBULIN
(Homo
sapiens;
Homo
sapiens) 		4 / 6 ARG A  21
THR A  94
ALA A  11
PRO B  32
 None
 1.27A 2ql8A-5knmA:
undetectable
2ql8B-5knmA:
undetectable		 2ql8A-5knmA:
18.69
2ql8B-5knmA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5knm LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 1
(Homo
sapiens) 		4 / 7 ARG D 173
VAL D  15
ILE D  16
TYR D 175
 None
 1.15A 2yfbA-5knmD:
undetectable		 2yfbA-5knmD:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5knm LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 1
(Homo
sapiens) 		4 / 6 ARG D 173
VAL D  15
ILE D  16
TYR D 175
 None
 1.11A 2yfbB-5knmD:
undetectable		 2yfbB-5knmD:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 5knm LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 1
(Homo
sapiens) 		5 / 12 GLY D  97
SER D 189
VAL D  15
ALA D 176
SER D 124
 None
 1.16A 3d91B-5knmD:
undetectable		 3d91B-5knmD:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5knm CDNA FLJ39643 FIS,
CLONE SMINT2004023,
HIGHLY SIMILAR TO
HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, ALPHACHAIN
F
LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 1
(Homo
sapiens;
Homo
sapiens) 		3 / 3 SER D  87
ASP D  89
ASP A 196
 None
 0.79A 3iv6A-5knmD:
undetectable		 3iv6A-5knmD:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5knm CDNA FLJ39643 FIS,
CLONE SMINT2004023,
HIGHLY SIMILAR TO
HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, ALPHACHAIN
F
LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 1
(Homo
sapiens;
Homo
sapiens) 		3 / 3 SER D  87
ASP D  89
ASP A 196
 None
 0.73A 3iv6C-5knmD:
undetectable		 3iv6C-5knmD:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5knm CDNA FLJ39643 FIS,
CLONE SMINT2004023,
HIGHLY SIMILAR TO
HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, ALPHACHAIN
F
(Homo
sapiens) 		4 / 8 ASN A  70
THR A  73
HIS A 116
ASN A  99
 None
 1.11A 3kp2A-5knmA:
undetectable
3kp2B-5knmA:
undetectable		 3kp2A-5knmA:
20.07
3kp2B-5knmA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 5knm LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 1
(Homo
sapiens) 		5 / 12 GLY D  71
ALA D  70
ILE D  62
ALA D  44
ILE D  65
 None
 1.15A 3n3iA-5knmD:
undetectable		 3n3iA-5knmD:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_C_T1CC392_1
(TETX2 PROTEIN)		 5knm LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 1
(Homo
sapiens) 		5 / 11 ASN D 146
ASN D 180
GLY D 130
SER D 132
GLY D  71
 None
 0.90A 4a6nC-5knmD:
undetectable		 4a6nC-5knmD:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC391_1
(TETX2 PROTEIN)		 5knm LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 1
(Homo
sapiens) 		5 / 11 ASN D 146
ASN D 180
GLY D 130
SER D 132
GLY D  71
 None
 0.92A 4a99C-5knmD:
undetectable		 4a99C-5knmD:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5knm CDNA FLJ39643 FIS,
CLONE SMINT2004023,
HIGHLY SIMILAR TO
HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, ALPHACHAIN
F
LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 1
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ARG D  84
HIS A 197
TYR D  76
 None
 1.27A 4fu8A-5knmD:
undetectable		 4fu8A-5knmD:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5knm CDNA FLJ39643 FIS,
CLONE SMINT2004023,
HIGHLY SIMILAR TO
HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, ALPHACHAIN
F
LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 1
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ARG D  84
HIS A 197
TYR D  76
 None
 1.25A 4fu9A-5knmD:
undetectable		 4fu9A-5knmD:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_1
(MEMBRANE LIPOPROTEIN
TPN38(B))		 5knm LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 1
(Homo
sapiens) 		5 / 12 ALA D 176
ASP D 123
GLN D 121
ILE D 158
GLY D 153
 None
 1.34A 4iilA-5knmD:
undetectable		 4iilA-5knmD:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 5knm CDNA FLJ39643 FIS,
CLONE SMINT2004023,
HIGHLY SIMILAR TO
HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, ALPHACHAIN
F
(Homo
sapiens) 		3 / 3 LEU A   5
MET A  98
TYR A 159
 None
 0.73A 4p6xG-5knmA:
undetectable		 4p6xG-5knmA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 5knm BETA-2-MICROGLOBULIN
CDNA FLJ39643 FIS,
CLONE SMINT2004023,
HIGHLY SIMILAR TO
HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, ALPHACHAIN
F
(Homo
sapiens) 		5 / 12 SER B  20
HIS B  13
PHE B  22
ASP A 238
GLY A 237
 None
 1.26A 5eenA-5knmB:
undetectable		 5eenA-5knmB:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5knm CDNA FLJ39643 FIS,
CLONE SMINT2004023,
HIGHLY SIMILAR TO
HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, ALPHACHAIN
F
BETA-2-MICROGLOBULIN
(Homo
sapiens;
Homo
sapiens) 		5 / 12 TYR B  66
VAL B  82
ILE A  23
SER B  61
ILE B  35
 None
 1.07A 5hbsA-5knmB:
undetectable		 5hbsA-5knmB:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5knm CDNA FLJ39643 FIS,
CLONE SMINT2004023,
HIGHLY SIMILAR TO
HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, ALPHACHAIN
F
BETA-2-MICROGLOBULIN
(Homo
sapiens;
Homo
sapiens) 		4 / 6 GLU A  49
ARG A  48
ASP B  53
ASP A 238
 None
 1.24A 5zw4A-5knmA:
undetectable		 5zw4A-5knmA:
19.46