SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5kod'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQB_A_RTLA185_0
(RETINOL-BINDING
PROTEIN)		 5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5
(Arabidopsis
thaliana) 		5 / 10 LEU A  25
ALA A 339
VAL A 140
MET A 366
LEU A 349
 None
IAC  A 702 (-4.5A)
None
None
None
 1.41A 1aqbA-5kodA:
undetectable		 1aqbA-5kodA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5
(Arabidopsis
thaliana) 		5 / 10 LEU A 474
ALA A 470
LEU A 481
GLU A 517
LEU A 499
 None
 1.15A 1ie4A-5kodA:
undetectable
1ie4C-5kodA:
undetectable		 1ie4A-5kodA:
11.44
1ie4C-5kodA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5
(Arabidopsis
thaliana) 		5 / 10 THR A 314
VAL A 358
VAL A 311
ILE A 312
VAL A 313
 AMP  A 701 (-3.5A)
None
None
AMP  A 701 (-3.7A)
None
 1.49A 2qboA-5kodA:
undetectable		 2qboA-5kodA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5
(Arabidopsis
thaliana) 		4 / 9 ALA A 283
VAL A 286
CYH A 290
LYS A 291
 None
 0.79A 2vufB-5kodA:
undetectable		 2vufB-5kodA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5
(Arabidopsis
thaliana) 		4 / 7 SER A 207
GLN A 533
ILE A 159
SER A 537
 None
 1.29A 2xz5A-5kodA:
undetectable
2xz5B-5kodA:
undetectable		 2xz5A-5kodA:
16.67
2xz5B-5kodA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5
(Arabidopsis
thaliana) 		5 / 12 LEU A 412
GLY A 346
LEU A 136
SER A 135
ALA A 367
 None
 1.12A 3i5uB-5kodA:
undetectable		 3i5uB-5kodA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQ7_B_DX2B271_1
(PTERIDINE REDUCTASE
1)		 5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5
(Arabidopsis
thaliana) 		4 / 8 PHE A 345
ASP A 427
TYR A 338
LEU A 420
 None
AMP  A 701 (-2.8A)
None
None
 0.95A 3jq7B-5kodA:
undetectable		 3jq7B-5kodA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5
(Arabidopsis
thaliana) 		4 / 4 GLY A 153
TYR A 155
GLY A 229
ASP A 310
 None
 1.18A 3kl3A-5kodA:
undetectable		 3kl3A-5kodA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5
(Arabidopsis
thaliana) 		4 / 8 ASN A 465
ASP A 459
GLU A  80
GLU A  83
 None
 1.04A 3sg9B-5kodA:
undetectable		 3sg9B-5kodA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5
(Arabidopsis
thaliana) 		5 / 11 GLY A 495
GLN A 319
THR A 323
PHE A 232
GLY A 235
 None
None
None
IAC  A 702 (-4.6A)
None
 1.27A 3wg7A-5kodA:
2.3
3wg7B-5kodA:
undetectable
3wg7T-5kodA:
undetectable		 3wg7A-5kodA:
20.72
3wg7B-5kodA:
17.51
3wg7T-5kodA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5
(Arabidopsis
thaliana) 		4 / 8 TYR A 594
TRP A 501
LEU A 503
LEU A 474
 None
 1.04A 4jtrA-5kodA:
undetectable		 4jtrA-5kodA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5
(Arabidopsis
thaliana) 		3 / 3 LYS A 354
PRO A 355
SER A 356
 None
 0.28A 4k50I-5kodA:
undetectable		 4k50I-5kodA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5
(Arabidopsis
thaliana) 		4 / 6 ILE A 263
SER A 213
PHE A 242
LEU A 250
 None
 0.98A 4m51A-5kodA:
undetectable		 4m51A-5kodA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_A_ACTA404_0
(PROTON-GATED ION
CHANNEL)		 5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5
(Arabidopsis
thaliana) 		4 / 4 LEU A 216
ILE A 263
ARG A 252
TYR A 212
 None
 1.06A 4zzbA-5kodA:
undetectable		 4zzbA-5kodA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA406_0
(PROTON-GATED ION
CHANNEL)		 5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5
(Arabidopsis
thaliana) 		4 / 4 LEU A 216
ILE A 263
ARG A 252
TYR A 212
 None
 1.08A 4zzcA-5kodA:
undetectable		 4zzcA-5kodA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB406_0
(PROTON-GATED ION
CHANNEL)		 5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5
(Arabidopsis
thaliana) 		4 / 4 LEU A 216
ILE A 263
ARG A 252
TYR A 212
 None
 1.13A 4zzcB-5kodA:
undetectable		 4zzcB-5kodA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5
(Arabidopsis
thaliana) 		5 / 11 VAL A 311
VAL A 309
ILE A 493
ILE A 240
LEU A 324
 None
 1.12A 5e4dB-5kodA:
undetectable		 5e4dB-5kodA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5
(Arabidopsis
thaliana) 		4 / 7 ILE A 541
GLY A 542
PHE A 500
ASP A 489
 None
 1.04A 5hieA-5kodA:
undetectable		 5hieA-5kodA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5
(Arabidopsis
thaliana) 		4 / 6 SER A 365
GLY A 346
MET A 366
ILE A  28
 None
 1.08A 5j4nA-5kodA:
undetectable		 5j4nA-5kodA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5
(Arabidopsis
thaliana) 		4 / 8 LEU A 250
LEU A 259
ILE A 202
THR A 201
 None
 1.03A 5ljbA-5kodA:
undetectable		 5ljbA-5kodA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5
(Arabidopsis
thaliana) 		5 / 11 GLY A 495
GLN A 319
THR A 323
PHE A 232
GLY A 235
 None
None
None
IAC  A 702 (-4.6A)
None
 1.33A 5x19A-5kodA:
0.1
5x19B-5kodA:
undetectable
5x19T-5kodA:
undetectable		 5x19A-5kodA:
20.72
5x19B-5kodA:
17.51
5x19T-5kodA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5
(Arabidopsis
thaliana) 		5 / 11 GLY A 495
GLN A 319
THR A 323
PHE A 232
GLY A 235
 None
None
None
IAC  A 702 (-4.6A)
None
 1.27A 5xdqA-5kodA:
0.5
5xdqB-5kodA:
undetectable
5xdqT-5kodA:
undetectable		 5xdqA-5kodA:
20.72
5xdqB-5kodA:
17.51
5xdqT-5kodA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5
(Arabidopsis
thaliana) 		5 / 11 GLY A 495
GLN A 319
THR A 323
PHE A 232
GLY A 235
 None
None
None
IAC  A 702 (-4.6A)
None
 1.29A 5zcoA-5kodA:
1.3
5zcoB-5kodA:
undetectable
5zcoT-5kodA:
undetectable		 5zcoA-5kodA:
20.72
5zcoB-5kodA:
17.51
5zcoT-5kodA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5
(Arabidopsis
thaliana) 		5 / 11 GLY A 495
GLN A 319
THR A 323
PHE A 232
GLY A 235
 None
None
None
IAC  A 702 (-4.6A)
None
 1.32A 5zcpA-5kodA:
2.2
5zcpB-5kodA:
undetectable
5zcpT-5kodA:
undetectable		 5zcpA-5kodA:
20.72
5zcpB-5kodA:
17.51
5zcpT-5kodA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5
(Arabidopsis
thaliana) 		4 / 8 TRP A 295
LEU A 219
GLU A 289
TRP A 303
 None
 1.01A 6c71B-5kodA:
undetectable		 6c71B-5kodA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5
(Arabidopsis
thaliana) 		5 / 11 GLY A 495
GLN A 319
THR A 323
PHE A 232
GLY A 235
 None
None
None
IAC  A 702 (-4.6A)
None
 1.32A 6nknA-5kodA:
0.1
6nknB-5kodA:
undetectable
6nknT-5kodA:
undetectable		 6nknA-5kodA:
20.72
6nknB-5kodA:
17.51
6nknT-5kodA:
9.60