SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5knn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 9 VAL A 323
ALA A  78
THR A 304
ILE A 327
THR A  31
 None
 1.34A 1gtnL-5knnA:
undetectable
1gtnM-5knnA:
undetectable		 1gtnL-5knnA:
10.49
1gtnM-5knnA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 ARG A 326
ASP A 300
ASN A 257
 None
 0.80A 1nbhA-5knnA:
undetectable		 1nbhA-5knnA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 ARG A 326
ASP A 300
ASN A 257
 None
 0.78A 1nbhD-5knnA:
undetectable		 1nbhD-5knnA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 ASP A 208
ASP A 193
ALA A 200
LEU A 203
 None
 1.01A 1nh8A-5knnA:
undetectable		 1nh8A-5knnA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QYX_A_ASDA500_1
(ESTRADIOL 17
BETA-DEHYDROGENASE 1)		 5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 9 LEU A 427
PRO A 421
TYR A 334
HIS A 301
VAL A 297
 None
 1.39A 1qyxA-5knnA:
0.7		 1qyxA-5knnA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 6 ASP A 359
PHE A 361
THR A  72
GLU A  99
 None
 1.18A 2dttB-5knnA:
undetectable
2dttC-5knnA:
undetectable		 2dttB-5knnA:
15.16
2dttC-5knnA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 GLY A 319
PHE A  97
PHE A  41
GLY A  79
 None
 0.78A 3ko0M-5knnA:
undetectable
3ko0P-5knnA:
undetectable		 3ko0M-5knnA:
13.11
3ko0P-5knnA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 8 GLY A 319
PHE A  97
PHE A  41
GLY A  79
 None
 0.77A 3ko0O-5knnA:
undetectable
3ko0Q-5knnA:
undetectable		 3ko0O-5knnA:
13.11
3ko0Q-5knnA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP201_1
(PROTEIN S100-A4)		 5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 7 PHE A  41
GLY A  79
GLY A 319
PHE A  97
 None
 0.80A 3ko0M-5knnA:
undetectable
3ko0P-5knnA:
undetectable		 3ko0M-5knnA:
13.11
3ko0P-5knnA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)		 5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 PHE A 126
LEU A 101
GLY A 243
VAL A 250
 None
None
A5A  A 500 (-3.4A)
None
 1.08A 3wrkD-5knnA:
undetectable		 3wrkD-5knnA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 LEU A 349
VAL A 353
SER A 356
PHE A 263
VAL A  88
 None
 1.23A 4ib4A-5knnA:
undetectable		 4ib4A-5knnA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 ARG A  68
HIS A  23
SER A  67
 None
 0.88A 4mjwA-5knnA:
undetectable
4mjwB-5knnA:
0.3		 4mjwA-5knnA:
20.00
4mjwB-5knnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 SER A  67
ARG A  68
HIS A  23
 None
 0.92A 4mjwA-5knnA:
undetectable
4mjwB-5knnA:
undetectable		 4mjwA-5knnA:
20.00
4mjwB-5knnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 ARG A 326
GLU A 442
TYR A 322
 None
 0.94A 4r29D-5knnA:
undetectable		 4r29D-5knnA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		 5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 GLY A 321
ASP A 316
ARG A 325
MET A 370
 None
 1.06A 5gwkA-5knnA:
undetectable		 5gwkA-5knnA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		5 / 12 LEU A  39
GLY A 182
ALA A  44
ASN A  47
ASN A  43
 None
None
A5A  A 500 (-3.6A)
None
None
 1.06A 5kbwA-5knnA:
3.3		 5kbwA-5knnA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 ASP A 173
ASN A 205
ASP A 207
 None
 0.80A 5vopA-5knnA:
undetectable		 5vopA-5knnA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		3 / 3 ASP A 173
ASN A 205
ASP A 207
 None
 0.80A 5vopB-5knnA:
undetectable		 5vopB-5knnA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 THR A   6
ASP A 359
GLU A  99
ASN A  71
 None
 1.37A 5ybbA-5knnA:
1.5		 5ybbA-5knnA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		6 / 10 ARG A  77
HIS A  94
PHE A  98
GLU A 213
GLY A 243
ARG A 246
 A5A  A 500 (-2.8A)
A5A  A 500 (-4.5A)
A5A  A 500 (-3.4A)
A5A  A 500 (-3.8A)
A5A  A 500 (-3.4A)
A5A  A 500 (-3.9A)
 0.63A 6bniA-5knnA:
11.6		 6bniA-5knnA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		6 / 10 ARG A  77
HIS A  94
PHE A  98
GLU A 213
GLY A 243
ARG A 246
 A5A  A 500 (-2.8A)
A5A  A 500 (-4.5A)
A5A  A 500 (-3.4A)
A5A  A 500 (-3.8A)
A5A  A 500 (-3.4A)
A5A  A 500 (-3.9A)
 0.62A 6bniB-5knnA:
11.8		 6bniB-5knnA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GH9_A_MIXA1003_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens) 		4 / 5 ASN A  83
TYR A 322
GLY A 321
ASP A 423
 None
 1.26A 6gh9A-5knnA:
undetectable		 6gh9A-5knnA:
10.89