SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ko5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 8 SER A 241
ILE A 243
GLY A  34
ARG A  86
 None
None
EDO  A 302 (-3.4A)
EDO  A 302 (-4.3A)
 0.97A 1meiA-5ko5A:
undetectable		 1meiA-5ko5A:
20.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 10 GLU A 203
VAL A 219
GLY A 220
MET A 221
HIS A 259
 CYT  A 301 (-2.9A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
None
 0.90A 1pwyE-5ko5A:
39.6		 1pwyE-5ko5A:
46.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 10 GLY A 120
VAL A 219
GLY A 220
MET A 221
ASN A 245
 CYT  A 301 (-3.3A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
CYT  A 301 (-3.2A)
 0.54A 1pwyE-5ko5A:
39.6		 1pwyE-5ko5A:
46.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 10 GLY A 120
VAL A 219
GLY A 220
MET A 221
HIS A 259
 CYT  A 301 (-3.3A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
None
 0.59A 1pwyE-5ko5A:
39.6		 1pwyE-5ko5A:
46.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 10 GLU A 203
VAL A 219
GLY A 220
MET A 221
HIS A 259
 CYT  A 301 (-2.9A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
None
 0.89A 1v3qE-5ko5A:
40.4		 1v3qE-5ko5A:
46.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 10 GLY A 120
VAL A 219
GLY A 220
MET A 221
ASN A 245
 CYT  A 301 (-3.3A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
CYT  A 301 (-3.2A)
 0.41A 1v3qE-5ko5A:
40.4		 1v3qE-5ko5A:
46.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 10 GLY A 120
VAL A 219
GLY A 220
MET A 221
HIS A 259
 CYT  A 301 (-3.3A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
None
 0.36A 1v3qE-5ko5A:
40.4		 1v3qE-5ko5A:
46.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 7 GLY A 120
GLY A 121
ASP A 250
VAL A 262
 CYT  A 301 (-3.3A)
None
None
None
 0.77A 2oa1B-5ko5A:
undetectable		 2oa1B-5ko5A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		3 / 3 ASP A 130
PHE A 131
LEU A 133
 None
 0.68A 2zi9A-5ko5A:
undetectable		 2zi9A-5ko5A:
20.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		6 / 6 GLY A 120
TYR A 202
GLU A 203
GLY A 220
MET A 221
ASN A 245
 CYT  A 301 (-3.3A)
CYT  A 301 (-4.6A)
CYT  A 301 (-2.9A)
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
CYT  A 301 (-3.2A)
 1.06A 3e9rA-5ko5A:
43.9		 3e9rA-5ko5A:
62.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		6 / 6 GLY A 120
TYR A 202
GLU A 203
GLY A 220
MET A 221
ASN A 245
 CYT  A 301 (-3.3A)
CYT  A 301 (-4.6A)
CYT  A 301 (-2.9A)
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
CYT  A 301 (-3.2A)
 1.02A 3e9rC-5ko5A:
44.4		 3e9rC-5ko5A:
62.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		8 / 12 GLY A 120
TYR A 202
GLU A 203
VAL A 219
GLY A 220
MET A 221
ASN A 245
VAL A 262
 CYT  A 301 (-3.3A)
CYT  A 301 (-4.6A)
CYT  A 301 (-2.9A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
CYT  A 301 (-3.2A)
None
 1.05A 3f8wA-5ko5A:
44.1		 3f8wA-5ko5A:
62.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		10 / 12 SER A  35
TYR A  90
GLY A 120
TYR A 202
GLU A 203
VAL A 219
GLY A 220
MET A 221
HIS A 259
VAL A 262
 EDO  A 302 (-3.6A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.6A)
CYT  A 301 (-2.9A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
None
None
 0.92A 3f8wA-5ko5A:
44.1		 3f8wA-5ko5A:
62.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		8 / 12 GLY A 120
TYR A 202
VAL A 219
GLY A 220
MET A 221
ASN A 245
HIS A 259
VAL A 262
 CYT  A 301 (-3.3A)
CYT  A 301 (-4.6A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
CYT  A 301 (-3.2A)
None
None
 0.61A 3f8wB-5ko5A:
43.8		 3f8wB-5ko5A:
62.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		10 / 12 SER A  35
HIS A  88
TYR A  90
GLY A 120
TYR A 202
VAL A 219
GLY A 220
MET A 221
HIS A 259
VAL A 262
 EDO  A 302 (-3.6A)
EDO  A 302 (-4.5A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.6A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
None
None
 0.56A 3f8wB-5ko5A:
43.8		 3f8wB-5ko5A:
62.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		10 / 12 SER A  35
HIS A  88
TYR A  90
TYR A 202
GLU A 203
VAL A 219
GLY A 220
MET A 221
HIS A 259
VAL A 262
 EDO  A 302 (-3.6A)
EDO  A 302 (-4.5A)
None
CYT  A 301 (-4.6A)
CYT  A 301 (-2.9A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
None
None
 0.90A 3f8wB-5ko5A:
43.8		 3f8wB-5ko5A:
62.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		8 / 12 TYR A 202
GLU A 203
VAL A 219
GLY A 220
MET A 221
ASN A 245
HIS A 259
VAL A 262
 CYT  A 301 (-4.6A)
CYT  A 301 (-2.9A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
CYT  A 301 (-3.2A)
None
None
 1.02A 3f8wB-5ko5A:
43.8		 3f8wB-5ko5A:
62.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		7 / 12 GLY A 120
TYR A 202
VAL A 219
GLY A 220
MET A 221
ASN A 245
VAL A 262
 CYT  A 301 (-3.3A)
CYT  A 301 (-4.6A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
CYT  A 301 (-3.2A)
None
 0.64A 3f8wC-5ko5A:
44.1		 3f8wC-5ko5A:
62.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		9 / 12 SER A  35
HIS A  88
TYR A  90
GLY A 120
TYR A 202
VAL A 219
GLY A 220
MET A 221
VAL A 262
 EDO  A 302 (-3.6A)
EDO  A 302 (-4.5A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.6A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
None
 0.56A 3f8wC-5ko5A:
44.1		 3f8wC-5ko5A:
62.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		9 / 12 SER A  35
HIS A  88
TYR A  90
TYR A 202
GLU A 203
VAL A 219
GLY A 220
MET A 221
VAL A 262
 EDO  A 302 (-3.6A)
EDO  A 302 (-4.5A)
None
CYT  A 301 (-4.6A)
CYT  A 301 (-2.9A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
None
 0.93A 3f8wC-5ko5A:
44.1		 3f8wC-5ko5A:
62.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		7 / 12 TYR A 202
GLU A 203
VAL A 219
GLY A 220
MET A 221
ASN A 245
VAL A 262
 CYT  A 301 (-4.6A)
CYT  A 301 (-2.9A)
None
CYT  A 301 (-3.3A)
CYT  A 301 (-4.1A)
CYT  A 301 (-3.2A)
None
 1.08A 3f8wC-5ko5A:
44.1		 3f8wC-5ko5A:
62.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 6 THR A 223
ASN A 117
GLY A  34
ILE A  31
 None
None
EDO  A 302 (-3.4A)
None
 0.98A 3w9tF-5ko5A:
undetectable		 3w9tF-5ko5A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 5 LYS A 135
ILE A 138
VAL A 218
LEU A 126
 None
 1.06A 3wzdA-5ko5A:
undetectable		 3wzdA-5ko5A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 7 ARG A  86
SER A 222
GLY A  38
GLY A  36
GLU A 267
 EDO  A 302 (-4.3A)
EDO  A 302 (-3.0A)
None
None
None
 1.35A 4koeA-5ko5A:
undetectable
4koeB-5ko5A:
undetectable
4koeD-5ko5A:
2.9		 4koeA-5ko5A:
21.96
4koeB-5ko5A:
21.96
4koeD-5ko5A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 7 TYR A 168
VAL A 237
ILE A  32
HIS A 137
 None
 1.07A 4xo7B-5ko5A:
undetectable		 4xo7B-5ko5A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 7 ARG A  86
GLY A  38
GLY A  36
GLU A 267
SER A 222
 EDO  A 302 (-4.3A)
None
None
None
EDO  A 302 (-3.0A)
 1.38A 4z53A-5ko5A:
undetectable
4z53B-5ko5A:
undetectable		 4z53A-5ko5A:
17.69
4z53B-5ko5A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC404_0
(PROTON-GATED ION
CHANNEL)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 4 ILE A 134
ILE A 115
ARG A  86
TYR A 194
 None
None
EDO  A 302 (-4.3A)
None
 1.47A 4zzbC-5ko5A:
undetectable		 4zzbC-5ko5A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 12 ILE A  31
LEU A  37
GLY A  76
LEU A 284
THR A 282
 None
 1.07A 5byjA-5ko5A:
undetectable		 5byjA-5ko5A:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 4 ILE A 280
ILE A 179
ARG A 283
LEU A 172
 None
 1.39A 5dzkh-5ko5A:
undetectable
5dzkn-5ko5A:
undetectable
5dzkv-5ko5A:
undetectable		 5dzkh-5ko5A:
24.32
5dzkn-5ko5A:
24.32
5dzkv-5ko5A:
1.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 4 ALA A 119
PRO A 225
LEU A  87
HIS A  88
 None
None
None
EDO  A 302 (-4.5A)
 1.19A 5eskA-5ko5A:
undetectable		 5eskA-5ko5A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 12 ILE A  19
PHE A  58
GLY A  68
LEU A  87
ILE A  32
 None
 1.08A 5m24A-5ko5A:
undetectable		 5m24A-5ko5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		5 / 12 ILE A 243
GLY A 192
TYR A 168
ALA A 239
ASP A 187
 None
 1.06A 5x66A-5ko5A:
undetectable
5x66B-5ko5A:
undetectable		 5x66A-5ko5A:
23.62
5x66B-5ko5A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE
(Schistosoma
mansoni) 		4 / 6 ARG A 103
ALA A  99
LEU A 100
ALA A  12
 None
 1.22A 6fosB-5ko5A:
undetectable		 6fosB-5ko5A:
12.67