SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5koa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 5koa CELL DIVISION
PROTEIN ZAPD
(Escherichia
coli) 		4 / 6 TRP A  18
LEU A 168
LEU A 164
PRO A 163
 None
 1.23A 1hz4A-5koaA:
3.2		 1hz4A-5koaA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 5koa CELL DIVISION
PROTEIN ZAPD
(Escherichia
coli) 		4 / 8 HIS A  37
ARG A  45
VAL A 121
TRP A 142
 None
 1.34A 1u1jA-5koaA:
undetectable		 1u1jA-5koaA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 5koa CELL DIVISION
PROTEIN ZAPD
(Escherichia
coli) 		4 / 5 LEU A 112
ASP A 115
VAL A  47
ILE A 118
 None
 0.81A 2aoiB-5koaA:
undetectable		 2aoiB-5koaA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 5koa CELL DIVISION
PROTEIN ZAPD
(Escherichia
coli) 		4 / 8 LEU A 244
ASN A 204
LEU A 205
ARG A 202
 None
 0.96A 2xn3A-5koaA:
undetectable
2xn3B-5koaA:
undetectable		 2xn3A-5koaA:
20.87
2xn3B-5koaA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5koa CELL DIVISION
PROTEIN ZAPD
(Escherichia
coli) 		5 / 12 SER A 209
PHE A 242
ARG A 225
VAL A 236
SER A 186
 None
 1.50A 2xpvA-5koaA:
undetectable		 2xpvA-5koaA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 5koa CELL DIVISION
PROTEIN ZAPD
(Escherichia
coli) 		5 / 12 LEU A  74
LEU A  91
GLN A  94
MET A 170
VAL A 171
 None
 1.43A 2yloA-5koaA:
undetectable		 2yloA-5koaA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5koa CELL DIVISION
PROTEIN ZAPD
(Escherichia
coli) 		3 / 3 ALA A 223
ARG A 221
LYS A 219
 None
 1.07A 3kp5B-5koaA:
undetectable		 3kp5B-5koaA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5koa CELL DIVISION
PROTEIN ZAPD
(Escherichia
coli) 		5 / 12 ILE A 158
TRP A 157
PHE A  44
PHE A  43
LEU A 139
 None
 1.41A 6a93A-5koaA:
3.2		 6a93A-5koaA:
22.19