SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ko3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5ko3 ORF1A
(Middle
East
respiratory
syndrome-related
coronavirus) 		5 / 12 VAL A  90
LEU A  86
PHE A  83
LEU A  80
TYR A  72
 None
None
ACT  A 402 ( 4.7A)
None
None
 1.32A 1mmkA-5ko3A:
undetectable		 1mmkA-5ko3A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 5ko3 ORF1A
(Middle
East
respiratory
syndrome-related
coronavirus) 		5 / 11 ILE A 289
THR A 257
LEU A 284
VAL A 268
PHE A 263
 None
 1.34A 1tw4A-5ko3A:
undetectable		 1tw4A-5ko3A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 5ko3 ORF1A
(Middle
East
respiratory
syndrome-related
coronavirus) 		5 / 11 MET A 185
LEU A 218
SER A 247
LEU A 246
ASP A 309
 None
 1.25A 2c12F-5ko3A:
undetectable		 2c12F-5ko3A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 5ko3 ORF1A
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 5 LEU A  80
VAL A 116
LEU A 120
ARG A 168
 None
 1.06A 2oiqA-5ko3A:
undetectable		 2oiqA-5ko3A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5ko3 ORF1A
(Middle
East
respiratory
syndrome-related
coronavirus) 		5 / 12 LEU A 133
PHE A 128
LEU A 151
VAL A  90
VAL A 116
 None
None
ACT  A 405 ( 4.5A)
None
None
 1.34A 2pnjB-5ko3A:
undetectable		 2pnjB-5ko3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5ko3 ORF1A
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 8 LEU A 201
LEU A 244
VAL A 212
GLY A 211
 None
 0.99A 2po5A-5ko3A:
undetectable		 2po5A-5ko3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5ko3 ORF1A
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 8 ASP A 309
LEU A 174
LEU A 245
CYH A 208
 None
 0.64A 3lm8A-5ko3A:
undetectable
3lm8C-5ko3A:
undetectable		 3lm8A-5ko3A:
19.93
3lm8C-5ko3A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5ko3 ORF1A
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 8 ASP A 309
LEU A 174
LEU A 245
CYH A 208
 None
 0.83A 3lm8B-5ko3A:
undetectable
3lm8D-5ko3A:
undetectable		 3lm8B-5ko3A:
19.93
3lm8D-5ko3A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK6_B_LURB201_1
(TRANSTHYRETIN)		 5ko3 ORF1A
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 8 LYS A 291
ALA A 282
LEU A 284
VAL A 268
 ACT  A 406 (-2.9A)
None
None
None
 0.96A 4ik6B-5ko3A:
undetectable		 4ik6B-5ko3A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5ko3 ORF1A
(Middle
East
respiratory
syndrome-related
coronavirus) 		5 / 11 LEU A 133
PHE A 128
LEU A 151
VAL A  90
VAL A 116
 None
None
ACT  A 405 ( 4.5A)
None
None
 1.29A 4mk4B-5ko3A:
undetectable		 4mk4B-5ko3A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 5ko3 ORF1A
(Middle
East
respiratory
syndrome-related
coronavirus) 		5 / 12 THR A 159
GLY A 161
ASN A 109
ASP A 164
SER A  85
 None
None
CME  A 111 ( 3.9A)
None
None
 1.36A 4pooB-5ko3A:
undetectable		 4pooB-5ko3A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 5ko3 ORF1A
(Middle
East
respiratory
syndrome-related
coronavirus) 		5 / 10 ALA A 136
ASP A 144
LEU A 151
ALA A 150
LYS A  87
 ACT  A 405 ( 3.6A)
None
ACT  A 405 ( 4.5A)
None
ACT  A 402 (-2.6A)
 1.21A 4zbrA-5ko3A:
undetectable		 4zbrA-5ko3A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5ko3 ORF1A
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 7 PHE A 269
SER A 167
ALA A 166
PRO A 250
 None
 1.14A 5dzkD-5ko3A:
undetectable
5dzkR-5ko3A:
undetectable		 5dzkD-5ko3A:
21.01
5dzkR-5ko3A:
1.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5ko3 ORF1A
(Middle
East
respiratory
syndrome-related
coronavirus) 		4 / 6 PHE A 263
VAL A 310
ALA A 265
THR A 119
 None
 0.86A 5t7bA-5ko3A:
2.5		 5t7bA-5ko3A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_G_CHDG401_0
(BILE SALT HYDROLASE)		 5ko3 ORF1A
(Middle
East
respiratory
syndrome-related
coronavirus) 		5 / 10 LEU A  68
TYR A  72
ILE A 130
LEU A 151
LEU A  86
 None
None
None
ACT  A 405 ( 4.5A)
None
 1.21A 5y7pG-5ko3A:
undetectable		 5y7pG-5ko3A:
20.49