SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kob'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 5kob PEPTIDE DEFORMYLASE
(Paraburkholderia
xenovorans) 		5 / 12 THR A 164
GLY A  98
GLY A 104
VAL A 138
ARG A 137
 None
FMT  A 202 ( 4.3A)
None
FMT  A 202 ( 3.9A)
None
 1.16A 2b25B-5kobA:
undetectable		 2b25B-5kobA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_B_HAEB271_1
(COLLAGENASE 3)		 5kob PEPTIDE DEFORMYLASE
(Paraburkholderia
xenovorans) 		3 / 3 HIS A 141
GLU A 142
HIS A 145
 FE2  A 201 (-3.3A)
FE2  A 201 ( 4.2A)
FE2  A 201 (-3.4A)
 0.22A 3kecB-5kobA:
undetectable		 3kecB-5kobA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 5kob PEPTIDE DEFORMYLASE
(Paraburkholderia
xenovorans) 		5 / 12 PRO A 152
GLY A 162
PHE A 161
GLY A  98
TYR A 151
 None
None
None
FMT  A 202 ( 4.3A)
None
 1.20A 4lxzC-5kobA:
undetectable		 4lxzC-5kobA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 5kob PEPTIDE DEFORMYLASE
(Paraburkholderia
xenovorans) 		4 / 7 ILE A 127
TYR A 117
PHE A  61
ARG A 129
 None
 1.33A 4o7gA-5kobA:
undetectable
4o7gB-5kobA:
undetectable		 4o7gA-5kobA:
19.41
4o7gB-5kobA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 5kob PEPTIDE DEFORMYLASE
(Paraburkholderia
xenovorans) 		5 / 11 ARG A  12
LEU A  13
ARG A  15
LEU A   6
LEU A 150
 None
 1.46A 4or0A-5kobA:
undetectable		 4or0A-5kobA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 5kob PEPTIDE DEFORMYLASE
(Paraburkholderia
xenovorans) 		5 / 7 GLU A 142
ARG A  68
TYR A  69
GLY A  44
GLY A  46
 FE2  A 201 ( 4.2A)
None
FMT  A 202 ( 4.1A)
FMT  A 203 (-3.2A)
FMT  A 203 ( 4.9A)
 1.37A 4rdxA-5kobA:
undetectable		 4rdxA-5kobA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 5kob PEPTIDE DEFORMYLASE
(Paraburkholderia
xenovorans) 		4 / 8 HIS A 145
GLU A 142
ASP A 144
ARG A 154
 FE2  A 201 (-3.4A)
FE2  A 201 ( 4.2A)
FMT  A 204 (-3.7A)
None
 1.16A 4uhxA-5kobA:
undetectable		 4uhxA-5kobA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 5kob PEPTIDE DEFORMYLASE
(Paraburkholderia
xenovorans) 		4 / 8 HIS A 145
GLU A 142
ASP A 144
ARG A 154
 FE2  A 201 (-3.4A)
FE2  A 201 ( 4.2A)
FMT  A 204 (-3.7A)
None
 1.16A 4uhxA-5kobA:
undetectable		 4uhxA-5kobA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 5kob PEPTIDE DEFORMYLASE
(Paraburkholderia
xenovorans) 		5 / 12 PRO A 152
GLY A 162
PHE A 161
PHE A 163
TYR A 151
 None
 1.46A 5eeiA-5kobA:
undetectable		 5eeiA-5kobA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5kob PEPTIDE DEFORMYLASE
(Paraburkholderia
xenovorans) 		3 / 3 GLU A 142
HIS A 141
ARG A 137
 FE2  A 201 ( 4.2A)
FE2  A 201 (-3.3A)
None
 0.95A 5uunA-5kobA:
undetectable		 5uunA-5kobA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5kob PEPTIDE DEFORMYLASE
(Paraburkholderia
xenovorans) 		3 / 3 HIS A 145
HIS A 141
ARG A 111
 FE2  A 201 (-3.4A)
FE2  A 201 (-3.3A)
None
 1.13A 6b58A-5kobA:
undetectable		 6b58A-5kobA:
16.17