SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ko8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QXY_A_SAMA6734_0 (N-LYSINE METHYLTRANSFERASE SETD6)	5ko8	NITROREDUCTASE (Haliscomenobacte r hydrossis)	5 / 12	ALA A 122 GLY A 199 HIS A 172 LEU A 195 PHE A 118	None None FMN A 301 ( 3.6A) None None	1.16A	3qxyA-5ko8A: undetectable	3qxyA-5ko8A: 18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RC0_B_SAMB480_0 (N-LYSINE METHYLTRANSFERASE SETD6)	5ko8	NITROREDUCTASE (Haliscomenobacte r hydrossis)	5 / 12	ALA A 122 GLY A 199 HIS A 172 LEU A 195 PHE A 118	None None FMN A 301 ( 3.6A) None None	1.13A	3rc0B-5ko8A: undetectable	3rc0B-5ko8A: 18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FIA_A_0U9A601_1 (CHOLESTEROL 24-HYDROXYLASE)	5ko8	NITROREDUCTASE (Haliscomenobacte r hydrossis)	5 / 12	PHE A 118 LEU A 195 VAL A 127 GLU A 88 ALA A 87	None	1.24A	4fiaA-5ko8A: undetectable	4fiaA-5ko8A: 20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FIA_A_198A602_1 (CHOLESTEROL 24-HYDROXYLASE)	5ko8	NITROREDUCTASE (Haliscomenobacte r hydrossis)	5 / 12	PHE A 118 LEU A 195 VAL A 127 GLU A 88 ALA A 87	None	1.24A	4fiaA-5ko8A: undetectable	4fiaA-5ko8A: 20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AYC_A_1YNA502_2 (PROTEIN CYP51)	5ko8	NITROREDUCTASE (Haliscomenobacte r hydrossis)	4 / 7	VAL A 151 PRO A 176 PHE A 129 LEU A 180	None	1.11A	6aycA-5ko8A: undetectable	6aycA-5ko8A: 15.89

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3QXY_A_SAMA6734_0","N-LYSINE METHYLTRANSFERASE SETD6","5ko8","NITROREDUCTASE","Haliscomenobacter hydrossis",5,"ALA A 122;GLY A 199;HIS A 172;LEU A 195;PHE A 118","None;None;FMN A 301 ( 3.6A);None;None","1.16A","3qxyA-5ko8A:undetectable","3qxyA-5ko8A:18.69"],["3RC0_B_SAMB480_0","N-LYSINE METHYLTRANSFERASE SETD6","5ko8","NITROREDUCTASE","Haliscomenobacter hydrossis",5,"ALA A 122;GLY A 199;HIS A 172;LEU A 195;PHE A 118","None;None;FMN A 301 ( 3.6A);None;None","1.13A","3rc0B-5ko8A:undetectable","3rc0B-5ko8A:18.69"],["4FIA_A_0U9A601_1","CHOLESTEROL 24-HYDROXYLASE","5ko8","NITROREDUCTASE","Haliscomenobacter hydrossis",5,"PHE A 118;LEU A 195;VAL A 127;GLU A  88;ALA A  87","None","1.24A","4fiaA-5ko8A:undetectable","4fiaA-5ko8A:20.17"],["4FIA_A_198A602_1","CHOLESTEROL 24-HYDROXYLASE","5ko8","NITROREDUCTASE","Haliscomenobacter hydrossis",5,"PHE A 118;LEU A 195;VAL A 127;GLU A  88;ALA A  87","None","1.24A","4fiaA-5ko8A:undetectable","4fiaA-5ko8A:20.17"],["6AYC_A_1YNA502_2","PROTEIN CYP51","5ko8","NITROREDUCTASE","Haliscomenobacter hydrossis",4,"VAL A 151;PRO A 176;PHE A 129;LEU A 180","None","1.11A","6aycA-5ko8A:undetectable","6aycA-5ko8A:15.89"]]